Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Value Type Rank Network Comparison Type description Interaction Map Filtered green red network_comparison
Results: HTML CSV LaTeX Showing element 1 to 50 of 7460 in total
Value Type  : Ranked
Interaction Map  : High confidence
Rank
Network Comparison Type
description
Filtered
green
red
network_comparison
1 Divided adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61] 0 15915 4294 3.70633
putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172] 1 24 10 2.4
Subtracted homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774] 322 215 107
mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3] 0 21883 8906 12977
2 Divided mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 1 28 15 1.86667
mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849] 0 14977 5865 2.55362
Subtracted adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61] 15915 4294 11621
hbs1-like. [refseq;acc:nm_006620] 1 322 215 107
3 Divided cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] 28 15 1.86667
nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8] 0 11083.9 4475.84 2.47638
Subtracted cab2. [refseq;acc:nm_033419] 10950 21866 10916
rad50-interacting protein 1. [refseq;acc:nm_021930] 1 232 337 105
4 Divided cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418] 28 15 1.86667
mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3] 0 21883 8906 2.45711
Subtracted nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7] 21888 11525 10363
rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6] 1 232 337 105
5 Divided cytohesin 4. [swissprot;acc:q9uia0] 28 15 1.86667
ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855] 0 11965.7 5510.5 2.17144
Subtracted transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87] 21888 11525 10363
xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266] 1 309 212 97
6 Divided cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739] 28 15 1.86667
ubiquitin protein ligase. [refseq;acc:nm_130466] 0 15339.2 7523 2.03897
Subtracted mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849] 14977 5865 9112
protein x 0004. [refseq;acc:nm_016301] 1 309 212 97
7 Divided cab2. [refseq;acc:nm_033419] 0 10950 21866 1.99689
homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774] 1 322 215 1.49767
Subtracted homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017] 0 13216 22286 9070
protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8] 1 212.554 288.754 76.2
8 Divided hbs1-like. [refseq;acc:nm_006620] 322 215 1.49767
nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7] 0 21888 11525 1.89918
Subtracted homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630] 13216 22286 9070
junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2] 1 362 288 74
9 Divided transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87] 0 21888 11525 1.89918
xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266] 1 309 212 1.45755
Subtracted homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056] 0 13216 22286 9070
junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39] 1 362 288 74
10 Divided fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757] 0 14178.1 7509.39 1.88805
protein x 0004. [refseq;acc:nm_016301] 1 309 212 1.45755
Subtracted pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129] 0 12479 20989 8510
sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906] 1 362 288 74
11 Divided potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110] 0 6248 11627 1.86092
rad50-interacting protein 1. [refseq;acc:nm_021930] 1 232 337 1.45259
Subtracted cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946] 0 20670.6 12170.7 8499.9
db83 protein. [swissprot;acc:p57088] 1 362 288 74
12 Divided folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932] 0 5208.84 9429.18 1.81023
rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6] 1 232 337 1.45259
Subtracted guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262] 336.233 266.856 69.377
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521] 0 11267 19403 8136
13 Divided heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107] 9264.5 5210.5 1.77804
protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8] 1 212.554 288.754 1.3585

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/