MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Value Type	green	Gene	Rank	Network Comparison Type	Interaction Map	Filtered	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

description	Value Type	green	Rank	red	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Measured	2765.82	60	4489.19	1.6231
	Ranked	245.247	18	185.678	1.32082
	Squared	6768.05	245	8875.01	1.31131
	Rooted	47.2654	64	63.8686	1.35128
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	Measured	8630.06	509	7551.8	1.14278
	Ranked	181.041	1038	186.741	1.03148
	Squared	39351.7	295	30807.7	1.27733
	Rooted	79.1513	805	74.3557	1.0645
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	Measured	8636.87	508	7556.75	1.14293
	Ranked	180.943	1032	186.664	1.03162
	Squared	39383.9	294	30826.5	1.2776
	Rooted	79.1931	804	74.3877	1.0646
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	Measured	8532.02	514	7477	1.1411
	Ranked	182.308	1048	187.96	1.031
	Squared	38866.5	311	30566.4	1.27154
	Rooted	78.5795	822	73.8577	1.06393
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	Measured	8543.66	513	7485.08	1.14143
	Ranked	182.137	1043	187.834	1.03128
	Squared	38919.9	308	30596.2	1.27205
	Rooted	78.6514	811	73.9102	1.06415
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	Measured	0.00001	3126	0.00001	1
	Ranked
	Squared
	Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	Measured	6303.92	1136	5790.65	1.08864
	Ranked	213.703	1963	211.633	1.00978
	Squared	27879.3	588	23526.4	1.18502
	Rooted	65.2789	1907	63.4353	1.02906
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	Measured	0.00001	2922	0.00001	1
	Ranked
	Squared
	Rooted
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]	Measured	6262.07	1411	5812.02	1.07743
	Ranked	221.425	2439	220.681	1.00337
	Squared	32561.8	1143	28551.5	1.14046
	Rooted	63.0838	1943	61.3337	1.02853
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	Measured	0.00001	3088	0.00001	1
	Ranked
	Squared
	Rooted
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	Measured	6265.44	1415	5815.33	1.0774
	Ranked	221.51	2396	220.683	1.00375
	Squared	32641.7	1135	28600.9	1.14128
	Rooted	63.0743	1961	61.3419	1.02824
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	Measured	6788.96	1600	6336.22	1.07145
	Ranked	202.529	2366	203.353	1.00407
	Squared	29768.2	921	25739.7	1.15651
	Rooted	68.7832	2036	66.966	1.02714
15 kda selenoprotein precursor. [swissprot;acc:o60613]	Measured	6933.36	1043	6344.41	1.09283
	Ranked	212.432	1948	214.522	1.00984

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.