MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Network Comparison Type	Rank	description	Value Type	Interaction Map	Filtered	green	network_comparison	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 25824 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	green	network_comparison	red
1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Ranked	24	2.4	10
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Measured	2394.5	5.31521	450.5
		Squared	1357.07	28.2513	48.0356
		Rooted	48.9336	2.30547	21.225
2	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Ranked	28	1.86667	15
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Measured	2394.5	5.31521	450.5
		Squared	1357.07	28.2513	48.0356
		Rooted	48.9336	2.30547	21.225
3	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Ranked	28	1.86667	15
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Measured	698.5	3.71868	2597.5
		Squared	115.48	13.8285	1596.92
		Rooted	26.4292	1.92839	50.9657
4	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Ranked	28	1.86667	15
	hbs1-like. [refseq;acc:nm_006620]	Measured	698.5	3.71868	2597.5
		Squared	115.48	13.8285	1596.92
		Rooted	26.4292	1.92839	50.9657
5	cytohesin 4. [swissprot;acc:q9uia0]	Ranked	28	1.86667	15
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Measured	339.5	3.39764	1153.5
		Squared	27.2805	11.544	314.926
		Rooted	18.4255	1.84327	33.9632
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Ranked	28	1.86667	15
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Measured	339.5	3.39764	1153.5
		Squared	27.2805	11.544	314.926
		Rooted	18.4255	1.84327	33.9632
7	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Ranked	322	1.49767	215
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Measured	339.5	3.39764	1153.5
		Squared	27.2805	11.544	314.926
		Rooted	18.4255	1.84327	33.9632
8	db83 protein. [swissprot;acc:p57088]	Measured	339.5	3.39764	1153.5
		Squared	27.2805	11.544	314.926
		Rooted	18.4255	1.84327	33.9632
	hbs1-like. [refseq;acc:nm_006620]	Ranked	322	1.49767	215
9	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Measured	1281.5	3.21581	398.5
		Squared	388.696	10.3414	37.5863
		Rooted	35.798	1.79326	19.9625
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Ranked	309	1.45755	212
10	protein x 0004. [refseq;acc:nm_016301]
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Measured	1281.5	3.21581	398.5
		Squared	388.696	10.3414	37.5863
		Rooted	35.798	1.79326	19.9625
11	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Measured	1281.5	3.21581	398.5
		Squared	388.696	10.3414	37.5863
		Rooted	35.798	1.79326	19.9625
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Ranked	232	1.45259	337
12	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Measured	1281.5	3.21581	398.5
		Squared	388.696	10.3414	37.5863
		Rooted	35.798	1.79326	19.9625
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Ranked	232	1.45259	337
13	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Measured	1281.5	3.21581	398.5
		Squared	388.696	10.3414	37.5863

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.