MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Value Type	Network Comparison Type	Gene	Rank	red	description	green	Interaction Map	network_comparison	Filtered

Results: HTML CSV LaTeX

Showing element 1 to 50 of 29840 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	red	description	green	network_comparison	Filtered
1	364	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0.00001	36400000	0
	450.5	rad50-interacting protein 1. [refseq;acc:nm_021930]	2394.5	5.31521	1
2	0.00001	cab2. [refseq;acc:nm_033419]	174	17400000	0
	450.5	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	2394.5	5.31521	1
3	0.00001	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	109	10900000	0
	2597.5	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	698.5	3.71868	1
4	0.00001	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	89	8900000	0
	2597.5	hbs1-like. [refseq;acc:nm_006620]	698.5	3.71868	1
5	0.00001	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	89	8900000	0
	1153.5	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	339.5	3.39764	1
6	0.00001	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	89	8900000	0
	1153.5	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	339.5	3.39764	1
7	0.00001	sedlin. [swissprot;acc:o14582]	43	4300000	0
	1153.5	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	339.5	3.39764	1
8	0.00001	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	43	4300000	0
	1153.5	db83 protein. [swissprot;acc:p57088]	339.5	3.39764	1
9	85	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	6410	75.4118	0
	398.5	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	1281.5	3.21581	1
10	85	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	6410	75.4118	0
	398.5	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	1281.5	3.21581	1
11	199.549	serpin b12. [swissprot;acc:q96p63]	5.56738	35.8425	0
	398.5	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	1281.5	3.21581	1
12	199.249	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	5.71669	34.8539	0
	398.5	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	1281.5	3.21581	1
13		cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]
	1363	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	47	29	0
14	130.512	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	6.50325	20.0687
	398.5	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	1281.5	3.21581	1
15	10	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	156	15.6	0
	2671	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	871	3.06659	1
16	1	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	15	15	0
	2671	protein x 0004. [refseq;acc:nm_016301]	871	3.06659	1
17	460	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	1365	2.96739
	859	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	58	14.8103	0
18	305.45	60s ribosomal protein l37a. [swissprot;acc:p12751]	26.1599	11.6763
	677.5	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	1865.5	2.75351	1
19	305.45	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	26.1599	11.6763	0
	677.5	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	1865.5	2.75351	1
20	82	ero1-like. [refseq;acc:nm_014584]	0.00001	8200000	0
	677.5	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	1865.5	2.75351	1
21	118.878	syntaxin 10 (syn10). [swissprot;acc:o60499]	17.6611	6.73106	0
	677.5	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	1865.5	2.75351	1
22	60	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	0.00001	6000000	0
	677.5	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	1865.5	2.75351	1
23	0.00001	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	59	5900000	0
	699.76	gbp protein isoform a. [refseq;acc:nm_017870]	1894.39	2.7072	1
24	30	ptd016 protein. [refseq;acc:nm_016125]	158	5.26667	0
	950.561	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	2108.52	2.21818	1
25	148	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	773	5.22297	0
	1833.01	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	892.67	2.0534	1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.