Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Gene Rank Value Type green description Network Comparison Type Interaction Map network_comparison Filtered red
Results: HTML CSV LaTeX Showing element 3180 to 3229 of 16578 in total
Value Type  : Ranked
Filtered  : 1
Rank
green
description
Network Comparison Type
Interaction Map
network_comparison
red
795 234.511 serpin b11. [swissprot;acc:q96p15] Divided High confidence 1.04578 224.244
796 197.308 grancalcin. [swissprot;acc:p28676] Low confidence 1.02644 202.524
197.536 rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640] Subtracted 5.219 202.755
221.785 beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115] High confidence 9.399 212.386
234.511 placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237] Divided 1.04578 224.244
797 197.308 calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632] Subtracted Low confidence 5.217 202.525
206.184 asc-1 complex subunit p100. [refseq;acc:nm_032204] Divided 1.02644 211.636
221.785 syntaxin 16 (syn16). [swissprot;acc:o14662] Subtracted High confidence 9.399 212.386
234.511 cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452] Divided 1.04578 224.244
798 197.308 grancalcin. [swissprot;acc:p28676] Subtracted Low confidence 5.216 202.524
sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626] Divided 1.02644
221.785 27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653] Subtracted High confidence 9.399 212.386
234.511 leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740] Divided 1.04578 224.244
799 196.11 amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433] Low confidence 1.02643 201.294
201.027 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643] Subtracted 5.216 206.243
212.404 sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900] Divided High confidence 1.04501 221.965
221.785 syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623] Subtracted 9.399 212.386
800 197.536 rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640] Divided Low confidence 1.02642 202.755
201.028 dopachrome tautomerase precursor (ec 5.3.3.12) (dt) (dct) (dopachrome delta-isomerase) (tyrosinase-related protein 2) (trp-2) (trp2). [swissprot;acc:p40126] Subtracted 5.216 206.244
212.404 nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307] Divided High confidence 1.04501 221.965
221.785 alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920] Subtracted 9.399 212.386
801 197.308 sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626] Low confidence 5.216 202.524
197.311 programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340] Divided 1.02641 202.522
214.894 beta-catenin (pro2286). [swissprot;acc:p35222] High confidence 1.04445 224.445
221.785 adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9] Subtracted 9.399 212.386
802 196.126 xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7] Low confidence 5.212 201.338
198.117 dc12 protein. [refseq;acc:nm_020187] Divided 1.02639 203.345
221.785 synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721] Subtracted High confidence 9.399 212.386
testis-specific protein tex28. [swissprot;acc:o15482] Divided 1.04425
803 194.441 dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kda subunit precursor (ec 2.4.1.119) (ribophorin i) (rpn-i). [swissprot;acc:p04843] Low confidence 1.02639 199.573
199.711 olf-1/ebf associated zinc finger protein; smad- and olf-interacting zinc finger protein. [refseq;acc:nm_015069] Subtracted 5.211 204.922
221.785 similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61] Divided High confidence 1.04425 212.386
syntaxin 1b. [swissprot;acc:q15531] Subtracted 9.399
804 197.311 programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340] Low confidence 5.211 202.522
199.267 elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897] Divided 1.02636 204.519
221.785 a kindred of iglon. [refseq;acc:nm_173808] High confidence 1.04425 212.386
melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084] Subtracted 9.399
805 193.399 synaptojanin 1 (ec 3.1.3.36) (synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1). [swissprot;acc:o43426] Divided Low confidence 1.02635 198.496
199.706 early hematopoietic zinc finger. [refseq;acc:nm_015461] Subtracted 5.208 204.914
221.785 ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1] Divided High confidence 1.04425 212.386
dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593] Subtracted 9.399
806 197.173 vacuolar atp synthase subunit c (ec 3.6.3.14) (v-atpase c subunit) (vacuolar proton pump c subunit). [swissprot;acc:p21283] Divided Low confidence 1.02635 202.369
202.355 mosaic protein lgn. [swissprot;acc:p81274] Subtracted 5.205 207.56
221.785 inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370] Divided High confidence 1.04425 212.386
276.773 maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708] Subtracted 9.326 267.447
807 195.631 myofibrillogenesis regulator 1; trans-activated by hepatitis c virus core protein 2; likely ortholog of mouse brain protein 17. [refseq;acc:nm_022572] Divided Low confidence 1.02633 200.782
198.706 nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208] Subtracted 5.201 203.907
221.785 palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897] Divided High confidence 1.04425 212.386
227.796 trifunctional purine biosynthetic protein adenosine-3 [includes: phosphoribosylamine--glycine ligase (ec 6.3.4.13) (gars) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); phosphoribosylformylglycinamidine cyclo-ligase (ec 6.3.3.1) (airs) (phosphoribosyl-aminoimidazole synthetase) (air synthase); phosphoribosylglycinamide formyltransferase (ec 2.1.2.2) (gart) (gar transformylase) (5'-phosphoribosylglycinamide transformylase)]. [swissprot;acc:p22102] Subtracted 9.275 218.521
808 196.014 vigilin (high density lipoprotein-binding protein) (hdl-binding protein). [swissprot;acc:q00341] Divided Low confidence 1.0263 201.169

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/