MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1450 to 1499 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	green	red	network_comparison
1450	alpha crystallin c chain (small stress protein-like protein hsp22) (e2ig1) (protein kinase h11). [swissprot;acc:q9ujy1]	226.194	221.804	1.01979
1451	my016 protein. [sptrembl;acc:q9h3k6]	229.2	224.755	1.01978
1452	cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551]	163.554	160.381
1453	reticulon 4 (neurite outgrowth inhibitor) (nogo protein) (foocen) (neuroendocrine-specific protein) (nsp) (neuroendocrine specific protein c homolog) (rtn-x) (reticulon 5) (my043 protein). [swissprot;acc:q9nqc3]	211.13	207.038	1.01976
1454	sin3 associated polypeptide p18 (2hor0202). [swissprot;acc:o00422]	211.089	207.024	1.01964
1455	eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9]	211.085		1.01962
1456	eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]	211.086
1457	eh-domain containing protein 2. [swissprot;acc:q9nzn4]
1458	eh-domain containing protein 3. [swissprot;acc:q9nzn3]
1459	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]	188.637	192.336	1.01961
1460	thyroid receptor interacting protein 12 (trip12). [swissprot;acc:q14669]	209.851	205.817	1.0196
1461	reticulon 1 (neuroendocrine-specific protein). [swissprot;acc:q16799]	211.077	207.019
1462	dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor (ec 2.3.1.61) (e2) (e2k). [swissprot;acc:p36957]	209.851	205.817
1463	pnas-18. [sptrembl;acc:q9bzu3]	164.211	161.056	1.01959
1464	poly (adp-ribose) glycohydrolase. [refseq;acc:nm_003631]	213.18	217.351	1.01957
1465	mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2]
1466	reticulon protein 2 (neuroendocrine-specific protein-like 1) (nsp-like protein 1) (nspli). [swissprot;acc:o75298]	211.073	207.022
1467	maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]	232.983	228.513	1.01956
1468	dr1-associated protein 1; negative cofactor 2 alpha; dr1-associated corepressor. [refseq;acc:nm_006442]	207.937	212.001	1.01954
1469	reticulon protein 3 (neuroendocrine-specific protein-like 2) (nsp-like protein ii) (nsplii). [swissprot;acc:o95197]	211.05	207.013	1.0195
1470	glutaminyl-trna synthetase (ec 6.1.1.18) (glutamine--trna ligase) (glnrs). [swissprot;acc:p47897]	217.199	221.412	1.0194
1471	spermidine synthase (ec 2.5.1.16) (putrescine aminopropyltransferase) (spdsy). [swissprot;acc:p19623]
1472	glycyl-trna synthetase (ec 6.1.1.14) (glycine--trna ligase) (glyrs). [swissprot;acc:p41250]
1473	glutamyl trna synthetase. [sptrembl;acc:o14563]
1474	importin beta-3 subunit (karyopherin beta-3 subunit) (ran-binding protein 5). [swissprot;acc:o00410]	214.427	218.582	1.01938
1475	kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [swissprot;acc:q16719]	178.438	181.882	1.0193
1476	ran-gtp binding protein (fragment). [sptrembl;acc:o60518]	214.457	218.591	1.01928
1477	transformer-2 protein homolog (tra-2 alpha). [swissprot;acc:q13595]	211.267	215.328	1.01922
1478	arginine/serine-rich splicing factor 10 (transformer-2-beta) (htra2- beta) (transformer 2 protein homolog) (silica-induced protein 41) (ra301). [swissprot;acc:q15815]	211.066	215.122
1479	maguk p55 subfamily member 6 (veli-associated maguk 1) (vam-1). [swissprot;acc:q9nzw5]	232.855	228.469	1.0192
1480	cleavage and polyadenylation specific factor 6, 68 kd subunit; pre-mrna cleavage factor im (68kd); cleavage and polyadenylation specific factor 6, 68kd subunit; pre-mrna cleavage factor i, 68kd subunit. [refseq;acc:nm_007007]	214.55	218.664	1.01918
1481	cell division cycle protein 23; anaphase-promoting complex subunit 8. [refseq;acc:nm_004661]	204.516	208.432	1.01915
1482	limbic system-associated membrane protein precursor (lsamp). [swissprot;acc:q13449]	220.15	224.354	1.0191
1483	pyruvate dehydrogenase e1 component beta subunit, mitochondrial precursor (ec 1.2.4.1) (pdhe1-b). [swissprot;acc:p11177]	202.726	198.927
1484	2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]
1485	j kappa-recombination signal binding protein (rbp-j kappa). [swissprot;acc:q06330]	203.989	207.877	1.01906
1486	human immunodeficiency virus type i enhancer binding protein 3. [refseq;acc:nm_024503]
1487	zinc finger protein 40 (human immunodeficiency virus type i enhancer- binding protein 1) (hiv-ep1) (major histocompatibility complex binding protein 1) (mbp-1) (positive regulatory domain ii binding factor 1) (prdii-bf1). [swissprot;acc:p15822]
1488	human immunodeficiency virus type i enhancer-binding protein 2 (hiv-ep2). [swissprot;acc:p31629]
1489	mitogen-activated protein kinase kinase kinase 7 (ec 2.7.1.-) (transforming growth factor-beta-activated kinase 1) (tgf-beta- activated kinase 1). [swissprot;acc:o43318]	209.264	213.251	1.01905
1490	protein cgi-147. [swissprot;acc:q9y3e5]	226.186	221.961	1.01903
1491	glucose-6-phosphate isomerase (ec 5.3.1.9) (gpi) (phosphoglucose isomerase) (pgi) (phosphohexose isomerase) (phi) (neuroleukin) (nlk) (sperm antigen-36) (sa-36). [swissprot;acc:p06744]	221.839	217.704	1.01899
1492	opioid binding protein/cell adhesion molecule precursor (obcam) (opioid-binding cell adhesion molecule) (opcml). [swissprot;acc:q14982]	220.017	224.159	1.01883
1493	pyruvate dehydrogenase e1 component alpha subunit, testis-specific form, mitochondrial precursor (ec 1.2.4.1) (pdhe1-a type ii). [swissprot;acc:p29803]	207.988	204.146	1.01882
1494	pyruvate dehydrogenase e1 component alpha subunit, somatic form, mitochondrial precursor (ec 1.2.4.1) (pdhe1-a type i). [swissprot;acc:p08559]	207.967	204.133	1.01878
1495	casein kinase i alpha s-like. [refseq;acc:nm_145203]	225.237	229.459	1.01874
1496	casein kinase i, alpha isoform (ec 2.7.1.-) (cki-alpha) (ck1). [swissprot;acc:p48729]
1497	exportin 1; exportin-1 (required for chromosome region maintenance); exportin 1 (crm1, yeast, homolog); crm1, yeast, homolog. [refseq;acc:nm_003400]	220.363	224.476	1.01866
1498	neurotrimin precursor (hnt). [swissprot;acc:q9p121]	219.924	224.022	1.01863
1499	transcription factor smif; decapping enzyme hdcp1a. [refseq;acc:nm_018403]	220.411	224.509	1.01859

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.