MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Gene	green	Filtered	Rank	Interaction Map	network_comparison	Value Type	description	red	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 551 to 600 of 77072 in total

green  : 0
Filtered  : 1
Interaction Map  : High confidence
network_comparison  : 0
red  : 0
Network Comparison Type  : Subtracted

Rank	Value Type	description
2869	Measured	phosphoribosyl pyrophosphate synthetase-associated protein 1 (prpp synthetase-associated protein 1) (39 kda phosphoribosypyrophosphate synthetase-associated protein) (pap39). [swissprot;acc:q14558]
	Ranked
	Squared
	Rooted
2870	Measured	adaptor protein with pleckstrin homology and src homology 2 domains. [refseq;acc:nm_020979]
	Ranked
	Squared
	Rooted
2871	Measured	vps28 protein homolog. [swissprot;acc:q9uk41]
	Ranked
	Squared
	Rooted
2872	Measured	transcriptional repressor nac1. [refseq;acc:nm_052876]
	Ranked
	Squared
	Rooted
2873	Measured	integrin beta-2 precursor (cell surface adhesion glycoproteins lfa- 1/cr3/p150,95 beta-subunit) (cd18) (complement receptor c3 beta- subunit). [swissprot;acc:p05107]
	Ranked
	Squared
	Rooted
2874	Measured	protein c21orf2 (c21orf-humf09g8.5) (yf5/a2). [swissprot;acc:o43822]
	Ranked
	Squared
	Rooted
2875	Measured	alpha crystallin a chain. [swissprot;acc:p02489]
	Ranked
	Squared
	Rooted
2876	Measured	high-affinity cgmp-specific 3',5'-cyclic phosphodiesterase 9a (ec 3.1.4.17). [swissprot;acc:o76083]
	Ranked
	Squared
	Rooted
2877	Measured	runt-related transcription factor 1 (core-binding factor, alpha 2 subunit) (cbf-alpha 2) (acute myeloid leukemia 1 protein) (oncogene aml-1) (polyomavirus enhancer binding protein 2 alpha b subunit) (pebp2-alpha b) (pea2-alpha b) (sl3-3 enhancer factor 1 alpha b subunit) (sl3/akv core-binding factor alpha b subunit). [swissprot;acc:q01196]
	Ranked
	Squared
	Rooted
2878	Measured	nadh-ubiquinone oxidoreductase 49 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-49kd) (ci-49kd). [swissprot;acc:o75306]
	Ranked
	Squared
	Rooted
2879	Measured	spir-2 protein (fragment). [sptrembl;acc:q8wwl2]
	Ranked
	Squared
	Rooted
2880	Measured	microtubule-interacting protein that associates with traf3; interleukin 13 receptor alpha 1-binding protein-1. [refseq;acc:nm_015650]
	Ranked
	Squared
	Rooted
2881	Measured	collectin sub-family member 12 isoform i; scavenger receptor with c-type lectin; collectin placenta 1; scavenger receptor class a, member 4. [refseq;acc:nm_130386]
	Ranked

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.