MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	description	Value Type	Rank	Interaction Map	green	Network Comparison Type	network_comparison	red	Filtered

Results: HTML CSV LaTeX

Showing element 1 to 50 of 14920 in total

Interaction Map  : High confidence
Network Comparison Type  : Divided

description	Value Type	Rank	green	network_comparison	red	Filtered
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Measured	37	934.348	2.79409	334.401	0
		60	2765.82	1.6231	4489.19	1
	Ranked	18	245.247	1.32082	185.678
		242	13895.8	1.09822	15260.6	0
	Squared	37	1034.13	10.2338	101.05
		245	6768.05	1.31131	8875.01	1
	Rooted	53	18.0183	1.5213	11.844	0
		64	47.2654	1.35128	63.8686	1
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	Measured	509	8630.06	1.14278	7551.8
	Ranked	1038	181.041	1.03148	186.741
	Squared	295	39351.7	1.27733	30807.7
	Rooted	805	79.1513	1.0645	74.3557
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	Measured	508	8636.87	1.14293	7556.75
	Ranked	1032	180.943	1.03162	186.664
	Squared	294	39383.9	1.2776	30826.5
	Rooted	804	79.1931	1.0646	74.3877
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	Measured	514	8532.02	1.1411	7477
	Ranked	1048	182.308	1.031	187.96
	Squared	311	38866.5	1.27154	30566.4
	Rooted	822	78.5795	1.06393	73.8577
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	Measured	513	8543.66	1.14143	7485.08
	Ranked	1043	182.137	1.03128	187.834
	Squared	308	38919.9	1.27205	30596.2
	Rooted	811	78.6514	1.06415	73.9102
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	Measured	3126	0.00001	1	0.00001
	Ranked
	Squared
	Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	Measured	1136	6303.92	1.08864	5790.65
	Ranked	1963	213.703	1.00978	211.633
	Squared	588	27879.3	1.18502	23526.4
	Rooted	1907	65.2789	1.02906	63.4353
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	Measured	2922	0.00001	1	0.00001
	Ranked
	Squared
	Rooted
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]	Measured	1411	6262.07	1.07743	5812.02
	Ranked	2439	221.425	1.00337	220.681
	Squared	1143	32561.8	1.14046	28551.5
	Rooted	1943	63.0838	1.02853	61.3337
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	Measured	3088	0.00001	1	0.00001
	Ranked
	Squared
	Rooted
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	Measured	1415	6265.44	1.0774	5815.33
	Ranked	2396	221.51	1.00375	220.683
	Squared	1135	32641.7	1.14128	28600.9
	Rooted	1961	63.0743	1.02824	61.3419
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	Measured	1600	6788.96	1.07145	6336.22
	Ranked	2366	202.529	1.00407	203.353

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.