MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Value Type	Filtered	green	Interaction Map	Gene	network_comparison	Rank	description	Network Comparison Type	red

Results: HTML CSV LaTeX

Showing element 501 to 550 of 77072 in total

Value Type  : Measured
Filtered  : 0

green	Interaction Map	network_comparison	Rank	description	Network Comparison Type	red
322.947	Low confidence	1.26947	148	williams beuren syndrome critical region 20a isoform 2; nol1/nop2/sun gene family member; williams-beuren syndrome critical region protein 20 copy a; williams beuren syndrome chromosome region 20. [refseq;acc:nm_018044]	Divided	409.972
		87.025	469		Subtracted
323.433		1.26852	150	williams beuren syndrome chromosome region 20c isoform 1. [refseq;acc:nm_032158]	Divided	410.28
		86.847	470		Subtracted
323.685		1.26808	151	williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645]	Divided	410.457
		86.772	471		Subtracted
327.517	High confidence	1.92644	55	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Divided	630.942
		303.425	103		Subtracted
330.189		1.93484	54	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Divided	638.862
		308.673	101		Subtracted
335		1.32937	133	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	Divided	252
		83	314		Subtracted
336.584		1.28908	157	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Divided	261.105
		75.479	319		Subtracted
	Low confidence	1.28908	143		Divided
		75.479	497		Subtracted
339.154	High confidence	1.19069	207	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	Divided	403.827
		64.673	331		Subtracted
339.779	Low confidence	1.06422	485	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]	Divided	361.601
		21.822	733		Subtracted
346.751	High confidence	1.32862	134	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]	Divided	260.986
		85.765	309		Subtracted
351.772		1.76802	68	protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981]	Divided	198.964
		152.808	209		Subtracted
352.75		1.75762	71	ubiquitin protein ligase. [refseq;acc:nm_130466]	Divided	620
		267.25	119		Subtracted
354.349	Low confidence	1.16138	318	poly(rc)-binding protein 2 (alpha-cp2) (hnrnp-e2). [swissprot;acc:q15366]	Divided	305.111
		49.238	599		Subtracted
359.631	High confidence	1.37479	120	signal-induced proliferation-associated 1-like 1. [refseq;acc:nm_015556]	Divided	494.417
		134.786	238		Subtracted
359.98		1.04852	382	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Divided	377.445
		17.465	433		Subtracted
362.023		1.04825	383	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	Divided	379.489
		17.466	432		Subtracted
362.955	Low confidence	1.47569	101	60s ribosomal protein l37a. [swissprot;acc:p12751]	Divided	535.61
		172.655	301		Subtracted
363	High confidence	1.19408	203	microtubule-interacting protein that associates with traf3; interleukin 13 receptor alpha 1-binding protein-1. [refseq;acc:nm_015650]	Divided	304
		59	343		Subtracted
	Low confidence	1.19408	296		Divided
		59	555		Subtracted
368.317	High confidence	1.14829	229	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]	Divided	320.752
		47.565	370		Subtracted
369.011		1.14972	227	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	Divided	424.258
		55.247	349		Subtracted
372.961		1.29544	145	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	Divided	287.903
		85.058	312		Subtracted
375.343	Low confidence	1.21433	179	alanine-glyoxylate aminotransferase 2-like 1. [refseq;acc:nm_031279]	Divided	455.789
		80.446	481		Subtracted
377.574	High confidence	1.29466	146	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	Divided	291.639
		85.935	308		Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.