Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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description Filtered green Value Type Rank Gene Interaction Map red Network Comparison Type network_comparison

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Showing element 501 to 550 of 14920 in total

Interaction Map	High confidence
Network Comparison Type	Divided

description	Filtered	green	Value Type	Rank	red	network_comparison	
6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [source:swissprot;acc:p17858]	1	54.4076	Rooted	1905	52.8713	1.02906	
6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [source:swissprot;acc:p17858]	1	243.085	Ranked	1822	240.32	1.01151	
6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [source:swissprot;acc:p17858]	1	4729.12	Measured	764	4250.18	1.11269	
6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [source:swissprot;acc:p17858]	1	19009.7	Squared	642	16123.9	1.17898	
6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [source:swissprot;acc:p08237]	1	54.4127	Rooted	1894	52.8726	1.02913	
6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [source:swissprot;acc:p08237]	1	243.069	Ranked	1830	240.32	1.01144	
6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [source:swissprot;acc:p08237]	1	4729.67	Measured	763	4250.54	1.11272	
6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [source:swissprot;acc:p08237]	1	19012.6	Squared	643	16126.5	1.17897	
6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [source:swissprot;acc:q01813]	1	54.4715	Rooted	1846	52.887	1.02996	
6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [source:swissprot;acc:q01813]	1	242.881	Ranked	1883	240.317	1.01067	
6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [source:swissprot;acc:q01813]	1	4736.03	Measured	759	4254.62	1.11315	
6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [source:swissprot;acc:q01813]	1	19046	Squared	644	16156.3	1.17886	
6-phosphogluconate dehydrogenase, decarboxylating (ec 1.1.1.44). [source:swissprot;acc:p52209]	1	65.2562	Rooted	2041	63.5421	1.02698	
6-phosphogluconate dehydrogenase, decarboxylating (ec 1.1.1.44). [source:swissprot;acc:p52209]	1	214.801	Ranked	2274	213.642	1.00542	
6-phosphogluconate dehydrogenase, decarboxylating (ec 1.1.1.44). [source:swissprot;acc:p52209]	1	6464.94	Measured	1339	5988.06	1.07964	
6-phosphogluconate dehydrogenase, decarboxylating (ec 1.1.1.44). [source:swissprot;acc:p52209]	1	31257.4	Squared	922	27031.3	1.15634	
6-phosphogluconolactonase (ec 3.1.1.31) (6pgl). [source:swissprot;acc:o95336]	1	64.002	Rooted	2366	62.9164	1.01725	
6-phosphogluconolactonase (ec 3.1.1.31) (6pgl). [source:swissprot;acc:o95336]	1	220.432	Ranked	1584	216.891	1.01633	
6-phosphogluconolactonase (ec 3.1.1.31) (6pgl). [source:swissprot;acc:o95336]	1	6463.9	Measured	1627	6038.46	1.07046	
6-phosphogluconolactonase (ec 3.1.1.31) (6pgl). [source:swissprot;acc:o95336]	1	34004.2	Squared	899	29345.7	1.15875	
6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [source:swissprot;acc:q03393]	1	0.00001	Measured	2904	0.00001	1	
6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [source:swissprot;acc:q03393]	1	0.00001	Ranked	2904	0.00001	1	
6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [source:swissprot;acc:q03393]	1	0.00001	Squared	2904	0.00001	1	
6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [source:swissprot;acc:q03393]	1	0.00001	Rooted	2904	0.00001	1	
60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [source:swissprot;acc:p10809]	1	62.0316	Rooted	1830	60.2038	1.03036	
60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [source:swissprot;acc:p10809]	1	222.64	Ranked	2588	222.305	1.00151	
60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [source:swissprot;acc:p10809]	1	5899.85	Measured	1313	5457.14	1.08112	
60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [source:swissprot;acc:p10809]	1	26712.4	Squared	1238	23538.3	1.13485	
60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [source:swissprot;acc:q92993]	1	65.2371	Rooted	821	61.3164	1.06394	
60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [source:swissprot;acc:q92993]	1	213.912	Ranked	826	223.186	1.04335	
60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [source:swissprot;acc:q92993]	1	6414.98	Measured	1751	6011.57	1.06711	
60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [source:swissprot;acc:q92993]	1	30796.3	Squared	2621	31749.4	1.03095	
60s acidic ribosomal protein p0 (l10e). [source:swissprot;acc:p05388]	1	58.4068	Rooted	2720	58.3416	1.00112	
60s acidic ribosomal protein p0 (l10e). [source:swissprot;acc:p05388]	1	232.855	Ranked	1092	226.203	1.02941	
60s acidic ribosomal protein p0 (l10e). [source:swissprot;acc:p05388]	1	5388.05	Measured	2258	5150.31	1.04616	
60s acidic ribosomal protein p0 (l10e). [source:swissprot;acc:p05388]	1	24581.5	Squared	2254	22719.3	1.08197	
60s acidic ribosomal protein p1. [source:swissprot;acc:p05386]	0	47.6722	Rooted	377	45.8794	1.03908	
60s acidic ribosomal protein p1. [source:swissprot;acc:p05386]	0	6739.34	Measured	313	6131.07	1.09921	
60s acidic ribosomal protein p1. [source:swissprot;acc:p05386]	0	10560	Ranked	233	9586.97	1.1015	
60s acidic ribosomal protein p1. [source:swissprot;acc:p05386]	0	54614.9	Squared	381	49458.1	1.10427	
60s acidic ribosomal protein p1. [source:swissprot;acc:p05386]	1	56.3214	Rooted	2564	56.832	1.00907	
60s acidic ribosomal protein p1. [source:swissprot;acc:p05386]	1	238.048	Ranked	898	229.171	1.03874	
60s acidic ribosomal protein p1. [source:swissprot;acc:p05386]	1	5039.78	Measured	2418	4857.03	1.03763	
60s acidic ribosomal protein p1. [source:swissprot;acc:p05386]	1	22261.9	Squared	2326	20706.1	1.07514	
60s acidic ribosomal protein p2. [source:swissprot;acc:p05387]	1	54.3497	Rooted	1708	56.1247	1.03266	
60s acidic ribosomal protein p2. [source:swissprot;acc:p05387]	1	244.435	Ranked	720	231.92	1.05396	
60s acidic ribosomal protein p2. [source:swissprot;acc:p05387]	1	4813.92	Measured	2743	4824.49	1.0022	
60s acidic ribosomal protein p2. [source:swissprot;acc:p05387]	1	21696.3	Squared	2745	21770.6	1.00342	
60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [source:swissprot;acc:p27635]	0	24.6198	Rooted	261	22.315	1.10328	
60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [source:swissprot;acc:p27635]	0	1367.83	Measured	269	1217.92	1.12309	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/