Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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description Filtered Value Type Rank Gene green Interaction Map Network Comparison Type red network_comparison
Results: HTML CSV LaTeX Showing element 51 to 100 of 14920 in total
Interaction Map	High confidence
Network Comparison Type Divided
description Filtered Value Type Rank green red network_comparison 14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [source:swissprot;acc:p52758] 1 Squared 921 29768.2 25739.7 1.15651 14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [source:swissprot;acc:p52758] 1 Rooted 2036 68.7832 66.966 1.02714 15 kda selenoprotein precursor. [source:swissprot;acc:o60613] 1 Measured 1043 6933.36 6344.41 1.09283 15 kda selenoprotein precursor. [source:swissprot;acc:o60613] 1 Ranked 1948 212.432 214.522 1.00984 15 kda selenoprotein precursor. [source:swissprot;acc:o60613] 1 Squared 914 34456.5 29772.1 1.15734 15 kda selenoprotein precursor. [source:swissprot;acc:o60613] 1 Rooted 1334 67.2624 64.5959 1.04128 15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [source:swissprot;acc:p15428] 1 Measured 2855 0.00001 0.00001 1 15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [source:swissprot;acc:p15428] 1 Ranked 2855 0.00001 0.00001 1 15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [source:swissprot;acc:p15428] 1 Squared 2855 0.00001 0.00001 1 15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [source:swissprot;acc:p15428] 1 Rooted 2855 0.00001 0.00001 1 17 beta-hydroxysteroid dehydrogenase. [source:sptrembl;acc:q13034] 1 Measured 2521 6113.96 5964.17 1.02511 17 beta-hydroxysteroid dehydrogenase. [source:sptrembl;acc:q13034] 1 Ranked 1051 217.998 211.449 1.03097 17 beta-hydroxysteroid dehydrogenase. [source:sptrembl;acc:q13034] 1 Squared 2377 27574.1 25809.5 1.06837 17 beta-hydroxysteroid dehydrogenase. [source:sptrembl;acc:q13034] 1 Rooted 2642 63.5847 63.9773 1.00617 2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [source:swissprot;acc:q9uj83] 1 Measured 1393 6192.72 5743.36 1.07824 2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [source:swissprot;acc:q9uj83] 1 Ranked 2007 222.969 225.019 1.00919 2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [source:swissprot;acc:q9uj83] 1 Squared 1593 32473.8 29261.2 1.10979 2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [source:swissprot;acc:q9uj83] 1 Rooted 1463 62.6331 60.3015 1.03867 2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [source:swissprot;acc:q02218] 1 Measured 2506 6362.25 6200.39 1.0261 2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [source:swissprot;acc:q02218] 1 Ranked 1160 214.041 208.55 1.02633 2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [source:swissprot;acc:q02218] 1 Squared 2426 28847.4 27135.1 1.0631 2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [source:swissprot;acc:q02218] 1 Rooted 2700 65.1252 65.3323 1.00318 2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [source:swissprot;acc:p12694] 1 Measured 2451 6957.34 6737.15 1.03268 2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [source:swissprot;acc:p12694] 1 Ranked 1484 202.726 198.927 1.0191 2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [source:swissprot;acc:p12694] 1 Squared 1699 31699.9 28693.8 1.10476 2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [source:swissprot;acc:p12694] 1 Rooted 2716 69.1987 69.1013 1.00141 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [source:swissprot;acc:p21953] 1 Measured 2288 6048.94 5783.76 1.04585 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [source:swissprot;acc:p21953] 1 Ranked 1389 213.875 218.47 1.02148 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [source:swissprot;acc:p21953] 1 Squared 2488 26643.2 25184.8 1.05791 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [source:swissprot;acc:p21953] 1 Rooted 1579 64.1938 61.9705 1.03588 20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [source:swissprot;acc:p52298] 1 Measured 107 5843.51 4266.04 1.36977 20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [source:swissprot;acc:p52298] 1 Ranked 183 198.011 228.306 1.153 20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [source:swissprot;acc:p52298] 1 Squared 290 20126.8 15734.4 1.27916 20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [source:swissprot;acc:p52298] 1 Rooted 135 66.6101 54.935 1.21253 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [source:swissprot;acc:o15528] 0 Measured 19 26.1599 305.45 11.6763 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [source:swissprot;acc:o15528] 0 Ranked 47 18499.2 12941.7 1.42943 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [source:swissprot;acc:o15528] 0 Squared 26 0.344399 44.3683 128.828 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [source:swissprot;acc:o15528] 0 Rooted 26 3.80565 13.7805 3.62106 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [source:swissprot;acc:o15528] 1 Measured 3079 0.00001 0.00001 1 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [source:swissprot;acc:o15528] 1 Ranked 3079 0.00001 0.00001 1 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [source:swissprot;acc:o15528] 1 Squared 3079 0.00001 0.00001 1 25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [source:swissprot;acc:o15528] 1 Rooted 3079 0.00001 0.00001 1 26s protease regulatory subunit 4 (p26s4). [source:swissprot;acc:q03527] 1 Measured 1521 6376.76 5938.56 1.07379 26s protease regulatory subunit 4 (p26s4). [source:swissprot;acc:q03527] 1 Ranked 2503 216.137 215.581 1.00258 26s protease regulatory subunit 4 (p26s4). [source:swissprot;acc:q03527] 1 Squared 1644 30104.4 27191.5 1.10713 26s protease regulatory subunit 4 (p26s4). [source:swissprot;acc:q03527] 1 Rooted 1870 64.7621 62.901 1.02959 26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [source:swissprot;acc:p17980] 1 Measured 1527 6362.33 5926.76 1.07349 26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [source:swissprot;acc:p17980] 1 Ranked 2474 217.285 216.64 1.00298 26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [source:swissprot;acc:p17980] 1 Squared 1496 30410 27295.8 1.11409 26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [source:swissprot;acc:p17980] 1 Rooted 1916 64.4831 62.679 1.02878 Legend: - Rank is the rank after comparing the two networks - Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions. - Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them - Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions. - Filtered specifies whether we only included the high confidence microarry measurements or not.

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