MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Gene	description	Value Type	Interaction Map	Rank	green	Filtered	Network Comparison Type	network_comparison	red

Results: HTML CSV LaTeX

Showing element 601 to 650 of 7460 in total

Value Type  : Ranked
Interaction Map  : High confidence

description	Rank	green	Filtered	Network Comparison Type	network_comparison	red
alpha adducin (erythrocyte adducin alpha subunit). [swissprot;acc:p35611]	1908	222.258	1	Subtracted	2.174	224.432
	1965			Divided	1.00978
alpha crystallin a chain. [swissprot;acc:p02489]	86	13972.2	0	Subtracted	2400.2	16372.4
	139			Divided	1.17178
	2875	0	1	Subtracted	0	0
		0.00001		Divided	1	0.00001
alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	3082	0		Subtracted	0	0
		0.00001		Divided	1	0.00001
alpha crystallin c chain (small stress protein-like protein hsp22) (e2ig1) (protein kinase h11). [swissprot;acc:q9ujy1]	1397	226.194		Subtracted	4.39	221.804
	1450			Divided	1.01979
alpha enolase (ec 4.2.1.11) (2-phospho-d-glycerate hydro-lyase) (non- neural enolase) (nne) (enolase 1) (phosphopyruvate hydratase). [swissprot;acc:p06733]	2363	208.046			1.00415	207.186
	2365			Subtracted	0.86
alpha-(1,6)-fucosyltransferase (ec 2.4.1.68) (glycoprotein 6-alpha-l- fucosyltransferase) (gdp-fucose--glycoprotein fucosyltransferase) (gdp-l-fuc:n-acetyl-beta-d-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6fuct) (fucosyltransferase 8). [swissprot;acc:q9byc5]	1710	220.53			2.854	217.676
	1726			Divided	1.01311
alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]	418	10866.3	0	Subtracted	319.7	11186
	421			Divided	1.02942
	1189	204.406	1		1.02565	209.649
	1232			Subtracted	5.243
alpha-1-syntrophin (59 kda dystrophin-associated protein a1, acidic component 1) (pro-tgf-alpha cytoplasmic domain-interacting protein 1) (tacip1) (syntrophin 1). [swissprot;acc:q13424]	2587	213.75		Divided	1.00154	213.422
				Subtracted	0.328
alpha-actinin 1 (alpha-actinin cytoskeletal isoform) (non-muscle alpha-actinin 1) (f-actin cross linking protein). [swissprot;acc:p12814]	1791	214.482			2.527	217.009
	1806			Divided	1.01178
alpha-actinin 2 (alpha actinin skeletal muscle isoform 2) (f-actin cross linking protein). [swissprot;acc:p35609]	1787	214.481		Subtracted	2.535	217.016
	1799			Divided	1.01182
alpha-actinin 4 (non-muscle alpha-actinin 4) (f-actin cross linking protein). [swissprot;acc:o43707]	1792	214.482		Subtracted	2.526	217.008
	1805			Divided	1.01178
alpha-centractin (centractin) (centrosome-associated actin homolog) (actin-rpv) (arp1). [swissprot;acc:p42024]	1481	221.177		Subtracted	3.971	225.148
	1509			Divided	1.01795
alpha-fetoprotein enhancer binding protein (at motif-binding factor) (at-binding transcription factor 1). [swissprot;acc:q15911]	2255	203.57			1.00595	202.366
	2257			Subtracted	1.204
alpha-nac protein. [sptrembl;acc:q9h009]	360	14724.5	0		520.1	14204.4
	390			Divided	1.03662
	889	204.053	1		1.03908	212.028
	900			Subtracted	7.975
alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	133	8009	0	Divided	1.17537	6814
	201			Subtracted	1195
	1188	224.7	1		5.346	219.354
	1249			Divided	1.02437
alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]	800	221.785		Subtracted	9.399	212.386
	812			Divided	1.04425
alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]	1931	213.703		Subtracted	2.07	211.633
	1961			Divided	1.00978
alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]	1929			Subtracted	2.07
	1959			Divided	1.00978
alveolar soft part sarcoma chromosome region, candidate 1; aspl protein; renal cell carcinoma gene on chromosome 17; renal cell carcinoma, papillary, 17 gene; aspscr1/tfe3 fusion gene, included. [refseq;acc:nm_024083]	2829	0		Subtracted	0	0
		0.00001		Divided	1	0.00001
amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]	569	242.258		Subtracted	13.619	228.639
	637			Divided	1.05957
aminoacylase-1 (ec 3.5.1.14) (n-acyl-l-amino-acid amidohydrolase) (acy-1). [swissprot;acc:q03154]	1420	208.229			1.02084	203.979
	1424			Subtracted	4.25

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.