MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Gene	description	Rank	Network Comparison Type	Value Type	network_comparison	Filtered	green	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 51 to 100 of 9634 in total

Network Comparison Type  : Divided
Value Type  : Ranked

description	Rank	network_comparison	Filtered	green	Interaction Map	red
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	25	1.20094	1	238.476	Low confidence	286.396
	47	1.42943	0	18499.2	High confidence	12941.7
	384	1.08587		14695.2	Low confidence	13533.1
	3079	1	1	0.00001	High confidence	0.00001
26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	2503	1.00258		216.137		215.581
	2962	1.0169		196.692	Low confidence	200.017
26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [swissprot;acc:p17980]	2474	1.00298		217.285	High confidence	216.64
	2595	1.01795		196.948	Low confidence	200.484
26s protease regulatory subunit 6b (mip224) (mb67 interacting protein) (tat-binding protein-7) (tbp-7). [swissprot;acc:p43686]	1991	1.01951		195.763		199.582
	2327	1.00466		218.426	High confidence	217.413
26s protease regulatory subunit 7 (mss1 protein). [swissprot;acc:p35998]	2321	1.01866		194.732	Low confidence	198.366
	2395	1.00377		219.014	High confidence	218.192
26s protease regulatory subunit 8 (proteasome subunit p45) (thyroid hormone receptor interacting protein 1) (trip1) (msug1 protein) (tat-binding protein homolog 10) (tbp10) (p45/sug). [swissprot;acc:p47210]	1637	1.01479		199.408		202.358
	2163	1.01908		197.22	Low confidence	200.982
26s protease regulatory subunit s10b (proteasome subunit p42) (p44) (conserved atpase domain protein 44) (cadp44). [swissprot;acc:q92524]	2478	1.00289		216.801	High confidence	216.177
	3515	1.01489		197.374	Low confidence	200.312
26s proteasome non-atpase regulatory subunit 1 (26s proteasome regulatory subunit s1) (26s proteasome subunit p112). [swissprot;acc:q99460]	857	1.02575		199.229		204.36
	2368	1.00402		219.434	High confidence	218.555
26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	379	1.03909	0	10806		11228.4
	825	1.00181		11854.2	Low confidence	11832.8
	2269	1.00556	1	218.627	High confidence	217.419
	3038	1.01661		197.031	Low confidence	200.303
26s proteasome non-atpase regulatory subunit 11 (26s proteasome regulatory subunit s9) (26s proteasome regulatory subunit p44.5). [swissprot;acc:o00231]	2174	1.01905		193.995		197.69
	2367	1.00407		218.475	High confidence	217.589
26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232]	495	1.00195	0	11748.1		11725.2
	665	1.02285		11538	Low confidence	11801.6
	2316	1.00493	1	218.311	High confidence	217.241
	3393	1.01532		195.526	Low confidence	198.522
26s proteasome non-atpase regulatory subunit 13 (26s proteasome regulatory subunit s11) (26s proteasome regulatory subunit p40.5). [swissprot;acc:q9unm6]	2329	1.00462		218.116	High confidence	217.112
	2798	1.0173		197.228	Low confidence	200.64
26s proteasome non-atpase regulatory subunit 2 (26s proteasome regulatory subunit s2) (26s proteasome subunit p97) (tumor necrosis factor type 1 receptor associated protein 2) (55.11 protein). [swissprot;acc:q13200]	1918	1.01972		195.527		199.382
	2175	1.00671		208.808	High confidence	210.209
26s proteasome non-atpase regulatory subunit 3 (26s proteasome regulatory subunit s3) (proteasome subunit p58). [swissprot;acc:o43242]	2440	1.00336		218.376		217.645
	2613	1.01785		196.947	Low confidence	200.463
26s proteasome non-atpase regulatory subunit 4 (26s proteasome regulatory subunit s5a) (rpn10) (multiubiquitin chain binding protein) (antisecretory factor-1) (af) (asf). [swissprot;acc:p55036]	1432	1.02028		225.468	High confidence	220.987
	2995	1.01674		196.383	Low confidence	199.67
26s proteasome non-atpase regulatory subunit 6 (26s proteasome regulatory subunit s10) (p42a) (proteasome regulatory particle subunit p44s10). [swissprot;acc:q15008]	1832	1.01997		196.175		200.092
	2432	1.00347		216.556	High confidence	215.807
26s proteasome non-atpase regulatory subunit 7 (26s proteasome regulatory subunit s12) (proteasome subunit p40) (mov34 protein homolog). [swissprot;acc:p51665]	2355	1.00428		218.162		217.232
	3198	1.01604		197.129	Low confidence	200.29
26s proteasome non-atpase regulatory subunit 8 (26s proteasome regulatory subunit s14) (p31). [swissprot;acc:p48556]	1798	1.02014		196.088		200.037
	2525	1.00234		216.341	High confidence	215.835
26s proteasome non-atpase regulatory subunit 9 (26s proteasome regulatory subunit p27). [swissprot;acc:o00233]	2077	1.01928		196.58	Low confidence	200.371
	2620	1.00137		215.91	High confidence	215.615
26s proteasome-associated pad1 homolog. [refseq;acc:nm_005805]	2150	1.00686		219.366		217.871
	2964	1.01688		197.26	Low confidence	200.589
27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	70	1.10425		235.017		259.517
	810	1.04425		221.785	High confidence	212.386
28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	325	1.09941		268.195		243.944
	4510	1.00847		210.759	Low confidence	208.988

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.