MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Interaction Map	Value Type	Filtered	green	Rank	Gene	description	red	Network Comparison Type	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 29840 in total

Interaction Map  : High confidence
Value Type  : Measured
Filtered  : 0

green	Rank	description	red	Network Comparison Type	network_comparison
0	88	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	364	Subtracted	364
	206	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	154		154
	207	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]
	316	ero1-like. [refseq;acc:nm_014584]	82		82
	338	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	60		60
	386	dok-like protein. [refseq;acc:nm_024872]	35		35
	429	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]	18		18
	494	histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261]	0		0
	495	histone h2a.a (h2a/a) (h2a.2). [swissprot;acc:p28001]
	496	mitochondrial 28s ribosomal protein s6 (mrp-s6). [swissprot;acc:p82932]
	497	histone h2a; h2a histone family, member r. [refseq;acc:nm_170745]
	498	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]
	499	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
	500	rwd domain containing 1; ptd013 protein; cgi-24 protein. [refseq;acc:nm_015952]
	501	h2a histone family, member j isoform 1. [refseq;acc:nm_018267]
	502	brca1 associated protein. [refseq;acc:nm_006768]
0.00001	1	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	364	Divided	36400000
	20	ero1-like. [refseq;acc:nm_014584]	82		8200000
	22	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	60		6000000
	31	dok-like protein. [refseq;acc:nm_024872]	35		3500000
	65	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]	18		1800000
	95	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	154		15400000
	96	transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]
	494	histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261]	0.00001		1
	495	histone h2a.a (h2a/a) (h2a.2). [swissprot;acc:p28001]
	496	mitochondrial 28s ribosomal protein s6 (mrp-s6). [swissprot;acc:p82932]
	497	histone h2a; h2a histone family, member r. [refseq;acc:nm_170745]
	498	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]
	499	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
	500	rwd domain containing 1; ptd013 protein; cgi-24 protein. [refseq;acc:nm_015952]
	501	h2a histone family, member j isoform 1. [refseq;acc:nm_018267]
	502	brca1 associated protein. [refseq;acc:nm_006768]
5.56738	11	serpin b12. [swissprot;acc:q96p63]	199.549		35.8425
	168			Subtracted	193.982
5.71669	12	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	199.249	Divided	34.8539
	169			Subtracted	193.532
6.50325	14	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	130.512	Divided	20.0687
	258			Subtracted	124.009
11.5	190	protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0]	14	Divided	1.21739
	489			Subtracted	2.5
14.3333	121	4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]	19.6667	Divided	1.3721
	460			Subtracted	5.3334
15	16	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	1	Divided	15
	443			Subtracted	14
17.6611	21	syntaxin 10 (syn10). [swissprot;acc:o60499]	118.878	Divided	6.73106
	269			Subtracted	101.217
18	64	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]	0.00001	Divided	1800000
	428		0	Subtracted	18
19	195	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]	23	Divided	1.21053
	464			Subtracted	4

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.