Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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description Gene Rank Interaction Map Filtered Value Type Network Comparison Type network_comparison red green
Results: HTML CSV LaTeX Showing element 1 to 50 of 19268 in total
Value Type  : Measured
description
Rank
Interaction Map
Filtered
Network Comparison Type
network_comparison
red
green
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] 37 High confidence 0 Divided 2.79409 334.401 934.348
45 Subtracted 599.947
60 1 Divided 1.6231 4489.19 2765.82
131 Low confidence 0 1.31954 645.504 851.77
164 High confidence 1 Subtracted 1723.37 4489.19 2765.82
273 Low confidence 0 206.266 645.504 851.77
4909 1 46.92 7853.62 7900.54
4914 Divided 1.00597
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943] 310 High confidence Subtracted 1078.26 7551.8 8630.06
509 Divided 1.14278
780 Low confidence Subtracted 329.69 8255.95 8585.64
885 Divided 1.03993
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120] 307 High confidence Subtracted 1080.12 7556.75 8636.87
508 Divided 1.14293
773 Low confidence Subtracted 330.35 8256.68 8587.03
880 Divided 1.04001
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5] 210 Subtracted 550.78 8530.51 9081.29
237 Divided 1.06457
319 High confidence Subtracted 1055.02 7477 8532.02
514 Divided 1.1411
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7] 230 Low confidence Subtracted 526.02 8492.92 9018.94
252 Divided 1.06194
318 High confidence Subtracted 1058.58 7485.08 8543.66
513 Divided 1.14143
1-aminocyclopropane-1-carboxylate synthase. [refseq;acc:nm_032592] 1941 Low confidence Subtracted 257.99 8065.05 8323.04
2035 Divided 1.03199
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147] 2882 1.02859 7948.01 8175.27
2902 Subtracted 227.26
3126 High confidence Divided 1 0.00001 0.00001
Subtracted 0 0 0
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984] 1136 Divided 1.08864 5790.65 6303.92
1140 Subtracted 513.27
2020 Low confidence 255.96 8130.62 8386.58
2182 Divided 1.03148
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891] 1693 1.03323 7981.12 8246.34
1700 Subtracted 265.22
2922 High confidence Divided 1 0.00001 0.00001
Subtracted 0 0 0
130 kda leucine-rich protein (lrp 130) (gp130) (leucine-rich ppr-motif containing protein). [swissprot;acc:p42704] 4071 Low confidence Divided 1.02166 7896.47 8067.47
4228 Subtracted 171
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946] 490 392.59 8572.9 8965.49
575 Divided 1.04579
1411 High confidence 1.07743 5812.02 6262.07
1422 Subtracted 450.05
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655] 2941 Low confidence 225.73 8144.39 8370.12
3088 High confidence Divided 1 0.00001 0.00001
Subtracted 0 0 0
3095 Low confidence Divided 1.02772 8144.39 8370.12
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312] 498 Subtracted 390.81 8566.17 8956.98
591 Divided 1.04562

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/