MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Value Type	Filtered	green	Interaction Map	Gene	Rank	description	network_comparison	red	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 501 to 550 of 77072 in total

Value Type  : Measured
Filtered  : 0

green	Interaction Map	Rank	description	network_comparison	red	Network Comparison Type
322.947	Low confidence	148	williams beuren syndrome critical region 20a isoform 2; nol1/nop2/sun gene family member; williams-beuren syndrome critical region protein 20 copy a; williams beuren syndrome chromosome region 20. [refseq;acc:nm_018044]	1.26947	409.972	Divided
		469		87.025		Subtracted
323.433		150	williams beuren syndrome chromosome region 20c isoform 1. [refseq;acc:nm_032158]	1.26852	410.28	Divided
		470		86.847		Subtracted
323.685		151	williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645]	1.26808	410.457	Divided
		471		86.772		Subtracted
327.517	High confidence	55	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	1.92644	630.942	Divided
		103		303.425		Subtracted
330.189		54	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	1.93484	638.862	Divided
		101		308.673		Subtracted
335		133	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	1.32937	252	Divided
		314		83		Subtracted
336.584		157	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	1.28908	261.105	Divided
		319		75.479		Subtracted
	Low confidence	143		1.28908		Divided
		497		75.479		Subtracted
339.154	High confidence	207	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	1.19069	403.827	Divided
		331		64.673		Subtracted
339.779	Low confidence	485	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]	1.06422	361.601	Divided
		733		21.822		Subtracted
346.751	High confidence	134	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]	1.32862	260.986	Divided
		309		85.765		Subtracted
351.772		68	protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981]	1.76802	198.964	Divided
		209		152.808		Subtracted
352.75		71	ubiquitin protein ligase. [refseq;acc:nm_130466]	1.75762	620	Divided
		119		267.25		Subtracted
354.349	Low confidence	318	poly(rc)-binding protein 2 (alpha-cp2) (hnrnp-e2). [swissprot;acc:q15366]	1.16138	305.111	Divided
		599		49.238		Subtracted
359.631	High confidence	120	signal-induced proliferation-associated 1-like 1. [refseq;acc:nm_015556]	1.37479	494.417	Divided
		238		134.786		Subtracted
359.98		382	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	1.04852	377.445	Divided
		433		17.465		Subtracted
362.023		383	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	1.04825	379.489	Divided
		432		17.466		Subtracted
362.955	Low confidence	101	60s ribosomal protein l37a. [swissprot;acc:p12751]	1.47569	535.61	Divided
		301		172.655		Subtracted
363	High confidence	203	microtubule-interacting protein that associates with traf3; interleukin 13 receptor alpha 1-binding protein-1. [refseq;acc:nm_015650]	1.19408	304	Divided
		343		59		Subtracted
	Low confidence	296		1.19408		Divided
		555		59		Subtracted
368.317	High confidence	229	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]	1.14829	320.752	Divided
		370		47.565		Subtracted
369.011		227	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	1.14972	424.258	Divided
		349		55.247		Subtracted
372.961		145	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	1.29544	287.903	Divided
		312		85.058		Subtracted
375.343	Low confidence	179	alanine-glyoxylate aminotransferase 2-like 1. [refseq;acc:nm_031279]	1.21433	455.789	Divided
		481		80.446		Subtracted
377.574	High confidence	146	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	1.29466	291.639	Divided
		308		85.935		Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.