MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Filtered	Value Type	green	Rank	Gene	description	network_comparison	Network Comparison Type	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 451 to 500 of 77072 in total

Filtered  : 0
Value Type  : Measured

green	Rank	description	network_comparison	Network Comparison Type	Interaction Map	red
206.5	434	testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [swissprot;acc:p16562]	1.02736	Divided	High confidence	201
	459		5.5	Subtracted
210	117	helicase/primase complex protein. [refseq;acc:nm_138336]	1.35238	Divided	Low confidence	284
	504		74	Subtracted
219.891	392	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	1.04238	Divided	High confidence	229.211
	452		9.32	Subtracted
221.565	469	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	1.00822	Divided		219.759
	490		1.806	Subtracted
224.096	94	myosin vi. [swissprot;acc:q9um54]	1.54338	Divided		345.865
	95				Low confidence
	259		121.769	Subtracted	High confidence
	395				Low confidence
226.797	399	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	1.10398	Divided		250.379
	723		23.582	Subtracted
226.81	410	glycerol kinase, testis specific 2 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14410]	1.03704	Divided	High confidence	218.71
	456		8.1	Subtracted
227.143	408	glycerol kinase, testis specific 1 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14409]	1.03704	Divided		219.031
	455		8.112	Subtracted
227.308	409	glycerol kinase (ec 2.7.1.30) (atp:glycerol 3-phosphotransferase) (glycerokinase) (gk). [swissprot;acc:p32189]	1.03704	Divided		219.19
	454		8.118	Subtracted
234.276	94	poly (adp-ribose) glycohydrolase. [refseq;acc:nm_003631]	1.54599	Divided	Low confidence	362.189
	379		127.913	Subtracted
241.74	120	proactivator polypeptide precursor [contains: saposin a (protein a); saposin b (sphingolipid activator protein 1) (sap-1) (cerebroside sulfate activator) (csact) (dispersin) (sulfatide/gm1 activator); saposin c (co-beta-glucosidase) (a1 activator) (glucosylceramidase activator) (sphingolipid activator protein 2) (sap-2); saposin d (protein c) (component c)]. [swissprot;acc:p07602]	1.3378	Divided		180.7
	547		61.04	Subtracted
249.857	487	ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154]	1.00225	Divided	High confidence	250.419
	488	ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]
	492	ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154]	0.562	Subtracted
	493	ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]
268.468	572	transcription factor bteb4 (basic transcription element binding- protein 4) (bte-binding protein 4) (krueppel-like factor 16) (novel sp1-like zinc finger transcription factor 2) (transcription factor nslp2). [swissprot;acc:q9bxk1]	1.04582	Divided	Low confidence	280.768
	781		12.3	Subtracted
277.003	168	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	1.23006	Divided		340.73
	542		63.727	Subtracted
279.24	59	f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755]	1.85328	Divided	High confidence	150.673
	246		128.567	Subtracted
290.667	103	transketolase-like 1 (ec 2.2.1.1) (transketolase 2) (tk 2) (transketolase related protein). [swissprot;acc:p51854]	1.47298	Divided		197.333
	283		93.334	Subtracted
299.876	84	sedlin. [swissprot;acc:o14582]	1.64861	Divided	Low confidence	181.896
	402		117.98	Subtracted
305.886	70	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	1.82368	Divided		167.73
	355		138.156	Subtracted
306.727	183	blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	1.22281	Divided	High confidence	375.07
	184	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]
	326	blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	68.343	Subtracted
	327	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]
306.933	185		1.22281	Divided		375.322
	325		68.389	Subtracted
315.505	59	nadph oxidase, ef hand calcium-binding domain 5. [refseq;acc:nm_024505]	2.14473	Divided	Low confidence	147.107
	309		168.398	Subtracted
315.567	60	nadph oxidase homolog 1 (nox-1) (noh-1) (nadh/nadph mitogenic oxidase subunit p65-mox) (mitogenic oxidase 1) (mox1). [swissprot;acc:q9y5s8]	2.14463	Divided		147.143
	308		168.424	Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.