Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Filtered Value Type green Rank Gene description network_comparison Network Comparison Type Interaction Map red
Results: HTML CSV LaTeX Showing element 451 to 500 of 77072 in total
Filtered  : 0
Value Type  : Measured
green
Rank
description
network_comparison
Network Comparison Type
Interaction Map
red
206.5 434 testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [swissprot;acc:p16562] 1.02736 Divided High confidence 201
459 5.5 Subtracted
210 117 helicase/primase complex protein. [refseq;acc:nm_138336] 1.35238 Divided Low confidence 284
504 74 Subtracted
219.891 392 60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914] 1.04238 Divided High confidence 229.211
452 9.32 Subtracted
221.565 469 transcription factor btf3 homolog 3. [swissprot;acc:q13892] 1.00822 Divided 219.759
490 1.806 Subtracted
224.096 94 myosin vi. [swissprot;acc:q9um54] 1.54338 Divided 345.865
95 Low confidence
259 121.769 Subtracted High confidence
395 Low confidence
226.797 399 similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517] 1.10398 Divided 250.379
723 23.582 Subtracted
226.81 410 glycerol kinase, testis specific 2 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14410] 1.03704 Divided High confidence 218.71
456 8.1 Subtracted
227.143 408 glycerol kinase, testis specific 1 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14409] 1.03704 Divided 219.031
455 8.112 Subtracted
227.308 409 glycerol kinase (ec 2.7.1.30) (atp:glycerol 3-phosphotransferase) (glycerokinase) (gk). [swissprot;acc:p32189] 1.03704 Divided 219.19
454 8.118 Subtracted
234.276 94 poly (adp-ribose) glycohydrolase. [refseq;acc:nm_003631] 1.54599 Divided Low confidence 362.189
379 127.913 Subtracted
241.74 120 proactivator polypeptide precursor [contains: saposin a (protein a); saposin b (sphingolipid activator protein 1) (sap-1) (cerebroside sulfate activator) (csact) (dispersin) (sulfatide/gm1 activator); saposin c (co-beta-glucosidase) (a1 activator) (glucosylceramidase activator) (sphingolipid activator protein 2) (sap-2); saposin d (protein c) (component c)]. [swissprot;acc:p07602] 1.3378 Divided 180.7
547 61.04 Subtracted
249.857 487 ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154] 1.00225 Divided High confidence 250.419
488 ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]
492 ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154] 0.562 Subtracted
493 ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]
268.468 572 transcription factor bteb4 (basic transcription element binding- protein 4) (bte-binding protein 4) (krueppel-like factor 16) (novel sp1-like zinc finger transcription factor 2) (transcription factor nslp2). [swissprot;acc:q9bxk1] 1.04582 Divided Low confidence 280.768
781 12.3 Subtracted
277.003 168 transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186] 1.23006 Divided 340.73
542 63.727 Subtracted
279.24 59 f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755] 1.85328 Divided High confidence 150.673
246 128.567 Subtracted
290.667 103 transketolase-like 1 (ec 2.2.1.1) (transketolase 2) (tk 2) (transketolase related protein). [swissprot;acc:p51854] 1.47298 Divided 197.333
283 93.334 Subtracted
299.876 84 sedlin. [swissprot;acc:o14582] 1.64861 Divided Low confidence 181.896
402 117.98 Subtracted
305.886 70 synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296] 1.82368 Divided 167.73
355 138.156 Subtracted
306.727 183 blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161] 1.22281 Divided High confidence 375.07
184 blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]
326 blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161] 68.343 Subtracted
327 blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]
306.933 185 1.22281 Divided 375.322
325 68.389 Subtracted
315.505 59 nadph oxidase, ef hand calcium-binding domain 5. [refseq;acc:nm_024505] 2.14473 Divided Low confidence 147.107
309 168.398 Subtracted
315.567 60 nadph oxidase homolog 1 (nox-1) (noh-1) (nadh/nadph mitogenic oxidase subunit p65-mox) (mitogenic oxidase 1) (mox1). [swissprot;acc:q9y5s8] 2.14463 Divided 147.143
308 168.424 Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/