Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene Interaction Map Value Type description Network Comparison Type Filtered green network_comparison red
Results: HTML CSV LaTeX Showing element 1 to 50 of 25824 in total
Interaction Map  : High confidence
Filtered  : 1
Rank
Value Type
description
Network Comparison Type
green
network_comparison
red
1 Measured mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] Subtracted 33356.5 8126 41482.5
rad50-interacting protein 1. [refseq;acc:nm_021930] Divided 2394.5 5.31521 450.5
Ranked homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774] Subtracted 322 107 215
putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172] Divided 24 2.4 10
Squared Subtracted 322755 145743 468498
rad50-interacting protein 1. [refseq;acc:nm_021930] Divided 1357.07 28.2513 48.0356
Rooted 48.9336 2.30547 21.225
Subtracted 27.7086
2 Measured cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] 33356.5 8126 41482.5
rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6] Divided 2394.5 5.31521 450.5
Ranked hbs1-like. [refseq;acc:nm_006620] Subtracted 322 107 215
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] Divided 28 1.86667 15
Squared Subtracted 263351 143938 407289
rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6] Divided 1357.07 28.2513 48.0356
Rooted 48.9336 2.30547 21.225
Subtracted 27.7086
3 Measured cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418] 33356.5 8126 41482.5
homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774] Divided 698.5 3.71868 2597.5
Ranked cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] 28 1.86667 15
rad50-interacting protein 1. [refseq;acc:nm_021930] Subtracted 232 105 337
Squared cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] 263351 143938 407289
homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774] Divided 115.48 13.8285 1596.92
Rooted 26.4292 1.92839 50.9657
Subtracted 24.5365
4 Measured cytohesin 4. [swissprot;acc:q9uia0] 33356.5 8126 41482.5
hbs1-like. [refseq;acc:nm_006620] Divided 698.5 3.71868 2597.5
Ranked cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418] 28 1.86667 15
rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6] Subtracted 232 105 337
Squared cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418] 263351 143938 407289
hbs1-like. [refseq;acc:nm_006620] Divided 115.48 13.8285 1596.92
Rooted 26.4292 1.92839 50.9657
Subtracted 24.5365
5 Measured cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739] 33356.5 8126 41482.5
junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2] Divided 339.5 3.39764 1153.5
Ranked cytohesin 4. [swissprot;acc:q9uia0] 28 1.86667 15
xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266] Subtracted 309 97 212
Squared cytohesin 4. [swissprot;acc:q9uia0] 263351 143938 407289
junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2] Divided 27.2805 11.544 314.926
Rooted 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5] Subtracted 168.796 23.245 145.551
junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2] Divided 18.4255 1.84327 33.9632
6 Measured junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39] 339.5 3.39764 1153.5
putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172] Subtracted 36927.5 7563 44490.5
Ranked cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739] Divided 28 1.86667 15
protein x 0004. [refseq;acc:nm_016301] Subtracted 309 97 212
Squared cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739] 263351 143938 407289
junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39] Divided 27.2805 11.544 314.926
Rooted 18.4255 1.84327 33.9632
pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04] Subtracted 168.796 23.245 145.551
7 Measured 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5] 28492 7307 21185
sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906] Divided 339.5 3.39764 1153.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/