MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1568 to 1617 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
784	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	Divided	224.385	235.131	1.04789
785	neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863]		244.447	233.508	1.04685
	pwwp domain containing 1; hdgf (hepatoma-derived growth factor) like. [refseq;acc:nm_138574]	Subtracted	231.734	222.222	9.512
786	probable atp-dependent rna helicase p54 (oncogene rck) (dead-box protein 6). [swissprot;acc:p26196]
	rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555]	Divided	244.447	233.508	1.04685
787	down-regulated in metastasis. [refseq;acc:nm_014503]
	rw1 protein (fragment). [swissprot;acc:q92545]	Subtracted	231.734	222.222	9.512
788	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	Divided	138.705	132.538	1.04653
	loh1cr12. [refseq;acc:nm_058169]	Subtracted	230.087	220.579	9.508
789	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]	Divided	224.244	234.511	1.04578
	unr protein. [swissprot;acc:o75534]	Subtracted	230.087	220.579	9.508
790	40s ribosomal protein s21. [swissprot;acc:p35265]	Divided	224.244	234.511	1.04578
	testis-specific protein tex28. [swissprot;acc:o15482]	Subtracted	212.386	221.785	9.399
791	cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [swissprot;acc:p50453]	Divided	224.244	234.511	1.04578
	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]	Subtracted	212.386	221.785	9.399
792	a kindred of iglon. [refseq;acc:nm_173808]
	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	Divided	224.244	234.511	1.04578
793	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	Subtracted	212.386	221.785	9.399
	bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	Divided	224.244	234.511	1.04578
794	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	Subtracted	212.386	221.785	9.399
	plasminogen activator inhibitor-2 precursor (pai-2) (placental plasminogen activator inhibitor) (monocyte arg-serpin) (urokinase inhibitor). [swissprot;acc:p05120]	Divided	224.244	234.511	1.04578
795	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	Subtracted	212.386	221.785	9.399
	serpin b11. [swissprot;acc:q96p15]	Divided	224.244	234.511	1.04578
796	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]	Subtracted	212.386	221.785	9.399
	placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237]	Divided	224.244	234.511	1.04578
797	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
	syntaxin 16 (syn16). [swissprot;acc:o14662]	Subtracted	212.386	221.785	9.399
798	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]
	leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740]	Divided	224.244	234.511	1.04578
799	sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900]		221.965	212.404	1.04501
	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	Subtracted	212.386	221.785	9.399
800	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]
	nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307]	Divided	221.965	212.404	1.04501
801	adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	Subtracted	212.386	221.785	9.399
	beta-catenin (pro2286). [swissprot;acc:p35222]	Divided	224.445	214.894	1.04445
802	synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721]	Subtracted	212.386	221.785	9.399
	testis-specific protein tex28. [swissprot;acc:o15482]	Divided			1.04425
803	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]
	syntaxin 1b. [swissprot;acc:q15531]	Subtracted			9.399
804	a kindred of iglon. [refseq;acc:nm_173808]	Divided			1.04425
	melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084]	Subtracted			9.399
805	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	Divided			1.04425
	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593]	Subtracted			9.399
806	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	Divided			1.04425
	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	Subtracted	267.447	276.773	9.326
807	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	Divided	212.386	221.785	1.04425
	trifunctional purine biosynthetic protein adenosine-3 [includes: phosphoribosylamine--glycine ligase (ec 6.3.4.13) (gars) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); phosphoribosylformylglycinamidine cyclo-ligase (ec 6.3.3.1) (airs) (phosphoribosyl-aminoimidazole synthetase) (air synthase); phosphoribosylglycinamide formyltransferase (ec 2.1.2.2) (gart) (gar transformylase) (5'-phosphoribosylglycinamide transformylase)]. [swissprot;acc:p22102]	Subtracted	218.521	227.796	9.275
808	60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]		223.186	213.912	9.274
	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]	Divided	212.386	221.785	1.04425
809	diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602]	Subtracted	233.298	242.571	9.273

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.