MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Value Type	Rank	Gene	Hugo	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1013 to 1062 of 12912 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	red	green	network_comparison
1013	HEYL	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	5791.82	6340.86	1.0948
1014	SYN2	synapsin ii. [swissprot;acc:q92777]
1015	MRRF	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]
1016	PEX5	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]
1017	HEY2	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]
1018	HES1	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]
1019	ECH1	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]
1020	ABLIM1	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]
1021	SYN1	synapsin i (brain protein 4.1). [swissprot;acc:p17600]
1022	CLK2	protein kinase clk2 (ec 2.7.1.-) (cdc-like kinase 2). [swissprot;acc:p49760]	6435.94	7045.75	1.09475
1023	CLK3	protein kinase clk3 (ec 2.7.1.-) (cdc-like kinase 3). [swissprot;acc:p49761]	6435.02	7044.65	1.09474
1024	no value	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]	5706.5	6245.55	1.09446
1025	PMM2	phosphomannomutase 2 (ec 5.4.2.8) (pmm 2). [swissprot;acc:o15305]	5511.96	6031.95	1.09434
1026	PMM1	phosphomannomutase 1 (ec 5.4.2.8) (pmm 1) (pmmh-22). [swissprot;acc:q92871]	5509.89	6029.29	1.09427
1027	MAT2A	s-adenosylmethionine synthetase gamma form (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-ii). [swissprot;acc:p31153]	6123.15	6700.05	1.09422
1028	QPRT	nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274]	5704	6241.36	1.09421
1029	CTNNB1	beta-catenin (pro2286). [swissprot;acc:p35222]	5635.26	6166.09	1.0942
1030	no value	casein kinase i, epsilon isoform (ec 2.7.1.-) (cki-epsilon) (ckie). [swissprot;acc:p49674]	5048.33	5523.85	1.09419
1031	FAM57A	membrane protein expressed in epithelial-like lung adenocarcinoma. [refseq;acc:nm_024792]	6136.99	6714.98	1.09418
1032	IPO11	ran binding protein 11. [refseq;acc:nm_016338]	6138.91	6717.05
1033	FBP2	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	6080.91	6653.52	1.09417
1034	MAT1A	s-adenosylmethionine synthetase alpha and beta forms (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-i/iii). [swissprot;acc:q00266]	6152.88	6732.12	1.09414
1035	CSNK1D	casein kinase i, delta isoform (ec 2.7.1.-) (cki-delta) (ckid). [swissprot;acc:p48730]	5054.73	5530.23	1.09407
1036	FBP1	fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]	6077.65	6649.22	1.09404
1037	MGLL	monoglyceride lipase; lysophospholipase-like. [refseq;acc:nm_007283]	6544.26	7159.43	1.094
1038	MYB	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	5417.95	5924.41	1.09348
1039	MYBL2	myb-related protein b (b-myb). [swissprot;acc:p10244]	5418.92	5923.09	1.09304
1040	RBM39	rna-binding region containing protein 2 (hepatocellular carcinoma protein 1) (splicing factor hcc1). [swissprot;acc:q14498]	5421.93	5926.08	1.09298
1041	MYBL1	myb-related protein a (a-myb). [swissprot;acc:p10243]	5419.18	5922.84	1.09294
1042	LIMCH1	similar to lim domain only 7 (fragment). [sptrembl;acc:q8n6m2]	5887.52	6434.32	1.09287
1043	no value	15 kda selenoprotein precursor. [swissprot;acc:o60613]	6344.41	6933.36	1.09283
1044	MIZF	mbd2 (methyl-cpg-binding protein)-interacting zinc finger protein. [refseq;acc:nm_015517]	4757.46	5198.91	1.09279
1045	ICT1	immature colon carcinoma transcript 1 (digestion substraction 1) (ds- 1). [swissprot;acc:q14197]	5364.32	5862.09
1046	TMOD4	skeletal muscle tropomodulin (sk-tmod) (tropomodulin 4). [swissprot;acc:q9nzq9]	4757.46	5198.91
1047	TMOD3	ubiquitous tropomodulin (u-tmod) (tropomodulin 3). [swissprot;acc:q9nyl9]
1048	TMOD1	tropomodulin 1 (erythrocyte tropomodulin) (e-tmod). [swissprot;acc:p28289]
1049	SNX9	sorting nexin 9 (sh3 and px domain-containing protein 1) (sdp1 protein). [swissprot;acc:q9y5x1]
1050	TMOD2	neuronal tropomodulin (n-tmod) (tropomodulin 2). [swissprot;acc:q9nzr1]
1051	DLX2	homeobox protein dlx-2. [swissprot;acc:q07687]
1052	DLX5	homeobox protein dlx-5. [swissprot;acc:p56178]
1053	MPPED2	fetal brain protein 239 (239fb). [swissprot;acc:q15777]
1054	DLX3	homeobox protein dlx-3. [swissprot;acc:o60479]
1055	TNK2	activated p21cdc42hs kinase. [refseq;acc:nm_005781]
1056	MAP3K7IP2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2 isoform 1; tak1-binding protein 2. [refseq;acc:nm_015093]
1057	TMF1	tata element modulatory factor (tmf). [swissprot;acc:p82094]	5412.23	5913.4	1.0926
1058	SCYL1	scy1-like 1; telomerase regulation-associated protein; ht019 protein; telomerase regulation-associated protein; n-terminal kinase-like protein; teratoma-associated tyrosine kinase; n-terminal kinase-like. [refseq;acc:nm_020680]
1059	TBCC	tubulin-specific chaperone c (tubulin-folding cofactor c) (cfc). [swissprot;acc:q15814]	5719.01	6248.6
1060	ACOT9	putative acyl-coa thioester hydrolase cgi-16 (ec 3.1.2.-). [swissprot;acc:q9y305]
1061	NUP98	nuclear pore complex protein nup98 (nucleoporin nup98) (98 kda nucleoporin). [swissprot;acc:p52948]	5412.23	5913.4
1062	AMMECR1	ammecr1 protein. [refseq;acc:nm_015365]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.