MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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description	Rank	Gene	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 901 to 950 of 3228 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

description	Rank	red	green	network_comparison
e1b-55kda-associated protein 5 isoform a. [refseq;acc:nm_007040]	2693	4113.79	4095.53	1.00446
e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	494	5979.93	6842.72	1.14428
eap30 subunit of ell complex. [refseq;acc:nm_007241]	497	4682.87	4093.05	1.1441
early endosome antigen 1, 162kd; early endosome-associated protein. [refseq;acc:nm_003566]	2151	4871.11	5129.63	1.05307
ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	651	5168.43	4597.44	1.1242
ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_005665]	1235	5807.83	6300.47	1.08482
ecotropic virus integration 1 site protein. [swissprot;acc:q03112]	3170	0.00001	0.00001	1
egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	1481	3688.8	3431.33	1.07504
eh-domain containing protein 1 (testilin) (hpast1). [swissprot;acc:q9h4m9]	2514	6203.92	6360.25	1.0252
eh-domain containing protein 2. [swissprot;acc:q9nzn4]	2517	6203.96	6360.24	1.02519
eh-domain containing protein 3. [swissprot;acc:q9nzn3]	2515	6203.94	6360.25	1.0252
eh-domain containing protein 4 (eh domain-containing protein fksg7) (hepatocellular carcinoma-associated protein 10/11). [swissprot;acc:q9h223]	2516	6203.95	6360.24	1.02519
eif-5a2 protein. [refseq;acc:nm_020390]	1610	6222.4	6665.83	1.07126
elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]	2206	5076.73	5326.29	1.04916
elav-like protein 1 (hu-antigen r) (hur). [swissprot;acc:q15717]	2178	5893.23	6193.33	1.05092
elav-like protein 2 (hu-antigen b) (hub) (elav-like neuronal protein 1) (nervous system-specific rna binding protein hel-n1). [swissprot;acc:q12926]	2180	5900.25	6200.24	1.05084
elav-like protein 3 (hu-antigen c) (huc) (paraneoplastic cerebellar degeneration-associated antigen) (paraneoplastic limbic encephalitis antigen 21). [swissprot;acc:q14576]	2177	5887.43	6187.82	1.05102
elav-like protein 4 (paraneoplastic encephalomyelitis antigen hud) (hu-antigen d). [swissprot;acc:p26378]	2179	5896.51	6196.59	1.05089
electron transfer flavoprotein alpha-subunit, mitochondrial precursor (alpha-etf). [swissprot;acc:p13804]	1749	7919.76	8452.01	1.06721
electron transfer flavoprotein beta-subunit (beta-etf). [swissprot;acc:p38117]	1761	7794.41	8316.04	1.06692
electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (ec 1.5.5.1) (etf-qo) (etf-ubiquinone oxidoreductase) (etf dehydrogenase) (electron-transferring- flavoprotein dehydrogenase). [swissprot;acc:q16134]	1301	6618.74	7161.67	1.08203
elks protein. [refseq;acc:nm_015064]	1163	5832.13	6343.59	1.0877
ell-associated factor 2; uncharacterized bone marrow protein bm040; testosterone regulated apoptosis inducer and tumor suppressor. [refseq;acc:nm_018456]	2921	0.00001	0.00001	1
elongation factor 1-alpha 1 (ef-1-alpha-1) (elongation factor 1 a-1) (eef1a-1) (elongation factor tu) (ef-tu). [swissprot;acc:p04720]	1733	5874.83	6272.26	1.06765
elongation factor 1-alpha 2 (ef-1-alpha-2) (elongation factor 1 a-2) (eef1a-2) (statin s1). [swissprot;acc:q05639]	1735
elongation factor 2 (ef-2). [swissprot;acc:p13639]	1069	5494.73	6001.08	1.09215
elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897]	3027	0.00001	0.00001	1
elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60]	458	4890.55	5610.96	1.14731
elongation protein 4 homolog; pax6 neighbor gene; chromosome 11 open reading frame 19. [refseq;acc:nm_019040]	1344	5887.86	6354.5	1.07925
endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759]	520	9642.22	10986.4	1.13941
endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]	2695	5176.92	5154.43	1.00436
endosome-associated fyve-domain protein. [refseq;acc:nm_014733]	3200	0.00001	0.00001	1
endothelial-derived gene 1. [refseq;acc:nm_025205]	1807	6399.54	6818.17	1.06542
enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	202	4812.01	6076.09	1.26269
enhancer of rudimentary homolog. [swissprot;acc:q14259]	2072	6437.24	6797.24	1.05592
enhancer of zeste homolog 1 (enx-2). [swissprot;acc:q92800]	3090	0.00001	0.00001	1
enhancer of zeste homolog 2 (enx-1). [swissprot;acc:q15910]	3098
enigma protein; lim domain protein. [refseq;acc:nm_005451]	1596	5665.34	6070.32	1.07148
enoyl-coa hydratase, mitochondrial precursor (ec 4.2.1.17) (short chain enoyl-coa hydratase) (sceh) (enoyl-coa hydratase 1). [swissprot;acc:p30084]	504	10067.9	11511	1.14334
enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	347	4991.02	5885.09	1.17914
enthoprotin; epsin 4; clathrin interacting protein localized in the trans-golgi region. [refseq;acc:nm_014666]	2022	5520.26	5841.16	1.05813
epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]	1261	5685.34	6157.53	1.08305
epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	1259	5685.38	6157.7	1.08308
epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	1270	5685.08	6156.48	1.08292
epidermal growth factor receptor precursor (ec 2.7.1.112) (receptor protein-tyrosine kinase erbb-1). [swissprot;acc:p00533]	1391	5743.36	6192.7	1.07824
epididymal secretory protein e1 precursor (niemann-pick disease type c2 protein) (epi-1) (he1) (epididymal secretory protein 14.6) (esp14.6). [swissprot;acc:q15668]	872	6781.05	7480.15	1.1031
epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	2173	3641.4	3462.96	1.05153
epoxide hydrolase 1 (ec 3.3.2.3) (microsomal epoxide hydrolase) (epoxide hydratase). [swissprot;acc:p07099]	1573	11785.4	10995.3	1.07186
epsin 1; eh domain-binding mitotic phosphoprotein. [refseq;acc:nm_013333]	1801	5881.33	6268.57	1.06584
epsin 2 isoform b; eps15 binding protein. [refseq;acc:nm_014964]	1794	5948.26	6342.84	1.06634

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.