Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Filtered Interaction Map red green network_comparison
Results: HTML CSV LaTeX Showing element 701 to 750 of 3730 in total
Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Rank
description
Filtered
red
green
network_comparison
351 melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] 0 48 51 1.0625
synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296] 1 17396.9 20483.9 1.17745
352 bet3 homolog. [swissprot;acc:o43617]
melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] 0 48 51 1.0625
353 melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]
p66 alpha. [refseq;acc:nm_017660] 1 12839 10911.1 1.17669
354 hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] 0 48 51 1.0625
transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699] 1 12839 10911.1 1.17669
355 melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 0 48 51 1.0625
tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735] 1 12839 10911.1 1.17669
356 melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 0 48 51 1.0625
t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987] 1 11004.2 12944.2 1.1763
357 imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549] 5061.11 5950.22 1.17567
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 0 48 51 1.0625
358 melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378] 1 5061.11 5950.22 1.17567
359 cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526] 12798.9 10887.2 1.17559
melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] 0 48 51 1.0625
360 g2/mitotic-specific cyclin b2. [swissprot;acc:o95067] 1 12796.8 10886 1.17553
melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] 0 48 51 1.0625
361 cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [swissprot;acc:p24941] 1 12787.6 10880.5 1.17528
melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] 0 48 51 1.0625
362 g2/mitotic-specific cyclin b1. [swissprot;acc:p14635] 1 12786.6 10879.9 1.17525
melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365] 0 48 51 1.0625
363 cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [swissprot;acc:p06493] 1 12780.7 10876.4 1.17509
melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355] 0 48 51 1.0625
364 melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]
ptb domain adaptor protein ced-6; engulfment adapter protein. [refseq;acc:nm_016315] 1 5189 6088.47 1.17334
365 calcyphosine. [swissprot;acc:q13938]
melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366] 0 48 51 1.0625
366 crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0] 1 5189 6088.47 1.17334
melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1] 0 48 51 1.0625
367 dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864] 1 4024.4 4719.35 1.17268
e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409] 0 2039.47 2164.92 1.06151
368 galectin-4 (lactose-binding lectin 4) (l-36 lactose binding protein) (l36lbp) (antigen ny-co-27). [swissprot;acc:p56470] 5946.96 5606.29 1.06077
pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508] 1 5082.66 5959.99 1.17261
369 ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701] 3583.56 4194.95 1.17061
dna directed rna polymerase ii polypeptide j-related gene isoform 1; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_145325] 0 1048.65 988.882 1.06044
370 dna directed rna polymerase ii polypeptide j-related gene isoform 3; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_032959] 1049.21 989.438 1.06041
lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455] 1 4108.15 4808.93 1.17058
371 phospholipid scramblase 3 (pl scramblase 3) (ca(2+)-dependent phospholipid scramblase 3). [swissprot;acc:q9nry6] 0 1631.97 1542.23 1.05819
serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464] 1 5067.02 5926.46 1.16961
372 coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606] 0 5427.25 5130.58 1.05782
probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105] 1 5067 5926.17 1.16956
373 kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [swissprot;acc:q16719] 0 2713.5 2864.68 1.05571
probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110] 1 5066.99 5926.1 1.16955
374 adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741] 0 2323.8 2452.23 1.05527
serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743] 1 5066.93 5925.38 1.16942
375 estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061] 0 2323.8 2452.23 1.05527
u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116] 1 4700.42 5492.63 1.16854

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/