Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Rank description Network Comparison Type Value Type Interaction Map green Filtered red network_comparison
Results: HTML CSV LaTeX Showing element 601 to 650 of 7460 in total
Value Type  : Measured
Interaction Map  : High confidence
Rank
description
Network Comparison Type
green
Filtered
red
network_comparison
151 pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989] Subtracted 13050.3 1 14830.5 1780.2
sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] Divided 5939.91 4578.09 1.29746
trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317] Subtracted 1718.6 0 1498.17 220.43
udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795] Divided 1729.7 2230.13 1.28932
152 high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339] Subtracted 6895.98 1 5136.78 1759.2
melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] Divided 18263 23693.7 1.29736
similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9] Subtracted 2179.77 0 1961.09 218.68
udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310] Divided 1729.7 2230.13 1.28932
153 block 23. [sptrembl;acc:q8nhw5] Subtracted 2159.55 1943.32 216.23
hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703] Divided 18263 1 23693.7 1.29736
myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533] Subtracted 7279.6 9035 1755.4
udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133] Divided 1729.7 0 2230.13 1.28932
154 cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551] Subtracted 2015.09 2231.05 215.96
glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075] Divided 1729.7 2230.13 1.28932
melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] 18263 1 23693.7 1.29736
myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623] Subtracted 7279.6 9035 1755.4
155 arsenical pump-driving atpase (ec 3.6.3.16) (arsenite-translocating atpase) (arsenical resistance atpase) (arsenite-transporting atpase) (arsa) (asna-i). [swissprot;acc:o43681] 1376.88 0 1162.21 214.67
melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] Divided 18263 1 23693.7 1.29736
myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535] Subtracted 7279.6 9035 1755.4
udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537] Divided 1729.7 0 2230.13 1.28932
156 melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] 18263 1 23693.7 1.29736
metaxin 1. [swissprot;acc:q13505] Subtracted 723.368 0 933.395 210.027
myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2] 7279.6 1 9035 1755.4
udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [swissprot;acc:p54855] Divided 1729.7 0 2230.13 1.28932
157 hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] 18263 1 23693.7 1.29736
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 336.584 0 261.105 1.28908
myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055] Subtracted 7279.6 1 9035 1755.4
sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538] 1633 0 1843 210
158 60s ribosomal protein l9. [swissprot;acc:p32969] 1894.01 1685.44 208.57
guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388] Divided 1649.37 1283.48 1.28508
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 18263 1 23693.7 1.29736
myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882] Subtracted 7279.6 9035 1755.4
159 lipocalin-interacting membrane receptor. [refseq;acc:nm_018113] Divided 574.372 0 734.025 1.27796
mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2] Subtracted 793.818 1002.2 208.382
myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883] 7279.6 1 9035 1755.4
necdin. [swissprot;acc:q99608] Divided 18263 23693.7 1.29736
160 bystin. [swissprot;acc:q13895] Subtracted 3135.76 0 2930.88 204.88
dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430] 7279.6 1 9035 1755.4
huntingtin interacting protein c. [refseq;acc:nm_012272] Divided 1296.38 0 1653.74 1.27566
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 18263 1 23693.7 1.29736
161 glutamine synthetase (ec 6.3.1.2) (glutamate--ammonia ligase). [swissprot;acc:p15104] Subtracted 1026.18 0 1230.54 204.36
glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434] Divided 1152.06 903.767 1.27473
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 18263 1 23693.7 1.29736
myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3] Subtracted 7279.6 9035 1755.4
162 60s ribosomal protein l23 (l17). [swissprot;acc:p23131] 1956.36 0 1753.85 202.51
cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] Divided 7252.02 5734.28 1.26468
high-mobility group 20a. [refseq;acc:nm_018200] Subtracted 6893.53 1 5140.14 1753.39
melanoma antigen, family b, 6. [refseq;acc:nm_173523] Divided 18263 23693.7 1.29736
163 likely ortholog of mouse variant polyadenylation protein cstf-64. [refseq;acc:nm_015235] Subtracted 13246.6 14976.4 1729.8
melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] Divided 18263 23693.7 1.29736

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/