Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 568 to 617 of 3730 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Rank
description
Filtered
red
green
network_comparison
284 tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677] 0 14898.9 16041.6 1.0767
285 dj408b20.3 (novel protein similar to 60s acidic ribosomal protein p2 (rplp2)). [sptrembl;acc:q9h5a9] 10686 9925.58 1.07661
t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991] 1 224.647 203.242 1.10532
286 dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832] 0 12228.2 11367.3 1.07573
enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511] 1 224.633 203.251 1.1052
287 40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47] 240.758 266.079 1.10517
proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931] 0 17842.7 16590.3 1.07549
288 40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750] 1 240.758 266.078 1.10517
5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643] 0 14930.6 16053 1.07517
289 forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488] 15147.2 14091.9 1.07489
hpaii tiny fragments locus 9c. [refseq;acc:nm_022727] 1 272.781 246.892 1.10486
290 interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123] 0 15147.2 14091.9 1.07489
ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350] 1 231.969 210.064 1.10428
291 far upstream element-binding protein; far upstream element binding protein; fuse-binding protein. [refseq;acc:nm_003902] 0 10922.9 11731.8 1.07406
nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208] 1 251.679 228.037 1.10368
292 40s ribosomal protein s15a. [swissprot;acc:p39027] 241.411 266.414 1.10357
ran-binding protein 2-like 1 isoform 2; sperm membrane protein bs-63; ran-binding protein 2-like 1. [refseq;acc:nm_032260] 0 10280.5 9574.98 1.07368
293 60s ribosomal protein l23 (l17). [swissprot;acc:p23131] 1 240.782 265.717 1.10356
ran-binding protein 2-like 1 isoform 2; sperm membrane protein bs-63; ran-binding protein 2-like 1. [refseq;acc:nm_032260] 0 10287.1 9583.27 1.07344
294 brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567] 1 240.782 265.717 1.10356
transcription initiation factor tfiid 20/15 kda subunits (tafii- 20/tafii-15) (tafii20/tafii15). [swissprot;acc:q16514] 0 13981.5 13025.1 1.07343
295 multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904] 1 223.273 202.423 1.103
transcription factor-like protein morf4 (mortality factor 4) (cellular senescence-related protein 1) (sen1). [swissprot;acc:q9y690] 0 13687.7 12751.8 1.07339
296 lon protease homolog, mitochondrial precursor (ec 3.4.21.-) (lon protease-like protein) (lonp) (lonhs). [swissprot;acc:p36776] 10194.1 10941.8 1.07335
mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956] 1 241.282 266.12 1.10294
297 60s ribosomal protein l7. [swissprot;acc:p18124] 235.727 259.984 1.1029
daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959] 0 8123.75 8719 1.07327
298 40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865] 11977.8 12842.5 1.07219
calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655] 1 268.632 243.588 1.10281
299 3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8] 0 12338.7 11512.3 1.07178
calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384] 1 268.635 243.592 1.10281
300 camp-dependent protein kinase, gamma-catalytic subunit (ec 2.7.1.37) (pka c-gamma). [swissprot;acc:p22612] 0 9270.49 8650.24 1.0717
metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889] 1 150.959 166.351 1.10196
301 beta-1,4 mannosyltransferase. [refseq;acc:nm_019109] 150.982 166.372 1.10193
sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503] 0 12783 13698 1.07158
302 60s ribosomal protein l26. [swissprot;acc:q02877] 1 242.326 267.008 1.10185
guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388] 0 7386.71 6895.44 1.07125
303 60s ribosomal protein l35. [swissprot;acc:p42766] 1 242.333 266.999 1.10179
intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3] 0 11431.4 12244.1 1.07109
304 40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174] 1 242.339 266.986 1.1017
sprouty homolog 4 (spry-4). [swissprot;acc:q9c004] 0 8021.78 7496.8 1.07003
305 microtubule-interacting protein that associates with traf3; interleukin 13 receptor alpha 1-binding protein-1. [refseq;acc:nm_015650] 9431 8815 1.06988
mitochondrial ribosomal protein l2. [refseq;acc:nm_015950] 1 242.339 266.986 1.1017
306 60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914] 242.153 266.673 1.10126
williams-beuren syndrome chromosome region 14 protein (ws basic-helix- loop-helix leucine zipper protein) (ws-bhlh) (mlx interactor). [swissprot;acc:q9np71] 0 5540 5921 1.06877
307 ba271b5.1 (similar to ribosomal protein s7). [sptrembl;acc:q9h1s9] 1091 1021 1.06856
serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4] 1 242.153 266.673 1.10126
308 60s ribosomal protein l34. [swissprot;acc:p49207]
intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811] 0 11414.1 12191.8 1.06814
309 lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428] 13651 14572 1.06747

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/