MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Filtered	green	Gene	Interaction Map	Value Type	red	network_comparison	Network Comparison Type	Rank	description

Results: HTML CSV LaTeX

Showing element 551 to 600 of 29840 in total

Filtered  : 0
Interaction Map  : High confidence

green	Value Type	red	network_comparison	Network Comparison Type	Rank	description
14.3333	Measured	19.6667	1.3721	Divided	121	4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]
			5.3334	Subtracted	460
14.4058	Rooted	7.90063	1.82337	Divided	39	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]
			6.50517	Subtracted	67
14.5086		15.297	0.7884		398	basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811]
			1.05434	Divided	332
14.5738		18.4959	1.26912		115	estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]
			3.9221	Subtracted	138
14.7003		15.4361	0.7358		400	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]
			1.05005	Divided	349
14.7392		8.79142	1.67654		45	elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897]
			5.94778	Subtracted	73
14.7595		17.4452	1.18196	Divided	141	lamin b2. [swissprot;acc:q03252]
			2.6857	Subtracted	211
14.7645		15.4896	0.7251		403	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]
			1.04911	Divided	352
14.7869		17.1325	1.15863		163	zinc finger protein 232. [swissprot;acc:q9uny5]
			2.3456	Subtracted	249
14.7892		17.1341	1.15855	Divided	164	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]
			2.3449	Subtracted	250
14.7899		17.1346	1.15853	Divided	165	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]
			2.3447	Subtracted	251
14.7969		17.1395	1.15832	Divided	166	zinc finger imprinted 2. [swissprot;acc:q9nzv7]
			2.3426	Subtracted	252
15	Measured	1	14		443	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]
			15	Divided	16
15.0206	Rooted	14.6265	0.3941	Subtracted	449	cell adhesion molecule with homology to l1cam precursor; neural cell adhesion molecule; cell adhesion molecule l1-like; l1 cell adhesion molecule 2. [refseq;acc:nm_006614]
					450	neural cell adhesion molecule l1 precursor (n-cam l1) (cd171 antigen). [swissprot;acc:p32004]
					451	transcription initiation factor tfiid 31 kda subunit (tafii-31) (tafii-32) (tafii32). [swissprot;acc:q16594]
			1.02694	Divided	434	cell adhesion molecule with homology to l1cam precursor; neural cell adhesion molecule; cell adhesion molecule l1-like; l1 cell adhesion molecule 2. [refseq;acc:nm_006614]
					435	neural cell adhesion molecule l1 precursor (n-cam l1) (cd171 antigen). [swissprot;acc:p32004]
					436	transcription initiation factor tfiid 31 kda subunit (tafii-31) (tafii-32) (tafii32). [swissprot;acc:q16594]
15.1833	Squared	50.642	3.33538		65	5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643]
			35.4587	Subtracted	353
15.2103	Rooted	15.7266	0.5163		427	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]
			1.03394	Divided	398
15.2519	Squared	50.8715	3.33542		64	tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677]
			35.6196	Subtracted	352
15.3166	Rooted	11.0051	1.39177	Divided	67	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]
			4.3115	Subtracted	114
15.3244		20.0501	1.30838	Divided	100	glycine receptor alpha-3 chain precursor. [swissprot;acc:o75311]
			4.7257	Subtracted	102
15.6768		12.0669	1.29916	Divided		transketolase-like 1 (ec 2.2.1.1) (transketolase 2) (tk 2) (transketolase related protein). [swissprot;acc:p51854]
			3.6099	Subtracted	152
15.7772		17.9668	1.13878	Divided	209	protein hspc134 (protein cda04). [swissprot;acc:q9by43]
			2.1896	Subtracted	264
15.8624		18.9056	1.19185	Divided	137	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]
			3.0432	Subtracted	168
16.0484		19.3128	1.20341	Divided	131	60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268]
			3.2644	Subtracted	161

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.