MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Filtered	green	Gene	network_comparison	Value Type	Interaction Map	Network Comparison Type	Rank	red	description

Results: HTML CSV LaTeX

Showing element 551 to 600 of 38536 in total

Filtered  : 0
Network Comparison Type  : Divided

green	network_comparison	Value Type	Interaction Map	Rank	red	description
14.7595	1.18196	Rooted	High confidence	141	17.4452	lamin b2. [swissprot;acc:q03252]
14.7645	1.04911			352	15.4896	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]
14.7869	1.15863			163	17.1325	zinc finger protein 232. [swissprot;acc:q9uny5]
14.7892	1.15855			164	17.1341	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]
14.7899	1.15853			165	17.1346	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]
14.7969	1.15832			166	17.1395	zinc finger imprinted 2. [swissprot;acc:q9nzv7]
14.8361	1.31214		Low confidence	96	11.3068	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884]
14.9009	1.14024			188	16.9906	lipocalin-interacting membrane receptor. [refseq;acc:nm_018113]
14.9268	1.1225			215	16.7554	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]
15	15	Measured	High confidence	16	1	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]
15.0206	1.02694	Rooted		434	14.6265	cell adhesion molecule with homology to l1cam precursor; neural cell adhesion molecule; cell adhesion molecule l1-like; l1 cell adhesion molecule 2. [refseq;acc:nm_006614]
				435		neural cell adhesion molecule l1 precursor (n-cam l1) (cd171 antigen). [swissprot;acc:p32004]
				436		transcription initiation factor tfiid 31 kda subunit (tafii-31) (tafii-32) (tafii32). [swissprot;acc:q16594]
15.1268	1.11471		Low confidence	231	16.862	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]
15.1833	3.33538	Squared	High confidence	65	50.642	5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643]
			Low confidence	68
15.2103	1.03394	Rooted	High confidence	398	15.7266	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]
15.2519	3.33542	Squared		64	50.8715	tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677]
			Low confidence	67
15.2522	2.02764			107	30.926	dok-like protein. [refseq;acc:nm_024872]
15.3166	1.39177	Rooted	High confidence	67	11.0051	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]
15.3176	1.20627		Low confidence	130	18.4771	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]
15.3244	1.30838		High confidence	100	20.0501	glycine receptor alpha-3 chain precursor. [swissprot;acc:o75311]
15.3568	1.0952		Low confidence	369	16.8187	lamin b2. [swissprot;acc:q03252]
15.3638	2.57517	Squared		82	5.96612	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]
15.6032	1.35616	Rooted		76	11.5054	phosphatase and tensin homolog 2 (fragment). [sptrembl;acc:o43460]
15.6768	1.29916		High confidence	102	12.0669	transketolase-like 1 (ec 2.2.1.1) (transketolase 2) (tk 2) (transketolase related protein). [swissprot;acc:p51854]
15.7738	1.09728		Low confidence	365	14.3754	diacylglycerol o-acyltransferase 1 (ec 2.3.1.20) (diglyceride acyltransferase) (acat related gene product 1). [swissprot;acc:o75907]
15.7772	1.13878		High confidence	209	17.9668	protein hspc134 (protein cda04). [swissprot;acc:q9by43]
15.7864	1.05048		Low confidence	522	15.0278	nanos (fragment). [sptrembl;acc:q8wy41]
15.8624	1.19185		High confidence	137	18.9056	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]
16.0229	1.02871		Low confidence	640	16.4829	glycine dehydrogenase [decarboxylating], mitochondrial precursor (ec 1.4.4.2) (glycine decarboxylase) (glycine cleavage system p- protein). [swissprot;acc:p23378]
16.0484	1.20341		High confidence	131	19.3128	60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268]
16.0998	1.144		Low confidence	181	14.0733	bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]
16.107	1.16163			163	18.7104	guanine nucleotide-binding protein g(s), alpha subunit (adenylate cyclase-stimulating g alpha protein). [swissprot;acc:p04895]
16.1491	1.37427		High confidence	71	22.1933	transducin beta-like 2 protein (ws beta-transducin repeats protein) (ws-betatrp) (williams-beuren syndrome chromosome region 13 protein). [swissprot;acc:q9y4p3]
			Low confidence	72
16.1728	1.07205			435	15.0859	potential phospholipid-transporting atpase vc (ec 3.6.3.1) (atpvc) (aminophospholipid translocase vc). [swissprot;acc:o60312]
16.2053	1.02286			678	15.8432	solute carrier family 4, sodium bicarbonate cotransporter, member 8. [refseq;acc:nm_004858]
16.2533	1.06821			448	15.2155	small nuclear ribonucleoprotein associated proteins b and b' (snrnp-b) (sm protein b/b') (sm-b/sm-b') (smb/smb'). [swissprot;acc:p14678]
16.2554	1.10737			350	18.0008	rwd domain containing 1; ptd013 protein; cgi-24 protein. [refseq;acc:nm_015952]
16.281	1.50287		High confidence	55	24.4683	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]
16.3116	1.05642			329	15.4404	transcription initiation factor tfiid 20/15 kda subunits (tafii- 20/tafii-15) (tafii20/tafii15). [swissprot;acc:q16514]
16.4326	1.12541		Low confidence	213	18.4934	mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2]
16.4963	1.27619		High confidence	111	21.0524	soluble liver antigen/liver pancreas antigen. [refseq;acc:nm_153825]
			Low confidence	107
16.5084	1.06288			473	15.5317	atp-dependent dna helicase ii, 70 kda subunit (lupus ku autoantigen protein p70) (ku70) (70 kda subunit of ku antigen) (thyroid-lupus autoantigen) (tlaa) (ctc box binding factor 75 kda subunit) (ctcbf) (ctc75). [swissprot;acc:p12956]
16.5202	1.01376		High confidence	460	16.2959	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]
16.5305	1.1701			154	14.1274	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]
16.6448	1.16953			155	14.232	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.