Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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description Rank Gene Filtered Value Type Network Comparison Type Interaction Map red network_comparison green
Results: HTML CSV LaTeX Showing element 551 to 600 of 3730 in total
Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
description
Rank
Filtered
red
network_comparison
green
cab2. [refseq;acc:nm_033419] 2 0 0.00001 17400000 174
2618 1 5599.85 1.01485 5683
cad protein [includes: glutamine-dependent carbamoyl-phosphate synthase (ec 6.3.5.5); aspartate carbamoyltransferase (ec 2.1.3.2); dihydroorotase (ec 3.5.2.3)]. [swissprot;acc:p27708] 1217 6021.21 1.08557 6536.45
cadherin-related tumor suppressor homolog precursor (fat protein homolog). [swissprot;acc:q14517] 1723 5458.12 1.06827 5830.76
calcipressin 1 (down syndrome critical region protein 1) (myocyte- enriched calcineurin interacting protein 1) (mcip1) (adapt78). [swissprot;acc:p53805] 1356 5657.71 1.07881 6103.57
calcipressin 2 (thyroid hormone-responsive protein zaki-4) (down syndrome candidate region 1-like 1) (myocyte-enriched calcineurin interacting protein 2) (mcip2). [swissprot;acc:q14206] 1360 5657.72 1.07879 6103.52
calcipressin 3 (down syndrome candidate region 1-like protein 2) (myocyte-enriched calcineurin interacting protein 3) (mcip3). [swissprot;acc:q9uka8] 1361
calcium-binding mitochondrial carrier protein aralar1 (solute carrier family 25, member 12). [swissprot;acc:o75746] 1913 6858.84 1.06246 7287.27
calcium-binding mitochondrial carrier protein aralar2 (solute carrier family 25, member 13) (citrin). [swissprot;acc:q9ujs0] 1916
calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632] 440 6251.91 1.15038 7192.08
calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194] 606 6148.94 1.13121 6955.76
calcium/calmodulin-dependent protein kinase type ii alpha chain (ec 2.7.1.123) (cam-kinase ii alpha chain) (cam kinase ii alpha subunit) (camk-ii alpha subunit). [swissprot;acc:q9uqm7] 1385 6079.45 1.07829 6555.4
calcium/calmodulin-dependent protein kinase type ii beta chain (ec 2.7.1.123) (cam-kinase ii beta chain) (cam kinase ii beta subunit) (camk-ii beta subunit). [swissprot;acc:q13554] 1386 6079.46 6555.41
calcium/calmodulin-dependent protein kinase type ii delta chain (ec 2.7.1.123) (cam-kinase ii delta chain) (cam kinase ii delta subunit) (camk-ii delta subunit). [swissprot;acc:q13557] 1376
calcium/calmodulin-dependent protein kinase type ii gamma chain (ec 2.7.1.123) (cam-kinase ii gamma chain) (cam kinase ii gamma subunit) (camk-ii gamma subunit) (fragment). [swissprot;acc:q13555] 1375 6079.45 6555.4
calcyphosine. [swissprot;acc:q13938] 126 0 472.524 1.3457 635.875
365 1 5189 1.17334 6088.47
calmegin precursor. [swissprot;acc:o14967] 1473 5910.06 1.0753 6355.08
calmodulin. [swissprot;acc:p02593] 2928 0.00001 1 0.00001
calnexin precursor (major histocompatibility complex class i antigen-binding protein p88) (p90) (ip90). [swissprot;acc:p27824] 1474 5910.06 1.0753 6355.08
calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384] 2384 4164.96 1.04129 4336.92
calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655] 2383 4164.76 1.04136 4337.01
calreticulin precursor (crp55) (calregulin) (hacbp) (erp60). [swissprot;acc:p27797] 1526 5369.1 1.0735 5763.72
calsyntenin-1 precursor. [swissprot;acc:o94985] 536 10603.5 1.13826 12069.5
calsyntenin-2 precursor. [swissprot;acc:q9h4d0] 541 10600.3 1.13819 12065.2
calsyntenin-3 precursor. [swissprot;acc:q9bqt9] 543 10599.9 12064.7
camp response element-binding protein cre-bpa. [refseq;acc:nm_004904] 1439 5658.8 1.07683 6093.56
camp responsive element binding protein-like 2. [refseq;acc:nm_001310] 3078 0.00001 1 0.00001
camp-dependent protein kinase type i-alpha regulatory chain (tissue- specific extinguisher-1) (tse1). [swissprot;acc:p10644] 3089
camp-dependent protein kinase type ii-alpha regulatory chain. [swissprot;acc:p13861] 1710 5916.13 1.06857 6321.77
camp-dependent protein kinase type ii-beta regulatory chain. [swissprot;acc:p31323] 1715 5918.48 1.06849 6323.83
camp-dependent protein kinase, alpha-catalytic subunit (ec 2.7.1.37) (pka c-alpha). [swissprot;acc:p17612] 1714 5917.23 1.06853 6322.73
camp-dependent protein kinase, beta-catalytic subunit (ec 2.7.1.37) (pka c-beta). [swissprot;acc:p22694] 1713
camp-dependent protein kinase, gamma-catalytic subunit (ec 2.7.1.37) (pka c-gamma). [swissprot;acc:p22612] 381 0 2509.05 1.04972 2633.79
1712 1 5917.23 1.06853 6322.73
candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822] 2025 4813.13 1.05781 5091.36
carboxypeptidase a1 precursor (ec 3.4.17.1). [swissprot;acc:p15085] 2351 8353.97 1.04406 8001.45
carboxypeptidase a5. [refseq;acc:nm_080385] 2344
carboxypeptidase b precursor (ec 3.4.17.2) (pancreas-specific protein) (pasp). [swissprot;acc:p15086] 2345
carboxypeptidase b precursor. [refseq;acc:nm_020361] 239 7711.38 1.23071 6265.8
carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870] 316 0 525 1.09714 576
719 1 6593.17 1.117 7364.55
carboxypeptidase n catalytic chain precursor (ec 3.4.17.3) (arginine carboxypeptidase) (kininase 1) (serum carboxypeptidase n) (scpn) (anaphylatoxin inactivator) (plasma carboxypeptidase b). [swissprot;acc:p15169] 717
carcinoma related gene. [refseq;acc:nm_016041] 3179 0.00001 1 0.00001
carnitine o-acetyltransferase (ec 2.3.1.7) (carnitine acetylase) (cat). [swissprot;acc:p43155] 1093 5791.05 1.09075 6316.61
carnitine o-palmitoyltransferase ii, mitochondrial precursor (ec 2.3.1.21) (cpt ii). [swissprot;acc:p23786] 2885 0.00001 1 0.00001
cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747] 207 0 403.827 1.19069 339.154
2220 1 3936.2 1.04816 3755.33
casein kinase i alpha s-like. [refseq;acc:nm_145203] 238 0 2198.47 1.13678 1933.94
953 1 4906.33 1.09705 5382.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
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