MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Filtered	Value Type	green	Rank	network_comparison	Gene	Interaction Map	description	red	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 551 to 600 of 77072 in total

Filtered  : 0
Value Type  : Measured

green	Rank	network_comparison	Interaction Map	description	red	Network Comparison Type
378.206	147	1.29455	High confidence	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]	292.152	Divided
	307	86.054				Subtracted
379.277	55	2.17326	Low confidence	selenoprotein t. [swissprot;acc:q9nzj3]	174.52	Divided
	275	204.757				Subtracted
379.474	148	1.29435	High confidence	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]	293.178	Divided
	149			cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]
	305	86.296		cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]		Subtracted
	306			cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]
384.407	62	1.82385		dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]	210.767	Divided
	187	173.64				Subtracted
384.733	186	1.22228		glycine receptor alpha-3 chain precursor. [swissprot;acc:o75311]	470.251	Divided
	311	85.518				Subtracted
384.843	295	1.10902		adaptor-related protein complex 1, mu 2 subunit (mu-adaptin 2) (adaptor protein complex ap-1 mu-2 subunit) (golgi adaptor ha1/ap1 adaptin mu-2 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 2) (ap-mu chain family member mu1b). [swissprot;acc:q9y6q5]	426.8	Divided
	378	41.957				Subtracted
385.626	66	1.78524		soluble liver antigen/liver pancreas antigen. [refseq;acc:nm_153825]	688.436	Divided
	73		Low confidence
	104	302.81	High confidence			Subtracted
	194		Low confidence
391	128	1.32993		double-stranded rna-specific editase 1 (ec 3.5.-.-) (dsrna adenosine deaminase) (rna editing deaminase 1) (rna editing enzyme 1). [swissprot;acc:p78563]	294	Divided
	443	97				Subtracted
399.534	233	1.14538	High confidence	maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]	348.823	Divided
	360	50.711				Subtracted
402	100	1.47761		atp-dependent dna helicase ii, 70 kda subunit (lupus ku autoantigen protein p70) (ku70) (70 kda subunit of ku antigen) (thyroid-lupus autoantigen) (tlaa) (ctc box binding factor 75 kda subunit) (ctcbf) (ctc75). [swissprot;acc:p12956]	594	Divided
	171	192				Subtracted
402.138	520	1.05585	Low confidence	dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]	380.866	Divided
	735	21.272				Subtracted
403.196	48	2.15895	High confidence	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	870.482	Divided
	61	467.286				Subtracted
405.367	385	1.04615		40s ribosomal protein s28. [swissprot;acc:p25112]	387.486	Divided
	430	17.881				Subtracted
410	115	1.3561	Low confidence	g protein-coupled receptor kinase grk5 (ec 2.7.1.-) (g-protein-coupled receptor kinase 5). [swissprot;acc:p34947]	556	Divided
	116			g protein-coupled receptor kinase grk6 (ec 2.7.1.-) (g-protein-coupled receptor kinase 6). [swissprot;acc:p43250]
	335	146		g protein-coupled receptor kinase grk5 (ec 2.7.1.-) (g-protein-coupled receptor kinase 5). [swissprot;acc:p34947]		Subtracted
	336			g protein-coupled receptor kinase grk6 (ec 2.7.1.-) (g-protein-coupled receptor kinase 6). [swissprot;acc:p43250]
416.524	77	1.70956	High confidence	inosine-5'-monophosphate dehydrogenase 2 (ec 1.1.1.205) (imp dehydrogenase 2) (impdh-ii) (impd 2). [swissprot;acc:p12268]	712.071	Divided
	106	295.547				Subtracted
417.983	167	1.26047		transcription factor mafk (erythroid transcription factor nf-e2 p18 subunit). [swissprot;acc:o60675]	331.61	Divided
	303	86.373				Subtracted
420.355	168	1.2585		transcription factor mafg (v-maf musculoaponeurotic fibrosarcoma oncogene homolog g) (hmaf). [swissprot;acc:o15525]	334.012	Divided
	304	86.343				Subtracted
421	108	1.44178		basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811]	292	Divided
	245	129				Subtracted
426.641	340	1.13821	Low confidence	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	374.834	Divided
	596	51.807				Subtracted
429	477	1.00704	High confidence	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	426	Divided
	479	3				Subtracted
	791	1.00704	Low confidence			Divided
	811	3				Subtracted
430.121	145	1.28761		lipocalin-interacting membrane receptor. [refseq;acc:nm_018113]	553.827	Divided
	390	123.706				Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.