MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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green	Filtered	description	network_comparison	Gene	Value Type	Interaction Map	red	Network Comparison Type	Rank

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Showing element 551 to 600 of 77072 in total

green  : 0
Filtered  : 1
network_comparison  : 0
Interaction Map  : High confidence
red  : 0
Network Comparison Type  : Subtracted

description	Value Type	Rank
dynein intermediate chain 1, axonemal (axonemal dynein intermediate chain 1). [swissprot;acc:q9ui46]	Measured	3029
	Ranked
	Squared
	Rooted
ecotropic virus integration 1 site protein. [swissprot;acc:q03112]	Measured	3170
	Ranked
	Squared
	Rooted
ell-associated factor 2; uncharacterized bone marrow protein bm040; testosterone regulated apoptosis inducer and tumor suppressor. [refseq;acc:nm_018456]	Measured	2921
	Ranked
	Squared
	Rooted
elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897]	Measured	3027
	Ranked
	Squared
	Rooted
endosome-associated fyve-domain protein. [refseq;acc:nm_014733]	Measured	3200
	Ranked
	Squared
	Rooted
enhancer of zeste homolog 1 (enx-2). [swissprot;acc:q92800]	Measured	3090
	Ranked
	Squared
	Rooted
enhancer of zeste homolog 2 (enx-1). [swissprot;acc:q15910]	Measured	3098
	Ranked
	Squared
	Rooted
ergic-53 protein precursor (er-golgi intermediate compartment 53 kda protein) (lectin, mannose-binding 1) (gp58) (intracellular mannose specific lectin mr60). [swissprot;acc:p49257]	Measured	3177
	Ranked
	Squared
	Rooted
erythroid differentiation-related factor 1. [refseq;acc:nm_015608]	Measured	3095
	Ranked
	Squared
	Rooted
eukaryotic initiation factor 4a-i (eif-4a-i) (eif4a-i). [swissprot;acc:p04765]	Measured	2868
	Ranked
	Squared
	Rooted
eukaryotic initiation factor 4a-ii (eif-4a-ii) (eif4a-ii). [swissprot;acc:q14240]	Measured	2888
	Ranked
	Squared
	Rooted
exocyst complex component exo70. [swissprot;acc:q9upt5]	Measured	2781
	Ranked
	Squared
	Rooted
ezrin-binding partner pace-1 isoform 1. [refseq;acc:nm_020423]	Measured	3228
	Ranked

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.