MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Filtered	description	green	Value Type	Interaction Map	network_comparison	Gene	Rank	red	Network Comparison Type

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Showing element 551 to 600 of 38536 in total

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Network Comparison Type  : Divided

description	green	Value Type	Interaction Map	network_comparison	Rank	red
amiloride-sensitive cation channel 3 isoform a; testis sodium channel 1; proton-gated cation channel subunit; modulatory subunit of asic2a; amiloride-sensitive cation channel 3, testis. [refseq;acc:nm_004769]	191.025	Measured	Low confidence	1.29786	139	147.185
	12631.5	Ranked		1.02052	679	12377.5
amiloride-sensitive sodium channel delta-subunit (epithelial na+ channel delta subunit) (delta enac) (nonvoltage-gated sodium channel 1 delta subunit) (scned) (delta nach). [swissprot;acc:p51172]	12.3994	Rooted		1.05566	498	11.7456
	17.4184	Squared		2.95519	75	5.89418
	194.326	Measured		1.32901	129	146.219
	12556.6	Ranked		1.01163	749	12412.3
amiloride-sensitive sodium channel gamma-subunit (epithelial na+ channel gamma subunit) (gamma enac) (nonvoltage-gated sodium channel 1 gamma subunit) (scneg) (gamma nach). [swissprot;acc:p51170]	12.2755	Rooted		1.0411	570	11.7909
	17.0364	Squared		2.86222	78	5.95216
	191.013	Measured		1.29775	140	147.188
	12631.8	Ranked		1.02055	678	12377.4
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	35.7083	Rooted		1.00771	784	35.9836
	71.5378		High confidence	1.03816	378	74.2677
	4624.67	Measured	Low confidence	1.01185	758	4679.45
	9812.39	Ranked	High confidence	1.08171	279	10614.2
	10847.1		Low confidence	1.01831	704	10652.1
	14167	Measured	High confidence	1.08783	332	15411.3
	44134.3	Squared	Low confidence	1.06886	606	47173.2
	170319		High confidence	1.14724	329	195397
anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801]	66	Rooted	Low confidence	1.44645	64	45.6289
	1933	Ranked		1.65028	12	3190
	4356	Measured		2.09222	62	2082
	4491.06	Squared		4.37738	57	1025.97
apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	24.7479	Rooted		1.03573	598	25.6322
	55.9159		High confidence	1.03778	381	53.8801
	2283.84	Measured	Low confidence	1.02656	650	2224.76
	11582.7	Ranked	High confidence	1.02719	427	11276.1
	12125.1	Measured		1.12092	276	10817.1
	12156	Ranked	Low confidence	1.04179	578	11668.4
	17253.9	Squared		1.13698	347	15175.2
	170628		High confidence	1.2613	261	135280
aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	17.1911	Rooted	Low confidence	1.03249	616	17.7497
	17.849		High confidence	1.18172	142	21.0926
	609.23	Measured	Low confidence	1.13211	351	689.713
	933.158	Squared		1.31312	205	1225.35
	1354.26	Measured	High confidence	1.26383	164	1711.55
	6483.52	Squared		1.79304	134	11625.2
	12093	Ranked	Low confidence	1.01871	697	12319.2
	14370.7		High confidence	1.19269	118	12049
arf gtpase-activating protein. [refseq;acc:nm_133446]	0.324024	Squared	Low confidence	3.18189	70	1.03101
	6.08276	Rooted		1.33558	87	8.12404
	37	Measured		1.78378	74	66
	16969	Ranked		1.13962	268	14890
ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [swissprot;acc:o95376]	33.9829	Rooted		1.029	636	34.9685
	42.3517		High confidence	1.13858	211	48.2208
	1500.84	Squared		1.16098	324	1742.44
	2076.5	Measured		1.18661	211	2464
	4554.5	Ranked		1.38688	52	3284
	4967.68	Measured	Low confidence	1.02994	629	5116.41
	11715.9	Ranked		1.02404	652	11440.9
	57580.1	Squared		1.06518	614	61333

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.