Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Gene Filtered green Network Comparison Type Rank description Interaction Map Value Type red network_comparison
Results: HTML CSV LaTeX Showing element 501 to 550 of 38536 in total
Filtered  : 0
Network Comparison Type  : Divided
green
Rank
description
Interaction Map
Value Type
red
network_comparison
12.7411 31 synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296] Low confidence Rooted 7.3589 1.73139
12.753 120 selenoprotein t. [swissprot;acc:q9nzj3] 10.2488 1.24434
12.7728 540 mitochondrial carrier protein mgc4399. [refseq;acc:nm_032315] 12.1897 1.04784
12.8712 697 cln3 protein (battenin) (batten disease protein). [swissprot;acc:q13286] 13.1329 1.02033
12.8903 384 60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914] High confidence 13.3606 1.03648
12.9333 205 transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186] Low confidence 14.6047 1.12923
12.9538 67 alpha 2 globin. [refseq;acc:nm_000517] 18.3553 1.41698
12.9627 68 hemoglobin gamma-a and gamma-g chains. [swissprot;acc:p02096] 18.3618 1.41651
12.9659 69 myoglobin. [swissprot;acc:p02144] 18.3642 1.41635
13.034 124 f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755] High confidence 10.6611 1.22258
13.1421 390 alpha-nac protein. [sptrembl;acc:q9h009] Squared 12.1126 1.08499
13.1443 387 nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594] 12.0783 1.08826
13.1909 93 cab2. [refseq;acc:nm_033419] Rooted 0.00001 1319090
13.3054 147 cg4853 gene product. [refseq;acc:nm_145313] Low confidence 15.6248 1.17432
13.373 433 rab gdp dissociation inhibitor alpha (rab gdi alpha) (gdi-1) (xap-4) (oligophrenin 2). [swissprot;acc:p31150] High confidence 13.7373 1.02724
13.4012 760 cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946] Low confidence 13.5552 1.01149
13.448 83 mitochondrial 28s ribosomal protein s6 (mrp-s6). [swissprot;acc:p82932] Squared 34.4089 2.55866
13.4716 164 piwi-like 2; miwi like. [refseq;acc:nm_018068] Rooted 15.6118 1.15887
13.5207 69 cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747] High confidence 18.7392 1.38596
13.5494 224 protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992] Low confidence 15.1522 1.11829
13.5647 40 cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336] High confidence 24.454 1.80277
13.6105 76 testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [swissprot;acc:p16562] 10.025 1.35766
13.6518 344 espin. [refseq;acc:nm_031475] Low confidence 15.1813 1.11204
13.7156 405 poly(rc)-binding protein 2 (alpha-cp2) (hnrnp-e2). [swissprot;acc:q15366] 12.6468 1.08451
13.7907 358 estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454] 15.1752 1.10039
13.8207 218 testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [swissprot;acc:p16562] High confidence Squared 19.1247 1.38377
13.8963 394 tbp-associated factor 9l; neuronal cell death-related protein; taf9-like rna polymerase ii, tata box binding protein (tbp)-associated factor, 31 kd; neuronal cell death-related gene in neuron-7; transcription associated factor tafii31l; transcription initiation factor iid, 31kd subunit. [refseq;acc:nm_015975] Rooted 13.4343 1.03439
13.9084 143 importin 4. [refseq;acc:nm_024658] 16.4019 1.17928
13.9284 232 gaba-a receptor-associated protein. [sptrembl;acc:q9by60] 15.6205 1.12149
14.0846 121 myosin vi. [swissprot;acc:q9um54] 17.3551 1.2322
123 Low confidence
14.1963 267 transcription factor mafk (erythroid transcription factor nf-e2 p18 subunit). [swissprot;acc:o60675] High confidence 12.9585 1.09552
14.2577 268 transcription factor mafg (v-maf musculoaponeurotic fibrosarcoma oncogene homolog g) (hmaf). [swissprot;acc:o15525] 13.0249 1.09465
14.3004 195 adapter-related protein complex 1 sigma 1b subunit (sigma-adaptin 1b) (adaptor protein complex ap-1 sigma-1b subunit) (golgi adaptor ha1/ap1 adaptin sigma-1b subunit) (clathrin assembly protein complex 1 sigma- 1b small chain) (sigma 1b subunit of ap-1 clathrin) (dc22). [swissprot;acc:p56377] Low confidence 16.2358 1.13534
14.3151 246 maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168] High confidence 12.8935 1.11026
14.3181 637 dynactin 1 (150 kda dynein-associated polypeptide) (dp-150) (dap-150) (p150-glued) (p135). [swissprot;acc:q14203] Low confidence 14.7323 1.02893
14.3236 208 stromal membrane-associated protein; stromal membrane-associated protein smap1a. [refseq;acc:nm_021940] 16.162 1.12835
14.3333 121 4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404] High confidence Measured 19.6667 1.3721
14.4058 25 potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] Low confidence Rooted 7.90063 1.82337
39 High confidence
14.4887 84 dynamin-like 120 kda protein, mitochondrial precursor (optic atrophy 1 gene protein). [swissprot;acc:o60313] Low confidence 19.5973 1.35259
14.4914 159 helicase/primase complex protein. [refseq;acc:nm_138336] 16.8523 1.16292
14.5086 332 basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811] High confidence 15.297 1.05434
14.5738 115 estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454] 18.4959 1.26912
14.6565 408 glycerol kinase (ec 2.7.1.30) (atp:glycerol 3-phosphotransferase) (glycerokinase) (gk). [swissprot;acc:p32189] Low confidence 15.8382 1.08063
14.6595 410 glycerol kinase, testis specific 1 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14409] 15.829 1.07978
14.6672 419 glycerol kinase, testis specific 2 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14410] 15.8017 1.07735
14.6994 152 f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755] 17.1858 1.16915
14.7003 349 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] High confidence 15.4361 1.05005
14.7392 45 elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897] 8.79142 1.67654

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/