MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Gene	description	Rank	Value Type	Filtered	Interaction Map	Network Comparison Type	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 77072 in total

Filtered  : 1

description	Rank	Value Type	Interaction Map	Network Comparison Type	green	red	network_comparison
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	307	Measured	High confidence	Subtracted	8636.87	7556.75	1080.12
	508			Divided			1.14293
	609	Rooted		Subtracted	79.1931	74.3877	4.8054
	773	Measured	Low confidence		8587.03	8256.68	330.35
	804	Rooted	High confidence	Divided	79.1931	74.3877	1.0646
	880	Measured	Low confidence		8587.03	8256.68	1.04001
	977	Rooted		Subtracted	76.3467	73.5068	2.8399
	1032	Ranked	High confidence	Divided	180.943	186.664	1.03162
	1084	Rooted	Low confidence		76.3467	73.5068	1.03863
	1115	Ranked	High confidence	Subtracted	180.943	186.664	5.721
	1322		Low confidence	Divided	194.014	198.322	1.0222
	1406			Subtracted			4.308
	4523	Squared			45740.5	46616.1	875.6
	4569			Divided			1.01914
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	210	Measured		Subtracted	9081.29	8530.51	550.78
	237			Divided			1.06457
	280	Squared	High confidence	Subtracted	38866.5	30566.4	8300.1
	311			Divided			1.27154
	319	Measured		Subtracted	8532.02	7477	1055.02
	331	Rooted	Low confidence		79.5804	75.8843	3.6961
	378			Divided			1.04871
	514	Measured	High confidence		8532.02	7477	1.1411
	588	Ranked	Low confidence		185.859	191.507	1.03039
	631	Rooted	High confidence	Subtracted	78.5795	73.8577	4.7218
	664	Ranked	Low confidence		185.859	191.507	5.648
	822	Rooted	High confidence	Divided	78.5795	73.8577	1.06393
	1048	Ranked			182.308	187.96	1.031
	1128			Subtracted			5.652
	3936	Squared	Low confidence		47372.8	46138.2	1234.6
	4138			Divided			1.02676
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	230	Measured		Subtracted	9018.94	8492.92	526.02
	252			Divided			1.06194
	279	Squared	High confidence	Subtracted	38919.9	30596.2	8323.7
	308			Divided			1.27205
	318	Measured		Subtracted	8543.66	7485.08	1058.58
	369	Rooted	Low confidence		79.1997	75.6219	3.5778
	427			Divided			1.04731
	513	Measured	High confidence		8543.66	7485.08	1.14143
	616	Rooted		Subtracted	78.6514	73.9102	4.7412
	637	Ranked	Low confidence	Divided	186.751	192.166	1.029
	737			Subtracted			5.415
	811	Rooted	High confidence	Divided	78.6514	73.9102	1.06415
	1043	Ranked			182.137	187.834	1.03128
	1121			Subtracted			5.697
	4331	Squared	Low confidence		47088.3	46049.4	1038.9
	4418			Divided			1.02256
1-aminocyclopropane-1-carboxylate synthase. [refseq;acc:nm_032592]	1941	Measured		Subtracted	8323.04	8065.05	257.99
	2035			Divided			1.03199
	2688	Rooted		Subtracted	74.9741	72.5914	2.3827
	2766			Divided			1.03282

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.