Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Rank Gene Hugo description Value Type Network Comparison Type red Interaction Map green Filtered network_comparison
Results: HTML CSV LaTeX Showing element 51 to 100 of 3228 in total 
Value Type	Ranked
Network Comparison Type	Divided
Interaction Map	High confidence
Filtered	1

Rank	Hugo	description	red	green	network_comparison	
51	SPATA6	spermatogenesis associated 6. [source:refseq;acc:nm_019073]	133	105	1.26667	
52	AMPD2	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [source:swissprot;acc:q01433]	133	105	1.26667	
53	JUNB	transcription factor jun-b. [source:swissprot;acc:p17275]	201.144	158.868	1.26611	
54	JUND	transcription factor jun-d. [source:swissprot;acc:p17535]	200.941	158.941	1.26425	
55	PRKRAP1	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [source:refseq;acc:nm_003690]	320.927	254.434	1.26134	
56		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [source:swissprot;acc:o60262]	266.856	336.233	1.25998	
57	GNG12	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [source:swissprot;acc:q9ubi6]	266.856	336.233	1.25998	
58	GNG4	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [source:swissprot;acc:p50150]	266.863	336.191	1.25979	
59	GNG3	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [source:swissprot;acc:p29798]	266.863	336.19	1.25978	
60	GNG8	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [source:swissprot;acc:q9uk08]	266.864	336.184	1.25976	
61	GNG5	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [source:swissprot;acc:p30670]	266.864	336.182	1.25975	
62	GNG10	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [source:swissprot;acc:p50151]	266.865	336.181	1.25974	
63		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [source:swissprot;acc:q9y3k8]	266.865	336.178	1.25973	
64	GNG11	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [source:swissprot;acc:p50152]	266.868	336.159	1.25965	
65	GNAQ	guanine nucleotide-binding protein g(q), alpha subunit. [source:swissprot;acc:p50148]	267.136	336.077	1.25807	
66	GNA11	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [source:swissprot;acc:p29992]	267.136	336.077	1.25807	
67	GNAT2	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [source:swissprot;acc:p19087]	267.14	336.075	1.25805	
68	GNAZ	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [source:swissprot;acc:p19086]	267.139	336.075	1.25805	
69	GNAT1	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [source:swissprot;acc:p11488]	267.14	336.075	1.25805	
70	GNAI2	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [source:swissprot;acc:p04899]	267.142	336.074	1.25804	
71	GNAI1	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [source:swissprot;acc:p04898]	267.144	336.073	1.25802	
72	GNAI3	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [source:swissprot;acc:p08754]	267.144	336.073	1.25802	
73	JPH3	junctophilin 3 (junctophilin type 3) (jp-3). [source:swissprot;acc:q8wxh2]	288	362	1.25694	
74	JPH2	junctophilin 2 (junctophilin type 2) (jp-2). [source:swissprot;acc:q9br39]	288	362	1.25694	
75	SMPD2	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [source:swissprot;acc:o60906]	288	362	1.25694	
76	TMEM33	db83 protein. [source:swissprot;acc:p57088]	288	362	1.25694	
77	CACNG2	voltage-dependent calcium channel gamma-2 subunit (neuronal voltage- gated calcium channel gamma-2 subunit). [source:swissprot;acc:q9y698]	254.692	202.668	1.2567	
78	CACNG8	voltage-dependent calcium channel gamma-8 subunit (neuronal voltage- gated calcium channel gamma-8 subunit). [source:swissprot;acc:q8wxs5]	254.693	202.668	1.2567	
79	CACNG3	voltage-dependent calcium channel gamma-3 subunit (neuronal voltage- gated calcium channel gamma-3 subunit). [source:swissprot;acc:o60359]	254.693	202.668	1.2567	
80	CACNG4	voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [source:swissprot;acc:q9ubn1]	254.691	202.668	1.25669	
81	CACNG5	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [source:swissprot;acc:q9uf02]	254.614	202.646	1.25645	
82	GNB5	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [source:swissprot;acc:o14775]	267.636	335.359	1.25304	
83	MAGED4	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [source:refseq;acc:nm_030801]	88.2482	110.265	1.24949	
84	MAGEE2	hepatocellular carcinoma-associated protein hca3. [source:refseq;acc:nm_138703]	88.2482	110.265	1.24949	
85		melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [source:swissprot;acc:p43357]	88.2482	110.265	1.24949	
86	MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [source:swissprot;acc:p43364]	88.2482	110.265	1.24949	
87	MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [source:swissprot;acc:p43356]	88.2482	110.265	1.24949	
88		hepatocellular carcinoma-associated protein hca1. [source:refseq;acc:nm_020932]	88.2482	110.265	1.24949	
89	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [source:swissprot;acc:p43360]	88.2482	110.265	1.24949	
90	NDN	necdin. [source:swissprot;acc:q99608]	88.2482	110.265	1.24949	
91	MAGED1	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [source:swissprot;acc:q9y5v3]	88.2482	110.265	1.24949	
92	MAGEF1	melanoma-associated antigen f1 (mage-f1 antigen). [source:swissprot;acc:q9hay2]	88.2482	110.265	1.24949	
93	MAGEB6B	melanoma antigen, family b, 6. [source:refseq;acc:nm_173523]	88.2482	110.265	1.24949	
94		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [source:swissprot;acc:p43358]	88.2482	110.265	1.24949	
95	MAGEA9	melanoma-associated antigen 9 (mage-9 antigen). [source:swissprot;acc:p43362]	88.2482	110.265	1.24949	
96	MAGEA8	melanoma-associated antigen 8 (mage-8 antigen). [source:swissprot;acc:p43361]	88.2482	110.265	1.24949	
97	MAGEC1	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [source:swissprot;acc:o60732]	88.2482	110.265	1.24949	
98	MAGEA4	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [source:swissprot;acc:p43365]	88.2482	110.265	1.24949	
99		melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [source:swissprot;acc:p43355]	88.2482	110.265	1.24949	
100	MAGEA10	melanoma-associated antigen 10 (mage-10 antigen). [source:swissprot;acc:p43363]	88.2482	110.265	1.24949	

Legend:
- Rank is the rank after comparing the two networks
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/