MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Rank	description	Gene	Network Comparison Type	Filtered	Value Type	Interaction Map	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 301 to 350 of 3730 in total

Network Comparison Type  : Divided
Value Type  : Measured
Interaction Map  : High confidence

Rank	description	Filtered	green	red	network_comparison
151	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	1	5939.91	4578.09	1.29746
	udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795]	0	1729.7	2230.13	1.28932
152	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	1	18263	23693.7	1.29736
	udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310]	0	1729.7	2230.13	1.28932
153	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	1	18263	23693.7	1.29736
	udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133]	0	1729.7	2230.13	1.28932
154	glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075]
	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	1	18263	23693.7	1.29736
155	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]
	udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537]	0	1729.7	2230.13	1.28932
156	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	1	18263	23693.7	1.29736
	udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [swissprot;acc:p54855]	0	1729.7	2230.13	1.28932
157	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	1	18263	23693.7	1.29736
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	0	336.584	261.105	1.28908
158	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]		1649.37	1283.48	1.28508
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	1	18263	23693.7	1.29736
159	lipocalin-interacting membrane receptor. [refseq;acc:nm_018113]	0	574.372	734.025	1.27796
	necdin. [swissprot;acc:q99608]	1	18263	23693.7	1.29736
160	huntingtin interacting protein c. [refseq;acc:nm_012272]	0	1296.38	1653.74	1.27566
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	1	18263	23693.7	1.29736
161	glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434]	0	1152.06	903.767	1.27473
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	1	18263	23693.7	1.29736
162	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	0	7252.02	5734.28	1.26468
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	1	18263	23693.7	1.29736
163	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	0	6193.07	7830.62	1.26442
164	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]		1354.26	1711.55	1.26383
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	1	18263	23693.7	1.29736
165	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]
	mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2]	0	793.818	1002.2	1.26251
166	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]		7099.51	5629.62	1.2611
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	1	18263	23693.7	1.29736
167	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]
	transcription factor mafk (erythroid transcription factor nf-e2 p18 subunit). [swissprot;acc:o60675]	0	417.983	331.61	1.26047
168	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	1	18263	23693.7	1.29736
	transcription factor mafg (v-maf musculoaponeurotic fibrosarcoma oncogene homolog g) (hmaf). [swissprot;acc:o15525]	0	420.355	334.012	1.2585
169	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]		194	244	1.25773
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	1	18263	23693.7	1.29736
170	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]
	williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645]	0	141.702	112.666	1.25772
171	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	1	18263	23693.7	1.29736
	williams beuren syndrome critical region 20a isoform 2; nol1/nop2/sun gene family member; williams-beuren syndrome critical region protein 20 copy a; williams beuren syndrome chromosome region 20. [refseq;acc:nm_018044]	0	141.702	112.666	1.25772
172	trophinin. [swissprot;acc:q12816]	1	18263	23693.7	1.29736
	williams beuren syndrome chromosome region 20c isoform 1. [refseq;acc:nm_032158]	0	141.702	112.666	1.25772
173	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	1	5940.64	4579.34	1.29727
	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	0	4102.97	3265.25	1.25656
174	dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2]		612.604	488.43	1.25423
	mad protein (max dimerizer). [swissprot;acc:q05195]	1	5774.03	4455.95	1.2958
175	cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247]	0	1107	1382.5	1.24887
	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	1	5773.77	4456.67	1.29553

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.