MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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description	Rank	Gene	Value Type	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

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Showing element 151 to 200 of 3730 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence

description	Rank	Filtered	red	green	network_comparison
60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	306	1	242.153	266.673	1.10126
	429	0	12318.7	12631.5	1.02539
60s ribosomal protein l15. [swissprot;acc:p39030]	188		11745.2	13203.1	1.12413
	604	1	217.862	230.978	1.0602
60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	277	0	11096.8	10251.6	1.08245
	281	1	241.808	267.335	1.10557
60s ribosomal protein l18. [swissprot;acc:q07020]	485		237.109	254.667	1.07405
60s ribosomal protein l18a. [swissprot;acc:q02543]	102	0	12738.7	10437.1	1.22052
	860	1	234.025	224.958	1.04031
60s ribosomal protein l19. [swissprot;acc:p14118]	319		240.73	264.729	1.09969
60s ribosomal protein l21. [swissprot;acc:p46778]	41	0	9994.33	6758.83	1.47871
	1054	1	223.958	217.263	1.03082
60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268]	411	0	12115.7	12508.3	1.0324
	2205	1	199.129	200.413	1.00645
60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	293		240.782	265.717	1.10356
	311	0	10253.5	9622.45	1.06558
60s ribosomal protein l23a. [swissprot;acc:p29316]	205		11844.9	10636.3	1.11363
	323	1	241.884	265.945	1.09947
60s ribosomal protein l24 (l30). [swissprot;acc:p38663]	1767		201.288	198.86	1.01221
60s ribosomal protein l26. [swissprot;acc:q02877]	302		242.326	267.008	1.10185
60s ribosomal protein l28. [swissprot;acc:p46779]	1882		215.896	213.61	1.0107
60s ribosomal protein l29 (cell surface heparin binding protein hip). [swissprot;acc:p47914]	2664		204.768	204.549	1.00107
60s ribosomal protein l3-like. [swissprot;acc:q92901]	312		242.195	266.663	1.10103
60s ribosomal protein l30. [swissprot;acc:p04645]	378		242.593	265.365	1.09387
60s ribosomal protein l31. [swissprot;acc:p12947]	862		234.025	224.958	1.04031
60s ribosomal protein l32. [swissprot;acc:p02433]	276		241.13	266.969	1.10716
60s ribosomal protein l34, mitochondrial precursor (l34mt). [swissprot;acc:q9bq48]	1333		220.681	215.78	1.02271
60s ribosomal protein l34. [swissprot;acc:p49207]	308		242.153	266.673	1.10126
60s ribosomal protein l35. [swissprot;acc:p42766]	303		242.333	266.999	1.10179
60s ribosomal protein l36, mitochondrial precursor (l36mt) (brca1- interacting protein 1). [swissprot;acc:q9p0j6]	365		242.744	266.07	1.09609
60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	635		228.639	242.258	1.05957
60s ribosomal protein l37a. [swissprot;acc:p12751]	46	0	12941.7	18499.2	1.42943
	2959	1	0.00001	0.00001	1
60s ribosomal protein l39. [swissprot;acc:p02404]	128	0	11564.4	9794.29	1.18073
	859	1	234.025	224.958	1.04031
60s ribosomal protein l4 (l1). [swissprot;acc:p36578]	359		239.277	262.434	1.09678
60s ribosomal protein l5. [swissprot;acc:p46777]	326		241.899	265.924	1.09932
60s ribosomal protein l7. [swissprot;acc:p18124]	147	0	11080.3	9505.89	1.16562
	297	1	235.727	259.984	1.1029
60s ribosomal protein l8. [swissprot;acc:p25120]	834		231.734	222.222	1.0428
60s ribosomal protein l9. [swissprot;acc:p32969]	276	0	10741.6	9922.33	1.08257
	341	1	240.243	263.798	1.09805
65 kda yes-associated protein (yap65). [swissprot;acc:p46937]	1986		219.26	217.193	1.00952
69 kda islet cell autoantigen (ica69) (islet cell autoantigen 1) (islet cell autoantigen p69) (icap69). [swissprot;acc:q05084]	3227		0.00001	0.00001	1
9 kda protein. [swissprot;acc:p13994]	1988		219.26	217.193	1.00952
a kindred of iglon. [refseq;acc:nm_173808]	804		212.386	221.785	1.04425
a-kinase anchor protein 5 (a-kinase anchor protein 79 kda) (akap 79) (camp-dependent protein kinase regulatory subunit ii high affinity binding protein) (h21). [swissprot;acc:p24588]	2788		0.00001	0.00001	1
a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	957		129.913	134.399	1.03453
aarf domain containing kinase 1. [refseq;acc:nm_020421]	1733		215.336	212.567	1.01303
aarf domain containing kinase 2; putative ubiquinone biosynthesis protein aarf. [refseq;acc:nm_052853]	1731

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.