MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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description	Gene	Rank	Value Type	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

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Showing element 151 to 200 of 3730 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence

description	Rank	Filtered	red	green	network_comparison
60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	392	0	229.211	219.891	1.04238
	2074	1	3614.91	3423.89	1.05579
60s ribosomal protein l15. [swissprot;acc:p39030]	272	0	846.216	753.793	1.12261
	2532	1	4888.72	5006.1	1.02401
60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	232	0	1663.73	1906.28	1.14579
	1894	1	3598.08	3384.59	1.06308
60s ribosomal protein l18. [swissprot;acc:q07020]	2694		4113.79	4095.53	1.00446
60s ribosomal protein l18a. [swissprot;acc:q02543]	419	0	2688.7	2604.71	1.03225
	806	1	4708.61	5226.71	1.11003
60s ribosomal protein l19. [swissprot;acc:p14118]	2136		3687.49	3499.2	1.05381
60s ribosomal protein l21. [swissprot;acc:p46778]	72	0	572	992.083	1.73441
	1510	1	5546.11	5957.99	1.07426
60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268]	97	0	728.65	476.619	1.52879
	2673	1	7780.98	7741.14	1.00515
60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	284	0	1753.85	1956.36	1.11547
	2115	1	3672.49	3482.34	1.0546
60s ribosomal protein l23a. [swissprot;acc:p29316]	259	0	1295.49	1463.51	1.1297
	2175	1	3642.13	3463.88	1.05146
60s ribosomal protein l24 (l30). [swissprot;acc:p38663]	727		7087.23	7911.25	1.11627
60s ribosomal protein l26. [swissprot;acc:q02877]	2051		3601.97	3409.48	1.05646
60s ribosomal protein l28. [swissprot;acc:p46779]	1548		5987.29	6423.52	1.07286
60s ribosomal protein l29 (cell surface heparin binding protein hip). [swissprot;acc:p47914]	1648		6079.19	6503.12	1.06973
60s ribosomal protein l3-like. [swissprot;acc:q92901]	2114		3617.81	3430.31	1.05466
60s ribosomal protein l30. [swissprot;acc:p04645]	2386		3674.02	3529.35	1.04099
60s ribosomal protein l31. [swissprot;acc:p12947]	808		4708.61	5226.71	1.11003
60s ribosomal protein l32. [swissprot;acc:p02433]	1798		3618.02	3394.29	1.06591
60s ribosomal protein l34, mitochondrial precursor (l34mt). [swissprot;acc:q9bq48]	1300		5589.33	6047.9	1.08204
60s ribosomal protein l34. [swissprot;acc:p49207]	2077		3614.91	3423.89	1.05579
60s ribosomal protein l35. [swissprot;acc:p42766]	2065		3602.25	3410.23	1.05631
60s ribosomal protein l36, mitochondrial precursor (l36mt) (brca1- interacting protein 1). [swissprot;acc:q9p0j6]	2264		3633.74	3473.68	1.04608
60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	2548		4725.79	4824.4	1.02087
60s ribosomal protein l37a. [swissprot;acc:p12751]	18	0	305.45	26.1599	11.6763
	2959	1	0.00001	0.00001	1
60s ribosomal protein l39. [swissprot;acc:p02404]	412	0	3024.78	2923.92	1.03449
	805	1	4708.61	5226.71	1.11003
60s ribosomal protein l4 (l1). [swissprot;acc:p36578]	2360		3843.06	3682.72	1.04354
60s ribosomal protein l5. [swissprot;acc:p46777]	2169		3639.65	3459.64	1.05203
60s ribosomal protein l7. [swissprot;acc:p18124]	224	0	1915.27	2206.07	1.15183
	2308	1	3976.92	3804.85	1.04522
60s ribosomal protein l8. [swissprot;acc:p25120]	386		4533.74	5279.4	1.16447
60s ribosomal protein l9. [swissprot;acc:p32969]	265	0	1685.44	1894.01	1.12375
	2225	1	3750.99	3580.35	1.04766
65 kda yes-associated protein (yap65). [swissprot;acc:p46937]	1459		5672.25	6104.01	1.07612
69 kda islet cell autoantigen (ica69) (islet cell autoantigen 1) (islet cell autoantigen p69) (icap69). [swissprot;acc:q05084]	3227		0.00001	0.00001	1
9 kda protein. [swissprot;acc:p13994]	1461		5672.25	6104.01	1.07612
a kindred of iglon. [refseq;acc:nm_173808]	2712		5603.24	5583.64	1.00351
a-kinase anchor protein 5 (a-kinase anchor protein 79 kda) (akap 79) (camp-dependent protein kinase regulatory subunit ii high affinity binding protein) (h21). [swissprot;acc:p24588]	2788		0.00001	0.00001	1
a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	192		17757.5	14008	1.26767
aarf domain containing kinase 1. [refseq;acc:nm_020421]	1177		5799.35	6305.95	1.08735
aarf domain containing kinase 2; putative ubiquinone biosynthesis protein aarf. [refseq;acc:nm_052853]	1175

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.