Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1101 to 1150 of 8289 in total
Value Type  : Measured
Network Comparison Type  : Divided
Filtered  : 1
Rank
description
Interaction Map
red
green
network_comparison
551 repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273] High confidence 5773.45 6563.69 1.13687
sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772] Low confidence 7739.76 8100.23 1.04657
552 cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240] High confidence 15427.2 13572.8 1.13663
sterol regulatory element binding protein-1 (srebp-1) (sterol regulatory element-binding transcription factor 1). [swissprot;acc:p36956] Low confidence 7739.76 8100.23 1.04657
553 exocyst complex component sec6. [swissprot;acc:o60645] 8385.7 8776.09 1.04655
tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886] High confidence 3853.64 4379.71 1.13651
554 axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645] Low confidence 7296.43 7635.83 1.04652
pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989] High confidence 14830.5 13050.3 1.13641
555 peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936] Low confidence 7305.56 7644.68 1.04642
selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611] High confidence 6167.93 7007.7 1.13615
556 flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]
wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516] Low confidence 8139.29 8517.13 1.04642
557 inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866] High confidence 6167.93 7007.7 1.13615
single-minded homolog 1. [swissprot;acc:p81133] Low confidence 7305.56 7644.68 1.04642
558 cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2] 8130.02 8507.23 1.0464
selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903] High confidence 6167.93 7007.7 1.13615
559 inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]
son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889] Low confidence 8069.31 8443.5 1.04637
560 amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433] 7980.85 8350.82 1.04636
cystathionine beta-synthase (ec 4.2.1.22) (serine sulfhydrase) (beta-thionase). [swissprot;acc:p35520] High confidence 5480.24 6222.04 1.13536
561 lifeguard; kiaa0950 protein. [refseq;acc:nm_012306] Low confidence 7755.77 8115.27 1.04635
transforming protein rhoc (h9). [swissprot;acc:p08134] High confidence 5480.24 6222.04 1.13536
562 conserved oligomeric golgi complex component 3 (vesicle docking protein sec34 homolog) (p94). [swissprot;acc:q96jb2] Low confidence 7561.22 7911.04 1.04627
thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762] High confidence 5480.24 6222.04 1.13536
563 3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]
cytochrome p450 4f3 (ec 1.14.13.30) (cypivf3) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:q08477] Low confidence 8126.42 8502.33 1.04626
564 cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329] 8125.5 8501.28 1.04625
transforming protein rhoa (h12). [swissprot;acc:p06749] High confidence 5480.24 6222.04 1.13536
565 cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6] Low confidence 8126.71 8502.61 1.04625
small glutamine-rich tetratricopeptide repeat-containing protein (vpu-binding protein) (ubp). [swissprot;acc:o43765] High confidence 10434.4 11846.2 1.1353
566 autoantigen ngp-1. [swissprot;acc:q13823] 3766.14 4274.79 1.13506
son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890] Low confidence 8069.04 8442.25 1.04625
567 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316] High confidence 10264.9 9043.51 1.13506
ubiquitin-conjugating enzyme e2-32 kda complementing (ec 6.3.2.19) (ubiquitin-protein ligase) (ubiquitin carrier protein) (e2-cdc34). [swissprot;acc:p49427] Low confidence 7691.01 8046.06 1.04616
568 grpe protein homolog 2, mitochondrial precursor (mt-grpe#2). [swissprot;acc:q8taa5] High confidence 4134.77 4691.24 1.13458
similar to cdna sequence bc023845. [sptrembl;acc:q86xc2] Low confidence 8037.33 8408.12 1.04613
569 grpe protein homolog 1, mitochondrial precursor (mt-grpe#1) (hmge). [swissprot;acc:q9hav7] High confidence 4134.77 4691.24 1.13458
mitochondrial import inner membrane translocase subunit tim23. [swissprot;acc:o14925] Low confidence 7046.26 7370.85 1.04607
570 galectin-9 (hom-hd-21) (ecalectin). [swissprot;acc:o00182] 7997.15 8364.68 1.04596
swi/snf-related matrix-associated actin-dependent regulator of chromatin d2; rsc6p; mammalian chromatin remodeling complex brg1-associated factor 60b; swp73-like protein; chromatin remodeling complex baf60b subunit; swi/snf complex 60 kda subunit b. [refseq;acc:nm_003077] High confidence 4134.77 4691.24 1.13458
571 swi/snf-related matrix-associated actin-dependent regulator of chromatin d3; rsc6p; mammalian chromatin remodeling complex brg1-associated factor 60c; swp73-like protein; chromatin remodeling complex baf60c subunit; swi/snf complex 60 kda subunit c. [refseq;acc:nm_003078]
thimet oligopeptidase (ec 3.4.24.15) (endopeptidase 24.15) (mp78). [swissprot;acc:p52888] Low confidence 8651.4 9048.97 1.04595
572 neurolysin, mitochondrial precursor (ec 3.4.24.16) (neurotensin endopeptidase) (mitochondrial oligopeptidase m) (microsomal endopeptidase) (mep). [swissprot;acc:q9byt8]
swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily d member 1 (swi/snf complex 60 kda subunit) (brg1- associated factor 60a). [swissprot;acc:q96gm5] High confidence 4134.77 4691.24 1.13458
573 calcium-binding mitochondrial carrier protein aralar2 (solute carrier family 25, member 13) (citrin). [swissprot;acc:q9ujs0] Low confidence 8506.87 8897.23 1.04589
homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260] High confidence 6739.43 7644.55 1.1343
574 homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482] 6739.61 7644.58 1.13428
mouse mammary turmor virus receptor homolog 1. [refseq;acc:nm_152832] Low confidence 6869.53 7184.61 1.04587
575 14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946] 8572.9 8965.49 1.04579
homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269] High confidence 6739.63 7644.59 1.13427

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/