Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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description Rank Gene Value Type Network Comparison Type Interaction Map Filtered red network_comparison green
Results: HTML CSV LaTeX Showing element 101 to 150 of 3228 in total
Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
description
Rank
red
network_comparison
green
5-aminolevulinic acid synthase, erythroid-specific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-e). [swissprot;acc:p22557] 1910 6858.84 1.06246 7287.27
5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-h). [swissprot;acc:p13196] 1915
5-formyltetrahydrofolate cyclo-ligase (ec 6.3.3.2) (5,10-methenyl- tetrahydrofolate synthetase) (methenyl-thf synthetase) (mthfs). [swissprot;acc:p49914] 1833 6175.23 1.06439 6572.85
5-methyltetrahydrofolate--homocysteine methyltransferase (ec 2.1.1.13) (methionine synthase, vitamin-b12 dependent) (ms). [swissprot;acc:q99707] 1115 5795.13 1.08957 6314.19
54 kda nuclear rna- and dna-binding protein (p54(nrb)) (p54nrb) (55 kda nuclear protein) (nmt55) (non-pou domain-containing octamer- binding protein) (dna-binding p52/p100 complex, 52 kda subunit). [swissprot;acc:q15233] 2028 10243.4 1.05746 9686.82
6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [swissprot;acc:p17858] 764 4250.18 1.11269 4729.12
6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [swissprot;acc:p08237] 763 4250.54 1.11272 4729.67
6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [swissprot;acc:q01813] 759 4254.62 1.11315 4736.03
6-phosphogluconate dehydrogenase, decarboxylating (ec 1.1.1.44). [swissprot;acc:p52209] 1339 5988.06 1.07964 6464.94
6-phosphogluconolactonase (ec 3.1.1.31) (6pgl). [swissprot;acc:o95336] 1627 6038.46 1.07046 6463.9
6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [swissprot;acc:q03393] 2904 0.00001 1 0.00001
60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [swissprot;acc:p10809] 1313 5457.14 1.08112 5899.85
60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993] 1751 6011.57 1.06711 6414.98
60s acidic ribosomal protein p0 (l10e). [swissprot;acc:p05388] 2258 5150.31 1.04616 5388.05
60s acidic ribosomal protein p1. [swissprot;acc:p05386] 2418 4857.03 1.03763 5039.78
60s acidic ribosomal protein p2. [swissprot;acc:p05387] 2743 4824.49 1.0022 4813.92
60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635] 2233 3614.08 1.04754 3450.07
60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025] 2255 3624.59 1.04655 3463.37
60s ribosomal protein l11, mitochondrial precursor (l11mt) (cgi-113). [swissprot;acc:q9y3b7] 2417 3598.55 1.03775 3467.65
60s ribosomal protein l11. [swissprot;acc:p39026] 1834 3593.24 1.06437 3375.93
60s ribosomal protein l12 like protein. [sptrembl;acc:o60886] 2186 3586.3 1.05035 3414.4
60s ribosomal protein l12, mitochondrial precursor (l12mt) (5c5-2). [swissprot;acc:p52815] 2372 3677.53 1.04278 3526.65
60s ribosomal protein l12. [swissprot;acc:p30050] 2185 3586.32 1.05035 3414.42
60s ribosomal protein l13, mitochondrial (l13mt). [swissprot;acc:q9byd1] 2447 3730.53 1.03309 3611.05
60s ribosomal protein l13a (23 kda highly basic protein). [swissprot;acc:p40429] 2449 3730.74 1.03303 3611.45
60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914] 2074 3614.91 1.05579 3423.89
60s ribosomal protein l15. [swissprot;acc:p39030] 2532 4888.72 1.02401 5006.1
60s ribosomal protein l17 (l23). [swissprot;acc:p18621] 1894 3598.08 1.06308 3384.59
60s ribosomal protein l18. [swissprot;acc:q07020] 2694 4113.79 1.00446 4095.53
60s ribosomal protein l18a. [swissprot;acc:q02543] 806 4708.61 1.11003 5226.71
60s ribosomal protein l19. [swissprot;acc:p14118] 2136 3687.49 1.05381 3499.2
60s ribosomal protein l21. [swissprot;acc:p46778] 1510 5546.11 1.07426 5957.99
60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268] 2673 7780.98 1.00515 7741.14
60s ribosomal protein l23 (l17). [swissprot;acc:p23131] 2115 3672.49 1.0546 3482.34
60s ribosomal protein l23a. [swissprot;acc:p29316] 2175 3642.13 1.05146 3463.88
60s ribosomal protein l24 (l30). [swissprot;acc:p38663] 727 7087.23 1.11627 7911.25
60s ribosomal protein l26. [swissprot;acc:q02877] 2051 3601.97 1.05646 3409.48
60s ribosomal protein l28. [swissprot;acc:p46779] 1548 5987.29 1.07286 6423.52
60s ribosomal protein l29 (cell surface heparin binding protein hip). [swissprot;acc:p47914] 1648 6079.19 1.06973 6503.12
60s ribosomal protein l3-like. [swissprot;acc:q92901] 2114 3617.81 1.05466 3430.31
60s ribosomal protein l30. [swissprot;acc:p04645] 2386 3674.02 1.04099 3529.35
60s ribosomal protein l31. [swissprot;acc:p12947] 808 4708.61 1.11003 5226.71
60s ribosomal protein l32. [swissprot;acc:p02433] 1798 3618.02 1.06591 3394.29
60s ribosomal protein l34, mitochondrial precursor (l34mt). [swissprot;acc:q9bq48] 1300 5589.33 1.08204 6047.9
60s ribosomal protein l34. [swissprot;acc:p49207] 2077 3614.91 1.05579 3423.89
60s ribosomal protein l35. [swissprot;acc:p42766] 2065 3602.25 1.05631 3410.23
60s ribosomal protein l36, mitochondrial precursor (l36mt) (brca1- interacting protein 1). [swissprot;acc:q9p0j6] 2264 3633.74 1.04608 3473.68
60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403] 2548 4725.79 1.02087 4824.4
60s ribosomal protein l37a. [swissprot;acc:p12751] 2959 0.00001 1 0.00001
60s ribosomal protein l39. [swissprot;acc:p02404] 805 4708.61 1.11003 5226.71

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
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