Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Filtered description green Value Type Rank Gene network_comparison Interaction Map red Network Comparison Type
Results: HTML CSV LaTeX Showing element 101 to 150 of 38536 in total
Filtered: 0
Network Comparison Type: Divided
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[source:swissprot;acc:p49241]\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent 21.5465\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent Rooted\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent 792\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.00597\vspace{3pt}}&&\parbox{\wcG}{\vspace{3pt}\noindent 21.4186\vspace{3pt}}\\\cline{2-2}\cline{4-7} &\parbox{\wcB}{\vspace{3pt}\noindent 32.9781\vspace{3pt}}&&\parbox{\wcD}{\vspace{3pt}\noindent 404\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.03159\vspace{3pt}}&\parbox{\wcF}{\vspace{3pt}\noindent High confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent 34.0198\vspace{3pt}}\\\cline{2-7} &\parbox{\wcB}{\vspace{3pt}\noindent 2069.56\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent Measured\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent 439\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.08345\vspace{3pt}}&\parbox{\wcF}{\vspace{3pt}\noindent Low confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent 1910.16\vspace{3pt}}\\\cline{2-2}\cline{4-7} &\parbox{\wcB}{\vspace{3pt}\noindent 2879.55\vspace{3pt}}&&\parbox{\wcD}{\vspace{3pt}\noindent 447\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.01735\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcF}{\vspace{3pt}\noindent High confidence\vspace{3pt}}}&\parbox{\wcG}{\vspace{3pt}\noindent 2929.51\vspace{3pt}}\\\cline{2-5}\cline{7-7} &\parbox{\wcB}{\vspace{3pt}\noindent 8550.86\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent Squared\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 473\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.01195\vspace{3pt}}&&\parbox{\wcG}{\vspace{3pt}\noindent 8653.02\vspace{3pt}}\\\cline{2-5}\cline{7-7} &\parbox{\wcB}{\vspace{3pt}\noindent 10992.4\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent Ranked\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent 331\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05644\vspace{3pt}}&&\parbox{\wcG}{\vspace{3pt}\noindent 10405.1\vspace{3pt}}\\\cline{2-2}\cline{4-7} &\parbox{\wcB}{\vspace{3pt}\noindent 13148.4\vspace{3pt}}&&\parbox{\wcD}{\vspace{3pt}\noindent 786\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.00719\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcF}{\vspace{3pt}\noindent Low confidence\vspace{3pt}}}&\parbox{\wcG}{\vspace{3pt}\noindent 13242.9\vspace{3pt}}\\\cline{2-5}\cline{7-7} &\parbox{\wcB}{\vspace{3pt}\noindent 14964.4\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent Squared\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 241\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.25308\vspace{3pt}}&&\parbox{\wcG}{\vspace{3pt}\noindent 11942.1\vspace{3pt}}\\\hline \multirow{8}{*}{\parbox{\wcA}{\vspace{3pt}\noindent 40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [source:swissprot;acc:p12750]\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent 23.34\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent Rooted\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent 258\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.10441\vspace{3pt}}&\parbox{\wcF}{\vspace{3pt}\noindent High confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent 21.1334\vspace{3pt}}\\\cline{2-2}\cline{4-7} &\parbox{\wcB}{\vspace{3pt}\noindent 24.652\vspace{3pt}}&&\parbox{\wcD}{\vspace{3pt}\noindent 424\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.07638\vspace{3pt}}&\parbox{\wcF}{\vspace{3pt}\noindent Low confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent 22.9027\vspace{3pt}}\\\cline{2-7} &\parbox{\wcB}{\vspace{3pt}\noindent 1495.22\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent Measured\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent 255\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.1346\vspace{3pt}}&\parbox{\wcF}{\vspace{3pt}\noindent High confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent 1317.84\vspace{3pt}}\\\cline{2-2}\cline{4-7} &\parbox{\wcB}{\vspace{3pt}\noindent 1653.68\vspace{3pt}}&&\parbox{\wcD}{\vspace{3pt}\noindent 416\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.09339\vspace{3pt}}&\parbox{\wcF}{\vspace{3pt}\noindent Low confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent 1512.43\vspace{3pt}}\\\cline{2-7} &\parbox{\wcB}{\vspace{3pt}\noindent 5253.37\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent Squared\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent 273\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.24367\vspace{3pt}}&\parbox{\wcF}{\vspace{3pt}\noindent High confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent 4224.07\vspace{3pt}}\\\cline{2-2}\cline{4-7} &\parbox{\wcB}{\vspace{3pt}\noindent 6012.92\vspace{3pt}}&&\parbox{\wcD}{\vspace{3pt}\noindent 315\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.16333\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcF}{\vspace{3pt}\noindent Low confidence\vspace{3pt}}}&\parbox{\wcG}{\vspace{3pt}\noindent 5168.71\vspace{3pt}}\\\cline{2-5}\cline{7-7} &\parbox{\wcB}{\vspace{3pt}\noindent 11211.6\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent Ranked\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent 444\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.0741\vspace{3pt}}&&\parbox{\wcG}{\vspace{3pt}\noindent 12042.4\vspace{3pt}}\\\cline{2-2}\cline{4-7} &\parbox{\wcB}{\vspace{3pt}\noindent 11393.9\vspace{3pt}}&&\parbox{\wcD}{\vspace{3pt}\noindent 261\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.09259\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcF}{\vspace{3pt}\noindent High confidence\vspace{3pt}}}&\parbox{\wcG}{\vspace{3pt}\noindent 12448.9\vspace{3pt}}\\\cline{1-5}\cline{7-7} \multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent 40s ribosomal protein s4, y isoform 2. [source:swissprot;acc:q8td47]\vspace{3pt}}}&\parbox{\wcB}{\vspace{3pt}\noindent 23.3445\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent Rooted\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent 257\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.10442\vspace{3pt}}&&\parbox{\wcG}{\vspace{3pt}\noindent 21.1374\vspace{3pt}}\\\cline{2-2}\cline{4-7} &\parbox{\wcB}{\vspace{3pt}\noindent 24.621\vspace{3pt}}&&\parbox{\wcD}{\vspace{3pt}\noindent 423\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.07651\vspace{3pt}}&\parbox{\wcF}{\vspace{3pt}\noindent Low confidence\vspace{3pt}}&\parbox{\wcG}{\vspace{3pt}\noindent 22.8712\vspace{3pt}}\\\hline nd{longtable}
Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/