Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Gene Rank description Value Type Interaction Map Filtered Network Comparison Type network_comparison green red
Results: HTML CSV LaTeX Showing element 101 to 150 of 16578 in total
Value Type  : Measured
Filtered  : 1
Rank
description
Interaction Map
Network Comparison Type
network_comparison
green
red
26 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6] High confidence Divided 2.0534 892.67 1833.01
hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] Subtracted 5430.7 18263 23693.7
septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599] Low confidence 1829.9 15033.4 13203.5
sperm associated antigen 7. [refseq;acc:nm_004890] Divided 1.20939 19280.8 23318
27 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150] High confidence 2.04922 895.134 1834.33
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] Subtracted 5430.7 18263 23693.7
microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8] Low confidence 1815.7 11654.4 13470.1
protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690] Divided 1.20152 4614.87 3840.85
28 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798] High confidence 2.04912 895.194 1834.36
microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492] Low confidence Subtracted 1814.4 11652.4 13466.8
necdin. [swissprot;acc:q99608] High confidence 5430.7 18263 23693.7
tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106] Low confidence Divided 1.2003 3719.66 3098.94
29 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08] High confidence 2.04858 895.507 1834.52
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] Subtracted 5430.7 18263 23693.7
septin 10 isoform 1. [refseq;acc:nm_144710] Low confidence 1791.4 14872.6 13081.2
tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616] Divided 1.19818 3739.84 3121.28
30 bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090] 1.19288 43509.4 36474.3
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670] High confidence 2.04837 895.633 1834.59
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] Subtracted 5430.7 18263 23693.7
phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326] Low confidence 1780.5 5058.5 3278
31 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151] High confidence Divided 2.04827 895.697 1834.63
melanoma antigen, family b, 6. [refseq;acc:nm_173523] Subtracted 5430.7 18263 23693.7
n33 protein. [swissprot;acc:q13454] Low confidence 1780.5 5058.5 3278
vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274] Divided 1.19287 43503.3 36469.3
32 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] High confidence 2.04793 895.893 1834.73
implantation-associated protein. [refseq;acc:nm_032121] Low confidence Subtracted 1780.5 5058.5 3278
melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] High confidence 5430.7 18263 23693.7
nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] Low confidence Divided 1.19275 43368.8 36360.3
33 guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152] High confidence 2.04611 896.972 1835.3
melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] Subtracted 5430.7 18263 23693.7
septin 6. [swissprot;acc:q14141] Low confidence 1767.9 14773.7 13005.8
vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682] Divided 1.19275 43368.8 36360.3
34 cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847] Subtracted 1758.96 7251 5492.04
guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992] High confidence Divided 2.02382 907.546 1836.71
melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] Subtracted 5430.7 18263 23693.7
protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8] Low confidence Divided 1.1897 6352.4 5339.5
35 deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233] 1.18866 39358.1 33111.4
guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148] High confidence 2.02378 907.564 1836.71
melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] Subtracted 5430.7 18263 23693.7
rhomboid-related protein 4 (ec 3.4.21.-) (ventrhoid transmembrane protein). [swissprot;acc:p58872] Low confidence 1736.6 21503.3 23239.9
36 bax inhibitor-1 (bi-1) (testis enhanced gene transcript). [swissprot;acc:p55061]
guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086] High confidence Divided 2.02344 907.741 1836.76
melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365] Subtracted 5430.7 18263 23693.7
proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100] Low confidence Divided 1.17513 7593.77 6462.09
37 guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488] High confidence 2.02339 907.763 1836.76
jun dimerization protein. [refseq;acc:nm_130469] Low confidence 1.17513 7593.77 6462.09
melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355] High confidence Subtracted 5430.7 18263 23693.7
rhomboid-related protein 1 (ec 3.4.21.-) (rrp) (rhomboid-like protein 1). [swissprot;acc:o75783] Low confidence 1736.6 21503.3 23239.9
38 cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326] 1709.5 11486.4 13195.9
guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087] High confidence Divided 2.02337 907.774 1836.76

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/