Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Value Type Gene Interaction Map Rank Filtered Network Comparison Type description green red network_comparison
Results: HTML CSV LaTeX Showing element 101 to 150 of 29840 in total
Value Type  : Measured
Interaction Map  : High confidence
Rank
Filtered
Network Comparison Type
description
green
red
network_comparison
26 0 Divided fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402] 662 153 4.3268
Subtracted ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464] 2063 2965.5 902.5
1 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6] 892.67 1833.01 2.0534
Subtracted hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] 18263 23693.7 5430.7
27 0 Divided phenylethanolamine n-methyltransferase (ec 2.1.1.28) (pnmtase) (noradrenaline n-methyltransferase). [swissprot;acc:p11086] 139 570 4.10072
Subtracted baculoviral iap repeat-containing protein 5 (apoptosis inhibitor survivin) (apoptosis inhibitor 4). [swissprot;acc:o15392] 13463.1 14357.1 894
1 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150] 895.134 1834.33 2.04922
Subtracted melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 18263 23693.7 5430.7
28 0 Divided beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938] 139 570 4.10072
Subtracted spectrin beta chain, brain 4 (spectrin, non-erythroid beta chain 4) (beta-v spectrin) (bspecv). [swissprot;acc:q9nrc6] 4543.75 5418.2 874.45
1 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798] 895.194 1834.36 2.04912
Subtracted necdin. [swissprot;acc:q99608] 18263 23693.7 5430.7
29 0 Divided potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281] 434.911 111.278 3.90833
Subtracted regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754] 2399.76 3248.95 849.19
1 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08] 895.507 1834.52 2.04858
Subtracted melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 18263 23693.7 5430.7
30 0 Divided dystrophin. [swissprot;acc:p11532] 111.739 427.217 3.82335
Subtracted cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570] 4102.97 3265.25 837.72
1 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670] 895.633 1834.59 2.04837
Subtracted melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 18263 23693.7 5430.7
31 0 Divided dok-like protein. [refseq;acc:nm_024872] 0.00001 35 3500000
Subtracted spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813] 2637 1833 804
1 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151] 895.697 1834.63 2.04827
Subtracted melanoma antigen, family b, 6. [refseq;acc:nm_173523] 18263 23693.7 5430.7
32 0 Divided cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336] 184 598 3.25
Subtracted mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849] 58 859 801
1 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] 895.893 1834.73 2.04793
Subtracted melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] 18263 23693.7 5430.7
33 0 Divided lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893] 39.8063 12.6208 3.15402
Subtracted protein cgi-147. [swissprot;acc:q9y3e5] 9192.38 8396.12 796.26
1 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152] 896.972 1835.3 2.04611
Subtracted melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] 18263 23693.7 5430.7
34 0 Divided glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926] 47 143 3.04255
Subtracted acrc protein; putative nuclear protein. [refseq;acc:nm_052957] 3340.03 4131.06 791.03
1 Divided guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992] 907.546 1836.71 2.02382
Subtracted melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] 18263 23693.7 5430.7
35 0 Divided adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236] 1377 459.5 2.99674
Subtracted filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333] 898 1603 705
1 Divided guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148] 907.564 1836.71 2.02378
Subtracted melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] 18263 23693.7 5430.7
36 0 Divided heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174] 56 157 2.80357
Subtracted oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977] 925.298 1586.07 660.772
1 Divided guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086] 907.741 1836.76 2.02344
Subtracted melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365] 18263 23693.7 5430.7
37 0 Divided 1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446] 934.348 334.401 2.79409
Subtracted wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6] 4550.64 5202.89 652.25
1 Divided guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488] 907.763 1836.76 2.02339
Subtracted melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355] 18263 23693.7 5430.7
38 0 Divided zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623] 120.429 320.012 2.65727
Subtracted clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675] 6127.24 5497.01 630.23

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/