Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 532 to 581 of 12912 in total
Network Comparison Type	Divided
Interaction Map High confidence
Filtered 1
Rank description Value Type red green network_comparison 133 tob1 protein (transducer of erbb-2 1). [source:swissprot;acc:p50616] Ranked 350 290 1.2069 134 dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [source:refseq;acc:nm_032552] Ranked 350 290 1.2069 134 dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [source:swissprot;acc:q9nr33] Rooted 44.849 54.7964 1.2218 134 gaba-a receptor-associated protein. [source:sptrembl;acc:q9by60] Measured 21785.2 16426.1 1.32626 134 p66 alpha. [source:refseq;acc:nm_017660] Squared 81888.8 56306.5 1.45434 135 20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [source:swissprot;acc:p52298] Rooted 54.935 66.6101 1.21253 135 apg3p; pc3-96 protein. [source:refseq;acc:nm_022488] Measured 21785.2 16426.1 1.32626 135 cytoplasmic polyadenylation element binding protein 4. [source:refseq;acc:nm_030627] Ranked 350 290 1.2069 135 transcription repressor p66 beta component of the mecp1 complex. [source:refseq;acc:nm_020699] Squared 81888.8 56306.5 1.45434 136 adiponectin receptor 2. [source:refseq;acc:nm_024551] Rooted 41.8357 50.6469 1.21061 136 cytoplasmic polyadenylation element binding protein 3. [source:refseq;acc:nm_014912] Ranked 350 290 1.2069 136 nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [source:swissprot;acc:q13952] Measured 3620.77 4763.34 1.31556 136 tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [source:swissprot;acc:p17735] Squared 81888.8 56306.5 1.45434 137 ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [source:swissprot;acc:p23511] Measured 3620.77 4763.34 1.31556 137 cell division protein kinase 3 (ec 2.7.1.-). [source:swissprot;acc:q00526] Squared 81606.8 56215.8 1.45167 137 musashi 2 isoform a. [source:refseq;acc:nm_138962] Rooted 54.9787 66.2416 1.20486 137 ras gtpase-activating protein ngap (ras protein activator like 1). [source:swissprot;acc:q9ujf2] Ranked 350 290 1.2069 138 kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [source:refseq;acc:nm_014592] Measured 2755.15 2094.3 1.31555 138 musashi 1. [source:refseq;acc:nm_002442] Rooted 54.9787 66.2416 1.20486 138 putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [source:refseq;acc:nm_016172] Squared 468498 322755 1.45156 138 serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [source:swissprot;acc:p05323] Ranked 194.372 234.204 1.20493 139 amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [source:swissprot;acc:q02410] Ranked 271.752 225.68 1.20415 139 g2/mitotic-specific cyclin b2. [source:swissprot;acc:o95067] Squared 81592.1 56211.1 1.45153 139 nuclear protein ukp68. [source:refseq;acc:nm_024824] Rooted 54.9787 66.2416 1.20486 139 potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [source:refseq;acc:nm_147183] Measured 2759.61 2099.49 1.31442 140 cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [source:swissprot;acc:p24941] Squared 81527.6 56190.6 1.45091 140 filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [source:refseq;acc:nm_001457] Rooted 55.6161 66.7332 1.19989 140 kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [source:refseq;acc:nm_173193] Measured 2760.28 2100.27 1.31425 140 ras-related gtp binding a; ras-related gtp-binding protein. [source:refseq;acc:nm_006570] Ranked 59 49 1.20408 141 g2/mitotic-specific cyclin b1. [source:swissprot;acc:p14635] Squared 81520.8 56188.5 1.45084 141 ras-related gtp binding c; rag c protein. [source:refseq;acc:nm_022157] Ranked 59 49 1.20408 141 rev1-like; rev1 protein; rev1 (yeast homolog)- like. [source:refseq;acc:nm_016316] Rooted 55.6161 66.7332 1.19989 141 small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [source:swissprot;acc:p43330] Measured 4405.4 5782.08 1.3125 142 cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [source:swissprot;acc:p06493] Squared 81478.9 56175.2 1.45044 142 metalloprotease 1; metalloprotease 1 (pitrilysin family). [source:refseq;acc:nm_014889] Measured 9276.47 7090.37 1.30832 142 protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [source:swissprot;acc:q99873] Rooted 55.6161 66.7332 1.19989 142 ras-related gtp binding b short isoform; gtp-binding protein ragb. [source:refseq;acc:nm_006064] Ranked 59 49 1.20408 143 anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [source:refseq;acc:nm_018685] Ranked 59 49 1.20408 143 beta-1,4 mannosyltransferase. [source:refseq;acc:nm_019109] Measured 9275.1 7089.65 1.30826 143 protein arginine n-methyltransferase 4 (ec 2.1.1.-). [source:swissprot;acc:q9nr22] Rooted 55.6161 66.7332 1.19989 143 protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [source:refseq;acc:nm_015316] Squared 124319 86848.2 1.43145 144 kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [source:refseq;acc:nm_014592] Ranked 265.686 319.651 1.20312 144 sad1/unc-84 protein-like 1. [source:swissprot;acc:o94901] Measured 3349.9 4362.61 1.30231 144 tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [source:swissprot;acc:q13625] Squared 123324 86277.9 1.42938 144 u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [source:swissprot;acc:p08621] Rooted 55.6161 66.7332 1.19989 145 filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [source:swissprot;acc:p21333] Rooted 55.6161 66.7332 1.19989 145 nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [source:refseq;acc:nm_006333] Squared 310840 442993 1.42515 145 potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [source:refseq;acc:nm_147183] Ranked 265.639 319.546 1.20293 145 ubiquitin activating enzyme e1-like protein. [source:refseq;acc:nm_006395] Measured 16771.5 12889.1 1.30122 146 associated molecule with the sh3 domain of stam (amsh) like protein. [source:refseq;acc:nm_020799] Measured 11068 8508.5 1.30082 Legend: - Rank is the rank after comparing the two networks - Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions. - Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them - Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions. - Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/