MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 801 to 850 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
401	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	Divided	5201.41	4479.76	1.16109
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Subtracted	1835.3	896.972	938.328
402	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]		6230.94	7168.2	937.26
	leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]	Divided	5201.41	4479.76	1.16109
403	fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]
	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	Subtracted	6259.3	7190.91	931.61
404	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]		7802.31	8731.82	929.51
	leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71]	Divided	5201.41	4479.76	1.16109
405	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	Subtracted	1836.71	907.546	929.164
	laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047]	Divided	5201.41	4479.76	1.16109
406	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	Subtracted	1836.71	907.564	929.146
	thymic stromal co-transporter. [refseq;acc:nm_033051]	Divided	5201.41	4479.76	1.16109
407	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Subtracted	1836.76	907.741	929.019
	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	Divided	6603.41	7664.65	1.16071
408	dok-like protein. [refseq;acc:nm_024872]		6102.59	7081.46	1.1604
	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	Subtracted	1836.76	907.763	928.997
409	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]	Divided	6102.59	7081.46	1.1604
	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Subtracted	1836.76	907.774	928.986
410	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]		6744.05	5815.13	928.92
	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]	Divided	6102.59	7081.46	1.1604
411	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	Subtracted	1836.8	907.903	928.897
	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]	Divided	6102.59	7081.46	1.1604
412	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	Subtracted	1836.81	907.978	928.832
	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	Divided	3594.31	4169.95	1.16015
413	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	Subtracted	1836.81	907.978	928.832
	vav proto-oncogene. [swissprot;acc:p15498]	Divided	6644.99	7707.8	1.15994
414	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]		6744.05	5815.13	1.15974
	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	Subtracted	5051.16	5975.51	924.35
415	j kappa-recombination signal binding protein (rbp-j kappa). [swissprot;acc:q06330]		7725.1	8647.74	922.64
	vav-3 protein. [swissprot;acc:q9ukw4]	Divided	6647.43	7706.18	1.15927
416	human immunodeficiency virus type i enhancer binding protein 3. [refseq;acc:nm_024503]	Subtracted	7725.1	8647.74	922.64
	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	Divided	4509.54	5223.95	1.15842
417	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]		4522.71	5233.14	1.15708
	zinc finger protein 40 (human immunodeficiency virus type i enhancer- binding protein 1) (hiv-ep1) (major histocompatibility complex binding protein 1) (mbp-1) (positive regulatory domain ii binding factor 1) (prdii-bf1). [swissprot;acc:p15822]	Subtracted	7725.1	8647.74	922.64
418	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]	Divided	5493.1	6350.19	1.15603
	human immunodeficiency virus type i enhancer-binding protein 2 (hiv-ep2). [swissprot;acc:p31629]	Subtracted	7725.1	8647.74	922.64
419	cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]	Divided	5493.1	6350.19	1.15603
	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	Subtracted	5039.63	5961.83	922.2
420	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	Divided	10235.2	11830.8	1.15589
	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	Subtracted	5942.49	6853.15	910.66
421	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]		6739.43	7644.55	905.12
	vav-2 protein. [swissprot;acc:p52735]	Divided	6660.02	7697.78	1.15582
422	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	Subtracted	460	1365	905
	nuclear rna export factor 5 (tap-like protein 1) (tapl-1). [swissprot;acc:q9h1b4]	Divided	5206.9	6010.04	1.15425
423	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	Subtracted	6739.61	7644.58	904.97
	nuclear rna export factor 3 (tap-like protein 3) (tapl-3). [swissprot;acc:q9h4d5]	Divided	5207.03	6010.1	1.15423
424	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	Subtracted	6739.63	7644.59	904.96
	nuclear rna export factor 1 (tip associating protein) (tip-associated protein) (mrna export factor tap). [swissprot;acc:q9ubu9]	Divided	5207.78	6010.45	1.15413
425	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	Subtracted	6739.7	7644.6	904.9
	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]	Divided	3729.02	4301.58	1.15354

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.