Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison

Results: HTML CSV LaTeX

Showing element 793 to 842 of 6456 in total

Value Type	Measured
Interaction Map	High confidence
Filtered	1

Rank	description	Network Comparison Type	red	green	network_comparison	
397	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [source:swissprot;acc:p30670]	Subtracted	1834.59	895.633	938.957	
397	nuclear protein skip (ski-interacting protein) (snw1 protein) (nuclear receptor coactivator ncoa-62). [source:swissprot;acc:q13573]	Divided	5367.04	6233.12	1.16137	
398	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [source:swissprot;acc:p50151]	Subtracted	1834.63	895.697	938.933	
398	xpa-binding protein 2 (hcnp protein) (pp3898). [source:swissprot;acc:q9hcs7]	Divided	5084.26	5904.1	1.16125	
399	neuronal acetylcholine receptor protein, alpha-7 chain precursor. [source:swissprot;acc:p36544]	Divided	5201.41	4479.76	1.16109	
399	u6 snrna-associated sm-like protein lsm2 (small nuclear ribonuclear protein d homolog) (g7b) (snrnp core sm-like protein sm-x5). [source:swissprot;acc:q9y333]	Subtracted	4633.92	5572.85	938.93	
400	adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [source:swissprot;acc:o43306]	Divided	5201.41	4479.76	1.16109	
400	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [source:swissprot;acc:q9y3k8]	Subtracted	1834.73	895.893	938.837	
401	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [source:swissprot;acc:o95622]	Divided	5201.41	4479.76	1.16109	
401	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [source:swissprot;acc:p50152]	Subtracted	1835.3	896.972	938.328	
402	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [source:refseq;acc:nm_021069]	Subtracted	6230.94	7168.2	937.26	
402	leucine-rich repeat-containing protein 15 precursor (hlib). [source:swissprot;acc:q8tf66]	Divided	5201.41	4479.76	1.16109	
403	fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [source:refseq;acc:nm_015322]	Divided	5201.41	4479.76	1.16109	
403	ponsin; sh3-domain protein 5 (ponsin). [source:refseq;acc:nm_015385]	Subtracted	6259.3	7190.91	931.61	
404	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [source:swissprot;acc:p55060]	Subtracted	7802.31	8731.82	929.51	
404	leucine-rich repeat protein lrrc3 precursor. [source:swissprot;acc:q9by71]	Divided	5201.41	4479.76	1.16109	
405	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [source:swissprot;acc:p29992]	Subtracted	1836.71	907.546	929.164	
405	laminin gamma-1 chain precursor (laminin b2 chain). [source:swissprot;acc:p11047]	Divided	5201.41	4479.76	1.16109	
406	guanine nucleotide-binding protein g(q), alpha subunit. [source:swissprot;acc:p50148]	Subtracted	1836.71	907.564	929.146	
406	thymic stromal co-transporter. [source:refseq;acc:nm_033051]	Divided	5201.41	4479.76	1.16109	
407	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [source:swissprot;acc:p19086]	Subtracted	1836.76	907.741	929.019	
407	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [source:swissprot;acc:o43516]	Divided	6603.41	7664.65	1.16071	
408	dok-like protein. [source:refseq;acc:nm_024872]	Divided	6102.59	7081.46	1.1604	
408	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [source:swissprot;acc:p11488]	Subtracted	1836.76	907.763	928.997	
409	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [source:swissprot;acc:o60496]	Divided	6102.59	7081.46	1.1604	
409	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [source:swissprot;acc:p19087]	Subtracted	1836.76	907.774	928.986	
410	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [source:swissprot;acc:q9h1y0]	Subtracted	6744.05	5815.13	928.92	
410	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [source:swissprot;acc:q99704]	Divided	6102.59	7081.46	1.1604	
411	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [source:swissprot;acc:p04899]	Subtracted	1836.8	907.903	928.897	
411	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [source:swissprot;acc:p42685]	Divided	6102.59	7081.46	1.1604	
412	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [source:swissprot;acc:p04898]	Subtracted	1836.81	907.978	928.832	
412	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [source:refseq;acc:nm_032390]	Divided	3594.31	4169.95	1.16015	
413	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [source:swissprot;acc:p08754]	Subtracted	1836.81	907.978	928.832	
413	vav proto-oncogene. [source:swissprot;acc:p15498]	Divided	6644.99	7707.8	1.15994	
414	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [source:swissprot;acc:q9h1y0]	Divided	6744.05	5815.13	1.15974	
414	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [source:refseq;acc:nm_002669]	Subtracted	5051.16	5975.51	924.35	
415	j kappa-recombination signal binding protein (rbp-j kappa). [source:swissprot;acc:q06330]	Subtracted	7725.1	8647.74	922.64	
415	vav-3 protein. [source:swissprot;acc:q9ukw4]	Divided	6647.43	7706.18	1.15927	
416	human immunodeficiency virus type i enhancer binding protein 3. [source:refseq;acc:nm_024503]	Subtracted	7725.1	8647.74	922.64	
416	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [source:swissprot;acc:p41227]	Divided	4509.54	5223.95	1.15842	
417	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [source:swissprot;acc:o95817]	Divided	4522.71	5233.14	1.15708	
417	zinc finger protein 40 (human immunodeficiency virus type i enhancer- binding protein 1) (hiv-ep1) (major histocompatibility complex binding protein 1) (mbp-1) (positive regulatory domain ii binding factor 1) (prdii-bf1). [source:swissprot;acc:p15822]	Subtracted	7725.1	8647.74	922.64	
418	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [source:refseq;acc:nm_005872]	Divided	5493.1	6350.19	1.15603	
418	human immunodeficiency virus type i enhancer-binding protein 2 (hiv-ep2). [source:swissprot;acc:p31629]	Subtracted	7725.1	8647.74	922.64	
419	cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [source:refseq;acc:nm_001253]	Divided	5493.1	6350.19	1.15603	
419	nuclear matrix protein nmp200 related to splicing factor prp19. [source:refseq;acc:nm_014502]	Subtracted	5039.63	5961.83	922.2	
420	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [source:swissprot;acc:p00492]	Divided	10235.2	11830.8	1.15589	
420	pef protein with a long n-terminal hydrophobic domain (peflin). [source:refseq;acc:nm_012392]	Subtracted	5942.49	6853.15	910.66	
421	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [source:swissprot;acc:p31260]	Subtracted	6739.43	7644.55	905.12	
421	vav-2 protein. [source:swissprot;acc:p52735]	Divided	6660.02	7697.78	1.15582	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/