Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 658 to 707 of 3228 in total
Value Type: Ranked
Network Comparison Type: Divided
Interaction Map: High confidence
Filtered: 1
\def\wcA{0.16666666666667\textwidth} \def\wcB{0.16666666666667\textwidth} \def\wcC{0.16666666666667\textwidth} \def\wcD{0.16666666666667\textwidth} \def\wcE{0.16666666666667\textwidth} \begin{longtable}{|c|c|c|c|c|} \hline \parbox{\wcA}{\vspace{3pt}\noindent Rank\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent description\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent red\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent green\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent network\_comparison\vspace{3pt}}\\ \hline \hline \parbox{\wcA}{\vspace{3pt}\noindent 658\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [source:refseq;acc:nm\_032468]\vspace{3pt}}&\multirow{12}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 229.072\vspace{3pt}}}&\multirow{12}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 216.576\vspace{3pt}}}&\multirow{12}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.0577\vspace{3pt}}}\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 659\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [source:swissprot;acc:q9y5j3]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 660\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent actin binding lim protein 2. [source:refseq;acc:nm\_032432]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 661\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent hairy/enhancer-of-split related with yrpw motif-like. [source:refseq;acc:nm\_014571]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 662\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent synapsin ii. [source:swissprot;acc:q92777]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 663\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent mitochondrial ribosome recycling factor. [source:refseq;acc:nm\_138777]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 664\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [source:swissprot;acc:p50542]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 665\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [source:refseq;acc:nm\_012259]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 666\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [source:swissprot;acc:q14469]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 667\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [source:swissprot;acc:q13011]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 668\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [source:refseq;acc:nm\_002313]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 669\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent synapsin i (brain protein 4.1). [source:swissprot;acc:p17600]\vspace{3pt}}&&&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 670\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent autoantigen ngp-1. [source:swissprot;acc:q13823]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 250.302\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 236.817\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05694\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 671\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent nucleotide-binding protein 1 (nbp 1). [source:swissprot;acc:p53384]\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 210.739\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 199.398\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.05688\vspace{3pt}}}\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 672\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent nucleotide binding protein 2 (nbp 2). [source:swissprot;acc:q9y5y2]\vspace{3pt}}&&&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 673\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [source:swissprot;acc:o14936]\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 226.497\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 214.355\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.05664\vspace{3pt}}}\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 674\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent hypoxia-inducible factor-3 alpha isoform a; inhibitory pas domain protein. [source:refseq;acc:nm\_152794]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 675\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent single-minded homolog 1. [source:swissprot;acc:p81133]\vspace{3pt}}&&&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 676\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent dna-directed rna polymerase ii 19 kda polypeptide (ec 2.7.7.6) (rpb7). [source:swissprot;acc:p52433]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 232.469\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 245.613\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05654\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 677\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [source:swissprot;acc:q9y4z0]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 228.944\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 216.745\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05628\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 678\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent sorting nexin 5. [source:swissprot;acc:q9y5x3]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 208.482\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 220.175\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05609\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 679\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent homeobox protein hox-c4 (hox-3e) (cp19). [source:swissprot;acc:p09017]\vspace{3pt}}&\multirow{9}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 132.413\vspace{3pt}}}&\multirow{9}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 125.389\vspace{3pt}}}&\multirow{9}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.05602\vspace{3pt}}}\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 680\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent homeobox protein hox-b4 (hox-2f) (hox-2.6). [source:swissprot;acc:p17483]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 681\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent homeobox protein hox-c5 (hox-3d) (cp11). [source:swissprot;acc:q00444]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 682\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [source:swissprot;acc:p09630]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 683\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [source:swissprot;acc:p09016]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 684\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [source:swissprot;acc:p09067]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 685\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent homeobox protein hox-a5 (hox-1c). [source:swissprot;acc:p20719]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 686\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent homeobox protein hox-a4 (hox-1d) (hox-1.4). [source:swissprot;acc:q00056]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 687\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent retinal short-chain dehydrogenase/reductase 3. [source:refseq;acc:nm\_016246]\vspace{3pt}}&&&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 688\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent dna-directed rna polymerase ii 16 kda polypeptide (ec 2.7.7.6) (rpb4). [source:swissprot;acc:o15514]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 237.554\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 250.823\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05586\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 689\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [source:swissprot;acc:p17987]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 135.379\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 128.225\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05579\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 690\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent nuclear protein skip (ski-interacting protein) (snw1 protein) (nuclear receptor coactivator ncoa-62). [source:swissprot;acc:q13573]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 220.593\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 208.987\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05553\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 691\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [source:refseq;acc:nm\_005872]\vspace{3pt}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 217.602\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 206.195\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.05532\vspace{3pt}}}\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 692\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [source:refseq;acc:nm\_001253]\vspace{3pt}}&&&\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 693\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent rna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen-1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1). [source:swissprot;acc:p51513]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 222.554\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 234.847\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05524\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 694\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [source:swissprot;acc:q07864]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 241.907\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 229.35\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05475\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 695\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent peptidylprolyl isomerase-like 4; cyclophilin-type peptidyl-prolyl cis-trans isomerase; ppiase; serologically defined breast cancer antigen ny-br-18. [source:refseq;acc:nm\_139126]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 226.135\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 214.405\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05471\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 696\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent sr rich protein. [source:refseq;acc:nm\_032870]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 225.293\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 213.64\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05455\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 697\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent ferritin heavy chain (ferritin h subunit). [source:swissprot;acc:p02794]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 220.444\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent 209.113\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent 1.05419\vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 698\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [source:refseq;acc:nm\_177478]\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent 220.437\vspace{3pt}}&\multirow{10}{*}{\parbox{\wcD}{\vspace{3pt}\noindent 209.118\vspace{3pt}}}&\multirow{10}{*}{\parbox{\wcE}{\vspace{3pt}\noindent 1.05413\vspace{3pt}}}\\\cline{1-3} \parbox{\wcA}{\vspace{3pt}\noindent 699\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent cellular repressor of e1a-stimulated genes 2. [source:refseq;acc:nm\_153836]\vspace{3pt}}&\multirow{9}{*}{\parbox{\wcC}{\vspace{3pt}\noindent 220.438\vspace{3pt}}}&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 700\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [source:sptrembl;acc:q9byw6]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 701\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [source:swissprot;acc:o14490]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 702\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent putative adenosylhomocysteinase 2 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [source:swissprot;acc:o43865]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 703\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent limkain b1. [source:refseq;acc:nm\_019081]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 704\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent putative adenosylhomocysteinase 3 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [source:swissprot;acc:q96hn2]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 705\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent cellular repressor of e1a-stimulated genes. [source:refseq;acc:nm\_003851]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 706\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [source:swissprot;acc:o95886]\vspace{3pt}}&&&\\\cline{1-2} \parbox{\wcA}{\vspace{3pt}\noindent 707\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent kininogen precursor (alpha-2-thiol proteinase inhibitor) [contains: bradykinin]. [source:swissprot;acc:p01042]\vspace{3pt}}&&&\\\hline nd{longtable}
Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/