MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 6308 to 6357 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
3154	nucleoporin 50 kda (nuclear pore-associated protein 60 kda-like) (pro1146). [swissprot;acc:q9ukx7]	Subtracted	0	0	0
3155	transforming growth factor beta 2 precursor (tgf-beta 2) (glioblastoma-derived t-cell suppressor factor) (g-tsf) (bsc-1 cell growth inhibitor) (polyergin) (cetermin). [swissprot;acc:p08112]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3156	tektin 2 (tektin-t) (testicular tektin b1-like protein). [swissprot;acc:q9uif3]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3157	vesicle transport-related protein isoform a; vesicle transport-related protein. [refseq;acc:nm_016106]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3158	integrin alpha-6 precursor (vla-6) (cd49f). [swissprot;acc:p23229]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3159	trinucleotide repeat containing 6; edie; gw182 autoantigen. [refseq;acc:nm_014494]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3160	cyclin k. [swissprot;acc:o75909]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3161	brca1 associated protein. [refseq;acc:nm_006768]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3162	phosphatidylethanolamine-binding protein (pebp) (prostatic binding protein) (hcnppp) (neuropolypeptide h3) (raf kinase inhibitor protein) (rkip) [contains: hippocampal cholinergic neurostimulating peptide (hcnp)]. [swissprot;acc:p30086]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3163	ccr4-not transcription complex, subunit 3; not3 (negative regulator of transcription 3, yeast) homolog. [refseq;acc:nm_014516]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3164	transcription factor ap-2 gamma (ap2-gamma) (activating enhancer- binding protein 2 gamma) (transcription factor erf-1). [swissprot;acc:q92754]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3165	gpi transamidase component pig-s (phosphatidylinositol-glycan biosynthesis, class s protein). [swissprot;acc:q96s52]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3166	myotubularin-related protein 2 (ec 3.1.3.-). [swissprot;acc:q13614]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3167	centromere/kinetochore protein zw10 homolog. [swissprot;acc:o43264]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3168	cop-coated vesicle membrane protein p24 precursor (p24a). [swissprot;acc:q15363]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3169	transcriptional repressor nf-x1 (ec 6.3.2.-) (nuclear transcription factor, x box-binding, 1). [swissprot;acc:q12986]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3170	ecotropic virus integration 1 site protein. [swissprot;acc:q03112]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3171	cyclin t2. [swissprot;acc:o60583]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3172	hormone sensitive lipase (ec 3.1.1.-) (hsl). [swissprot;acc:q05469]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3173	phosphoinositide-3-kinase, class 3; vps34; phosphatidylinositol 3-kinase, class 3. [refseq;acc:nm_002647]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3174	transmembrane 9 superfamily protein member 3 precursor (sm-11044 binding protein) (ep70-p-iso). [swissprot;acc:q9hd45]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3175	tubulin alpha-3/alpha-7 chain (alpha-tubulin 3/7). [swissprot;acc:p05214]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3176	phosphate carrier protein, mitochondrial precursor (ptp). [swissprot;acc:q00325]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3177	ergic-53 protein precursor (er-golgi intermediate compartment 53 kda protein) (lectin, mannose-binding 1) (gp58) (intracellular mannose specific lectin mr60). [swissprot;acc:p49257]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3178	transcription initiation factor iie, beta subunit (tfiie-beta). [swissprot;acc:p29084]	Divided	0.00001	0.00001	1
		Subtracted	0	0	0
3179	carcinoma related gene. [refseq;acc:nm_016041]	Divided	0.00001	0.00001	1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.