MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Gene	Rank	red	Network Comparison Type	Value Type	description	Interaction Map	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 601 to 650 of 1923 in total

red  : 0
Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
green  : 0
network_comparison  : 0

Rank	Value Type	description
2898	Ranked	likely ortholog of mouse c-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13; c-type lectin 13; likely ortholog of rat kupffer cell c-type lectin receptor. [refseq;acc:nm_173535]
	Squared
	Rooted
2899	Measured	sparc-like protein 1 precursor (high endothelial venule protein) (hevin) (mast 9). [swissprot;acc:q14515]
	Ranked
	Squared
	Rooted
2900	Measured	schwannomin interacting protein 1. [refseq;acc:nm_014575]
	Ranked
	Squared
	Rooted
2901	Measured	casein kinase i, gamma 3 isoform (ec 2.7.1.-) (cki-gamma 3). [swissprot;acc:q9y6m4]
	Ranked
	Squared
	Rooted
2902	Measured	ubiquitin protein ligase. [refseq;acc:nm_130466]
	Ranked
	Squared
	Rooted
2903	Measured	protein transport protein sec24d (sec24-related protein d). [swissprot;acc:o94855]
	Ranked
	Squared
	Rooted
2904	Measured	6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [swissprot;acc:q03393]
	Ranked
	Squared
	Rooted
2905	Measured	integrin beta-1 precursor (fibronectin receptor beta subunit) (cd29 antigen) (integrin vla-4 beta subunit). [swissprot;acc:p05556]
	Ranked
	Squared
	Rooted
2906	Measured	thousand and one amino acid protein kinase. [refseq;acc:nm_004783]
	Ranked
	Squared
	Rooted
2907	Measured	fructose-bisphosphate aldolase a (ec 4.1.2.13) (muscle-type aldolase) (lung cancer antigen ny-lu-1). [swissprot;acc:p04075]
	Ranked
	Squared
	Rooted
2908	Measured	serine/threonine-protein kinase chk1 (ec 2.7.1.-). [swissprot;acc:o14757]
	Ranked
	Squared
	Rooted
2909	Measured	nk6 transcription factor related, locus 2; nk homeobox family 6, b; glial and testis-specific homeobox protein; homeobox 6b. [refseq;acc:nm_177400]
	Ranked
	Squared
	Rooted
2910	Measured	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]
	Ranked
	Squared

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.