MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Gene	description	Rank	Value Type	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 551 to 600 of 6456 in total

Value Type  : Measured
Filtered  : 1
Interaction Map  : High confidence

description	Rank	Network Comparison Type	red	green	network_comparison
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	2646	Subtracted	8936.97	8999.55	62.58
	2665	Divided			1.007
anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	1612	Subtracted	6079.19	6503.12	423.93
	1647	Divided			1.06973
anaphase-promoting complex subunit 2; anaphase-promoting complex 2. [refseq;acc:nm_013366]	657	Subtracted	10341.2	9630.35	710.85
	1518	Divided			1.07381
androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	1969		4374.32	4126.96	1.05994
	2292	Subtracted			247.36
angiomotin like 2; leman coiled-coil protein; angiomotin-like protein 2. [refseq;acc:nm_016201]	1764		5829.61	6218.27	388.66
	1771	Divided			1.06667
angiomotin. [refseq;acc:nm_133265]	1763	Subtracted			388.66
	1770	Divided			1.06667
anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	59	Subtracted	20911	24908.5	3997.5
	322	Divided			1.19117
ankyrin 2 (brain ankyrin) (ankyrin b) (ankyrin, nonerythroid). [swissprot;acc:q01484]	1529	Subtracted	5916.05	6350.53	434.48
	1533	Divided			1.07344
ankyrin 3 (ank-3) (ankyrin g). [swissprot;acc:q12955]	1528	Subtracted			434.48
	1532	Divided			1.07344
ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	2707	Subtracted	5603.24	5583.64	19.6
	2713	Divided			1.00351
annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	963	Subtracted	5778.65	6328.56	549.91
	995	Divided			1.09516
annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	977	Subtracted	5780.34	6329.3	548.96
	1005	Divided			1.09497
antithrombin-iii precursor (atiii) (pro0309). [swissprot;acc:p01008]	1692		5767.69	6165.87	1.06904
	1718	Subtracted			398.18
apg3p; pc3-96 protein. [refseq;acc:nm_022488]	43		21785.2	16426.1	5359.1
	135	Divided			1.32626
apical-like protein (apxl protein). [swissprot;acc:q13796]	595	Subtracted	6088.77	6834.87	746.1
	658	Divided			1.12254
apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	183		4069.83	5252.17	1.29051
	287	Subtracted			1182.34
apolipoprotein a-i binding protein; apoa-i binding protein. [refseq;acc:nm_144772]	586		6139.04	6893.7	754.66
	656	Divided			1.12293
apolipoprotein b-100 precursor (apo b-100) [contains: apolipoprotein b-48 (apo b-48)]. [swissprot;acc:p04114]	1644		5782.92	6186.39	1.06977
	1681	Subtracted			403.47
apopain precursor (ec 3.4.22.-) (cysteine protease cpp32) (yama protein) (cpp-32) (caspase-3) (casp-3) (srebp cleavage activity 1) (sca-1). [swissprot;acc:p42574]	949	Divided	4633.48	5084.24	1.09728
	1416	Subtracted			450.76
apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]	853	Divided	4078.45	4502.32	1.10393
	1616	Subtracted			423.87
apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	716		5874.74	6533.34	658.6
	771	Divided			1.11211
apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	2522	Subtracted	7181.3	7057.99	123.31
	2589	Divided			1.01747
apoptosis-inducing factor (aif)-homologous mitochondrion-associated inducer of death; p53-responsive gene 3. [refseq;acc:nm_032797]	1455	Subtracted	5945.56	6389.63	444.07
	1496	Divided			1.07469
apurinic/apyrimidinic endonuclease 2; apurinic/apyrimidinic endonuclease-like 2; apex nuclease-like 2. [refseq;acc:nm_014481]	1225		5546.5	6019.57	1.08529
	1318	Subtracted			473.07
aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]	196		10640.2	12117.8	1477.6
	523	Divided			1.13887

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.