MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Gene	description	Rank	Value Type	Network Comparison Type	Filtered	Interaction Map	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 501 to 550 of 7460 in total

Value Type  : Measured
Interaction Map  : High confidence

description	Rank	Network Comparison Type	Filtered	red	network_comparison	green
adenosine kinase (ec 2.7.1.20) (ak) (adenosine 5'-phosphotransferase). [swissprot;acc:p55263]	1372	Subtracted	1	6376.12	457.47	6833.59
	1581	Divided			1.07175
adenosylhomocysteinase (ec 3.3.1.1) (s-adenosyl-l-homocysteine hydrolase) (adohcyase). [swissprot;acc:p23526]	940			5568.96	1.09775	6113.35
	984	Subtracted			544.39
adenovirus 5 e1a-binding protein (bs69 protein). [swissprot;acc:q15326]	1745			6156.28	392.75	6549.03
	1851	Divided			1.0638
adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	401			5201.41	1.16109	4479.76
	631	Subtracted			721.65
adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]	400	Divided			1.16109
	630	Subtracted			721.65
adenylate kinase isoenzyme 2, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p54819]	2385	Divided		3716.43	1.04111	3569.68
	2505	Subtracted			146.75
adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144]	274		0	1491.75	99.85	1591.6
	347	Divided			1.06693
	2228		1	3650.82	1.04759	3484.97
	2447	Subtracted			165.85
adenylosuccinate lyase (ec 4.3.2.2) (adenylosuccinase) (asl) (asase). [swissprot;acc:p30566]	1084			7444.28	519.72	7964
	1640	Divided			1.06981
adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]	458	Subtracted	0	1318.37	7.7	1310.67
	479	Divided			1.00587
	551	Subtracted	1	6503.1	779.84	7282.94
	679	Divided			1.11992
adenylosuccinate synthetase (ec 6.3.4.4) (imp--aspartate ligase) (adss) (ampsase). [swissprot;acc:p30520]	552	Subtracted		6503.03	779.47	7282.5
	680	Divided			1.11986
adenylyl cyclase-associated protein 1 (cap 1). [swissprot;acc:q01518]	1492	Subtracted		5989.3	437.87	6427.17
	1541	Divided			1.07311
adenylyl cyclase-associated protein 2 (cap 2). [swissprot;acc:p40123]	262		0	764.479	1.12926	676.971
	293	Subtracted			87.508
	1536		1	5984.88	434.23	6419.11
	1562	Divided			1.07255
adhesion regulating molecule 1 precursor (110 kda cell membrane glycoprotein) (gp110). [swissprot;acc:q16186]	1863	Subtracted		5826	369.48	6195.48
	1884	Divided			1.06342
adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	2715	Subtracted		5603.24	19.6	5583.64
	2723	Divided			1.00351
adiponectin receptor 2. [refseq;acc:nm_024551]	317			3153.1	1.19329	3762.56
	811	Subtracted			609.46
adp,atp carrier protein, fibroblast isoform (adp/atp translocase 2) (adenine nucleotide translocator 2) (ant 2). [swissprot;acc:p05141]	1119	Divided		5322.16	1.08948	5798.38
	1285	Subtracted			476.22
adp,atp carrier protein, heart/skeletal muscle isoform t1 (adp/atp translocase 1) (adenine nucleotide translocator 1) (ant 1). [swissprot;acc:p12235]	1118	Divided			1.08948
	1283	Subtracted			476.22
adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	25		0	459.5	917.5	1377
	35	Divided			2.99674
	1117		1	5322.16	1.08948	5798.38
	1282	Subtracted			476.22
adp-ribosylation factor 1. [swissprot;acc:p32889]	1824	Divided		5633.44	1.06454	5997
	1892	Subtracted			363.56
adp-ribosylation factor 3. [swissprot;acc:p16587]	92	Divided	0	300.697	1.56086	469.346
	190	Subtracted			168.649
	1826	Divided	1	5633.44	1.06454	5997
	1894	Subtracted			363.56

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.