MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Value Type	description	Interaction Map	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 151 to 200 of 12912 in total

Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
38	Squared	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	106226	192141	1.80879
	Rooted	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	40.2804	24.3692	1.65292
39	Measured	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	1836.8	907.903	2.02312
	Ranked	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	322	253	1.27273
	Squared	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	106226	192141	1.80879
	Rooted	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	40.28	24.37	1.65285
40	Measured	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	1836.81	907.978	2.02297
	Ranked	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	322	253	1.27273
	Squared	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	144940	81169.7	1.78564
	Rooted	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	40.2797	24.3705	1.65281
41	Measured	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	1836.81	907.978	2.02297
	Ranked	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	322	253	1.27273
	Squared	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	144912	81155	1.78562
	Rooted	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	40.2797	24.3705	1.65281
42	Measured	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	1857.32	958.237	1.93827
	Ranked	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	204.641	160.957	1.2714
	Squared	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	144911	81154.7	1.78561
	Rooted	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	40.225	24.7051	1.62821
43	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	1881.02	1027.36	1.83093
	Ranked	jun dimerization protein. [refseq;acc:nm_130469]	204.641	160.957	1.2714
	Squared	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	144876	81136.5	1.78558
	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	40.6302	25.4452	1.59677
44	Measured		1931.34	1057.39	1.82652
	Ranked	fos-related antigen 2. [swissprot;acc:p15408]	204.641	161.046	1.2707
	Squared	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	139741	78454.6	1.78117
	Rooted	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	40.5691	25.4263	1.59556
45	Measured		1926.69	1056.02	1.82448
	Ranked	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	204.641	161.051	1.27066
	Squared	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	129597	73157.5	1.77148
	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	40.081	25.1546	1.59339
46	Measured	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	779.167	1390.33	1.78438
	Ranked	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	204.642	161.068	1.27053
	Squared	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	129597	73157.5	1.77148
	Rooted	deltex 2. [refseq;acc:nm_020892]	27.634	43.9629	1.5909
47	Measured	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	779.167	1390.33	1.78438
	Ranked	gbp protein isoform a. [refseq;acc:nm_017870]	325.586	256.492	1.26938
	Squared	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	98517.9	56927.2	1.73059
	Rooted	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	27.7078	44.017	1.58861
48	Measured	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	779.167	1390.33	1.78438
	Ranked	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	65.4586	83.0461	1.26868
	Squared	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	6300.2	10703.5	1.69891
	Rooted	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	27.7254	44.0299	1.58807
49	Measured	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	779.167	1390.33	1.78438
	Ranked	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	133	105	1.26667
	Squared	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	28994.2	17134.8	1.69212
	Rooted	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	27.7254	44.0299	1.58807
50	Measured	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	779.167	1390.33	1.78438
	Ranked	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	133	105	1.26667
	Squared	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	28994.2	17134.8	1.69212
	Rooted	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	27.7254	44.0299	1.58807

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.